Prenatal Substance Exposure Effects

Prenatal Alcohol Exposure Downregulates Focal Adhesion Molecules Tensin 1 and Tensin 2 Contributing to Cerebrovascular Dysfunction

This study shows prenatal alcohol exposure reduces Tns1 and Tns2 in brain microvascular endothelial cells, impairing angiogenesis, and that miR-150-5p mediates this effect.

Automated pup-level analysis reveals distinct effects of prenatal CBD and THC exposure on maternal retrieval

This study uses automated analysis to show that prenatal CBD and THC exposure leads to distinct effects on maternal retrieval behavior in mice, with compound-specific changes in kinematics and learning.

Prenatal alcohol and cannabinoid co-exposure increases ethanol-seeking in adult offspring and produces sex-dependent medial prefrontal cannabinoid receptor 1 expression.

This study shows that prenatal exposure to both alcohol and cannabinoids increases ethanol-seeking behavior in adult male offspring and alters cannabinoid receptor expression in the medial prefrontal cortex.

Transcriptomic Analysis of the Newborn Mammary Gland Identifies Prenatal Ethanol-Induced Remodeling of Insulin Signaling and Enhanced Proliferative Programming

This study identifies prenatal ethanol-induced molecular reprogramming in newborn mammary glands, including altered insulin signaling and enhanced proliferative programming.

Prenatal fentanyl and Δ9-tetrahydrocannabinol exposure disrupt placental function and fetal growth in a mouse model of multidrug use

This study shows that prenatal exposure to fentanyl and THC in mice impairs placental function and causes fetal growth restriction, with the greatest effects seen when both drugs are used together.

Learning and Memory Performance in a Rat Model of Perigestational Opioid Exposure

This study examines the effects of gestational opioid exposure on learning and memory in rats, finding spatial and associative learning impairments that can be mitigated by environmental enrichment in males.

Placental transcriptomics reveals alterations in metabolic and transport gene programs following prenatal cannabis smoke exposure

This study identifies subtle transcriptional changes in murine placentae following prenatal cannabis smoke exposure, affecting metabolic, transport, and regulatory pathways.

Spatial profiling and neurovascular communication in the developing and adolescent cortex following prenatal alcohol exposure

This study identifies gene expression and signaling changes in the neurovascular unit following prenatal alcohol exposure across development.

Changes in neuronal genes in prenatally alcohol-exposed placentas associate with neuropsychological traits at the age of six

The paper examines how prenatal alcohol exposure affects placental gene regulation and links these changes to neuropsychological traits in children at age six.

Prenatal cannabis exposure affects human fetal neurodevelopment: anintegrated multi-omics study

This study investigates the molecular effects of prenatal cannabis exposure on human fetal brains, finding significant disruptions in male second trimester brains linked to neurodevelopmental disorders.

Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain

This study compares the molecular effects of prenatal nicotine exposure and maternal smoking during pregnancy on mouse brain development and adulthood, finding distinct gene expression changes in pups but not adults.

Preconception Chronic Intermittent Ethanol Exposure Impacts Offspring Transcriptomes with Sex and Tissue Specific Effects

This study shows that preconception ethanol exposure affects offspring transcriptomes differently based on parent, sex, and tissue, indicating metabolic and immune issues.

Innovative Methods for Prenatal Cannabis Exposure: Vapor Inhalation Chamber and Metabolite Quantification in Prairie Voles and Rats

This study develops a cross-species inhalation protocol to expose pregnant prairie voles and rats to THC, showing placental transfer and species-specific distribution patterns.

Prenatal cannabinoid exposure induces sex-specific alterations in placental growth and lipid metabolism gene expression

This study shows that prenatal cannabinoid exposure leads to sex-specific changes in placental growth and lipid metabolism gene expression in rats.

Prenatal e-cigarette exposure induces region- and cell type-specific metabolic and developmental reprogramming

This study shows prenatal e-cigarette exposure causes region- and cell type-specific metabolic and developmental changes in neonatal rat brains, linked to neurodevelopmental disease risk.

Prenatal THC exposure disrupts mitochondrial respiratory gene programs and medium spiny neuron maturation trajectories in the nucleus accumbens

This study shows that prenatal THC exposure disrupts mitochondrial gene programs and medium spiny neuron maturation in the nucleus accumbens using snRNA-seq and snATAC-seq in a rat model.

