Antimicrobial Peptides and Activities

Helix Design Studio: designing antimicrobial peptide candidates for membrane environments

Helix Design Studio designs antimicrobial peptides by optimizing sequence compatibility with target membrane environments while balancing interactions across different conditions.

Branching Suppresses Self-Aggregation while Preserving Membrane Association in SET-M33: An Atomistic Molecular Dynamics Study

This study uses molecular dynamics simulations to show that branching in SET-M33 reduces self-aggregation while maintaining membrane association compared to its linear counterpart Q33.

STRUCTURAL AND MOLECULAR DYNAMICS ANALYSIS OF HUMAN β-DEFENSIN 1 VARIANTS REVEALS DISTINCT PERTURBATION SIGNATURES

This study analyzes molecular dynamics of hBD-1 variants to identify perturbation signatures and prioritize variants for structure-function testing.

A diverse family of protein antibiotics inhibits the BAM complex by β-signal mimicry

This study identifies how diverse Llps inhibit the BAM complex by β-signal mimicry, revealing structural and functional mechanisms across Pseudomonas species.

Novel Synthetic Polymyxin Variants Inspired by Newly Uncovered Natural Sequences Explored as Potential Antibiotics

The paper screens environmental bacteria to discover new polymyxin variants, which show varied antibacterial activity compared to colistin.

LL-37 and Citrullinated-LL-37 elicited Transcriptome and Cytokine Profiles in Human Bronchial Epithelial Cells: Citrullination dampens the inflammatory biosignature

This study compares the transcriptome and cytokine profiles of human bronchial epithelial cells stimulated with LL-37 and its citrullinated form, finding that citrullination reduces the inflammatory response.

Silicon exaptation discovers antimicrobial peptides

The paper uses machine learning to discover antimicrobial peptides through an unintended functional property revealed by the algorithm.

Distinctive Lacritin Cleavage-Potentiated Bactericidal Alteration of the P. aeruginosa Transcriptome

This study identifies N-104, a cleavage-potentiated form of lacritin, as a bactericidal agent that alters the transcriptome of P. aeruginosa PA14, reducing virulence, fitness, metabolism, and stress response while increasing efflux and anaerobic respiration.

Mimicin, an antimicrobial protein encoded by mimivirus

The paper identifies Mimicin, an antimicrobial protein from mimiviruses, showing broad in vitro activity against bacteria, yeast, and phages but not other viruses or human cells.

Cardiolipin regulates free energy of folding and vesicle leakage of CM15 antimicrobial peptides in bacterial inner membranes

This study investigates how cardiolipin affects the folding and membrane disruption of the antimicrobial peptide CM15 using simulations and experiments.

Coarse composition suffices: tabular in-context learning for multi-activity antimicrobial peptide profiling

The paper shows a sequence-only pipeline using TabPFN achieves high accuracy in multi-activity antimicrobial peptide profiling, outperforming complex deep models.

Designing antimicrobials with programmable mechanism and safety

OmegAMP generates antimicrobial peptides with controlled physicochemical properties and safety profiles, showing activity against drug-resistant bacteria in vitro and in vivo.

Assessing the translation of AI-prioritized genome-derived peptide fragments into validated antimicrobial candidates

This study evaluates AI-prioritized antimicrobial peptides derived from Malassezia furfur genomes, showing their antimicrobial activity and highlighting AI prediction biases.

Lipoproteins modulate the uptake and biological functionof cationic cell-penetrating peptides across the animal lineage.

This study identifies lipoprotein-mediated endocytosis as a conserved mechanism for cationic cell-penetrating peptides across animal lineages, showing it modulates their antimicrobial function.

Proteome-Scale Mining and Multi-Objective Prioritization of Encrypted Antimicrobial Peptides with Experimental Validation

The paper develops a framework to mine and prioritize encrypted antimicrobial peptides from bacterial genomes, validates three candidates experimentally, and shows concentration-dependent activity against E. coli and S. aureus.

Genome-context-aware discovery of antibacterial peptides from bacterial small open reading frames

The paper identifies antibacterial peptides from bacterial sORFs by combining sequence analysis with genomic context, finding that genomic evidence is crucial for reliable candidates.

A PLUM Job: Peptide modeLs for Understanding and engineering antiMicrobial therapeutics

PLUM generates antimicrobial peptides with controlled function and length, achieving high yields and diverse sequences with favorable predicted properties.

Ancient human mitochondrial genomes encode antimicrobial peptides

The paper identifies antimicrobial peptides encoded in ancient human mitochondrial genomes and validates their activity against bacteria.

SAMP V2: A novel stacking ensemble learning model for antimicrobial peptides identification based on augmented split amino acid composition with biochemical-sequence-order information

SAMP V2 improves antimicrobial peptide identification by integrating biochemical and sequence-order information into split amino acid composition, outperforming existing models on multiple datasets.

Impact of cathelicidin cleavage by SpeB on Streptococcus pyogenes CovRS signaling

This study shows that SpeB cleavage of LL-37 does not impair CovRS signaling or reduce Spy's resistance to LL-37.

Chimerophore antibiotics: engineered multimodal host defense peptides

The paper designs chimerophore antibiotics by fusing non-lytic HDPs to create multimodal peptides with broad-spectrum activity and serum tolerance.

Bacteroidales Secreted Antimicrobial Protein-1 receptor recognition is coupled to protease-activation to form bactericidal pores.

This study defines the mechanism of BSAP-1 toxin action, showing receptor recognition and protease-activation lead to pore formation in target cells.

Structural and Functional Plasticity of the Staphylococcus aureus Virulence-Associated Amyloid Peptide PSMα1

This paper investigates how environmental conditions influence the structural assembly and cytotoxic function of the Staphylococcus aureus virulence peptide PSM1, revealing condition-dependent polymorphic structures and their role in host-cell interactions.

Evolutionary Design of Membrane-Lytic Antimicrobial Peptides with Mixture of Experts

This paper introduces AMPainterV2, a model that designs membrane-lytic antimicrobial peptides using generative adversarial imitation learning, achieving active peptides with improved activity and miniaturization.

Computational evolutionary approach to generate antimicrobial peptides

This study uses deep learning and evolutionary methods to design antimicrobial peptides with selective activity against specific bacteria.

Structural Tuning of HEWL Amyloid Polymorphs Enhances Antibacterial Activity Against Gram-Positive and Gram-Negative Pathogens

This study shows that structurally distinct amyloid polymorphs of HEWL have enhanced antibacterial activity compared to native HEWL, with flexible fibrils showing the strongest activity against multiple bacterial strains.

Cross-Resistance Limits the Ability of Antimicrobial Peptide Combinations to Delay Resistance Evolution

This study shows that cross-resistance, not mode of action, determines the effectiveness of antimicrobial peptide combinations in delaying resistance evolution.

Extracellular injection system combined with peptides for intracellular Staphylococcus aureus treatment

This paper develops a platform using extracellular injection systems to deliver antimicrobial peptides intracellularly for treating Staphylococcus aureus infections, showing effective bacterial inhibition and wound healing in mice.

Human alpha-defensin 5 stabilizes the enterovirus A71 capsid and blocks infection

This paper shows human alpha-defensin 5 inhibits enterovirus A71 by stabilizing its capsid and blocking genome release during infection.

Pathogen context reshapes antimicrobial peptide generation

This paper introduces AMPHORA, a pathogen-conditioned generator of antimicrobial peptides, showing that incorporating pathogen-specific features improves peptide design and potency.