Uterine Myomas and Treatments

Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids

This study identifies distinct senescent cell populations in human fibroids and shows their role in ECM remodeling and vascular dysfunction through single-cell RNA sequencing and functional analysis.

Spatially Mapping the Mechanical and Structural Properties of the Seedling Uterine Fibroid-Myometrium Interface

This study maps the mechanical, structural, and compositional properties of seedling uterine fibroids at the fibroid-myometrium interface, revealing distinct differences compared to surrounding tissue.

Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids

This study shows that vitamin D3 reduces R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids, leading to growth inhibition in xenograft models.

A phosphorylation switch in PAGE4 drives MED12-mutant fibroid pathogenesis

The paper identifies a phosphorylation switch in PAGE4 as a key mechanism in MED12-mutant fibroid pathogenesis, revealing its role in rewiring the interactome and transcriptional machinery.

Regulatory Role for Tumor Suppressor REST on Estrogen Receptor (ESR1) Expression and Leiomyoma Pathophysiology

This study identifies REST as a regulator of ESR1 expression and highlights its role in leiomyoma pathophysiology through epigenetic mechanisms.

Long-Term Organ Culture Reveals Differential Stem Cell-Driven Remodelling in Myometrium and MED12-Mutant Uterine Leiomyoma

This study uses long-term organ culture to compare stem cell dynamics in myometrium and MED12-mutant uterine leiomyoma, revealing distinct gene expression and pathway differences.

A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

The paper integrates multi-omics data from uterine fibroids, myometrium, and endometrium to identify differential splicing and molecular pathways associated with abnormal uterine bleeding.

Blood pressure, cardiometabolic traits and cardiovascular events in women with uterine fibroids: a genetic correlation and Mendelian randomization study

This study investigates genetic correlations and causal relationships between uterine fibroids and cardiometabolic traits using genetic data and Mendelian randomization.

Loss of PRICKLE1 in the myometrium leads to reduced fertility, abnormal myometrial architecture, and aberrant extracellular matrix deposition in mice.

This study shows that loss of Prickle1 in mouse myometrium causes uterine leiomyoma-like features, including altered collagen, ECM deposition, and Wnt/PCP signaling disruption.

Estrogen receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis

This study identifies a mechanism by which estrogen receptor alpha suppresses PRICKLE1, leading to REST loss and promoting uterine fibroid development.

Upregulation of DEK Expression in Uterine Myomas and Cervical Cancer as a Potential Prognostic Factor

This study examines DEK protein and mRNA expression in uterine myomas and cervical cancer tissues, finding higher DEK levels in cervical cancer and suggesting its potential as a prognostic biomarker.

Unraveling the Molecular Landscape of Uterine Fibroids, Insights into HMGA2 and Stem Cell Involvement

This study investigates HMGA2 overexpression in myometrial cells, showing it induces a stem cell-like state and contributes to fibroid development through dedifferentiation and altered extracellular matrix pathways.

Cysteine-Rich Intestinal Protein 1 is a Novel Surface Marker for Myometrial Stem/Progenitor Cells.

The paper identifies CRIP1 as a novel surface marker for myometrial stem/progenitor cells using bulk and single-cell RNA-seq analyses.

Patient-derived xenograft studies of fumarate hydratase (FH) -deficient uterine leiomyoma subtype.

This study investigates the growth of FH-deficient uterine leiomyoma using patient-derived xenografts, finding that E2 and P4 drive growth via SMTC proliferation and hypertrophy, with E2 sensitizing to P4.

Exploring potential causal genes for uterine leiomyomas: A summary data-based Mendelian randomization and FUMA analysis

The paper uses Mendelian randomization and FUMA to identify genetic variants and genes potentially involved in uterine leiomyoma pathogenesis using GWAS summary data.

Evidence of a causal relationship between genetic tendency to gain muscle mass and uterine leiomyomata

This study identifies 36 novel genetic loci associated with uterine leiomyomata and suggests a causal link between genetic predisposition to increased fat-free mass and UL risk.

Single Cell atlas of uterine myometrium and leiomyomas reveals diverse and novel cell types of non-monoclonal origin.

The paper uses single-cell RNA sequencing to analyze uterine myometrium and leiomyomas, revealing novel cell types and non-monoclonal origins of leiomyomas.

MiR-17-5p regulates proliferation and apoptosis of uterine fibroids via targeting ESR1

This study investigates the role of ESR1 and miR-17 in regulating proliferation and apoptosis of uterine fibroid cells and their interaction.

Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis

ESR1, WT1, WNT4, ATM and TERT loci are major contributors to uterine leiomyoma predisposition

This study identifies five new genetic loci associated with uterine leiomyoma risk and links them to estrogen receptor alpha and genetic stability.