Third Trimester-Equivalent Alcohol Exposure Reduces Neurons in Males and Increases Vglut2⁺ Neurons with Reduced Intrinsic Bursting in Females in The Murine Dorsal Subiculum

This study examines the effects of third-trimester-equivalent ethanol exposure on neuronal and VGLUT2+ cell density in the dorsal subiculum of male and female mice, finding sex-specific changes in neuronal density and excitability.

Moderate prenatal alcohol exposure differentially alters acute ethanol sensitivity of GABAergic transmission in CRFR1- and CRFR1+ CeM neurons

This study examines how moderate prenatal alcohol exposure alters acute ethanol effects on GABAergic transmission in CRFR1+ and CRFR1- CeM neurons in adult rats, showing sex-specific differences.

Epileptiform Discharges Drive High-frequency Oscillations Within the Retrosplenial Cortex of Mice with Third Trimester Alcohol Exposure

The paper identifies epileptiform discharges as a critical feature in a preclinical model of FASD, showing their relationship to high-frequency oscillations in the retrosplenial cortex.

Acute Ethanol Exposure Induces Stage-Specific Bioenergetic, Mitochondrial and Neurodevelopmental Transcriptional Remodeling in Human Forebrain Progenitors

This study shows that acute ethanol exposure causes stage-specific transcriptional changes in human forebrain progenitors, affecting mitochondrial and bioenergetic genes differently in early versus late progenitors.

Developmental Alcohol Exposure Alters Domains of Executive Function in Rodents

This study shows that developmental exposure to alcohol both prenatally and during adolescence leads to more severe deficits in executive function domains like disinhibition, working memory, and behavioral flexibility in rodents.

Age- and sex- dependent effects of moderate gestational day 12 prenatal alcohol exposure on anxiety-like behaviors, ethanol intake, and mechanical sensitivity

Unraveling a comparative landscape of protein-coding genes linked to neuroimmune function during adulthood consequent of prenatal alcohol exposure

This study identifies region-specific neuroimmune gene expression changes in adult mice following prenatal alcohol exposure, revealing proinflammatory pathways and transcriptional regulators linked to FASD.

Third Trimester-Equivalent Alcohol Exposure Induces Sex-Dependent Alterations in Locomotor Activity, Anxiety-Risky Behaviors, and Enhances Mechanical Allodynia in Adulthood

This study shows that third-trimester-equivalent alcohol exposure in neonatal mice leads to sex-dependent behavioral changes and increased mechanical allodynia in adulthood.

Melatonin Partially Attenuates Oxycodone-Induced Placental Stress Signaling and Fetal Brain Apoptosis in a Sex-Specific Manner.

This study examines how prenatal oxycodone exposure affects placental and fetal brain stress signaling and apoptosis, and whether melatonin can mitigate these effects in a sex-specific manner.

Delineating the effects of prenatal oxycodone exposure and melatonin treatment on placental and fetal outcomes in pregnant rats

This study examines the effects of prenatal oxycodone exposure and melatonin treatment on placental and fetal outcomes in rats, finding that oxycodone impairs fetal growth and placental structure, with partial melatonin mitigation.

Mechanical Properties of the Developing Brain in a Model of Fetal Alcohol Spectrum Disorders and Relationships to Perineuronal Net Integrity

This study uses magnetic resonance elastography to assess brain mechanical properties and perineuronal net density in a rat model of FASD, showing reduced stiffness in alcohol-exposed rats that recovers by adulthood.

Hippocampal Development in a Rat Model of Perigestational Opioid Exposure

This study examines the effects of perigestational morphine exposure on hippocampal development in rats, finding delayed neuronal maturation and altered BDNF expression, which can be mitigated by environmental enrichment.

Prenatal Polysubstance Exposure Alters Behaviour in Zebrafish Larvae

This study shows that prenatal exposure to multiple drugs in zebrafish larvae leads to complex, stage-dependent behavioral changes that cannot be predicted from single-drug effects.

Comparative Analysis of Test Tube and Volumetric Drinking Monitor Methods in Voluntary Ethanol Consumption in Female Mice for Prenatal Alcohol Exposure

This study compares ethanol consumption and blood alcohol concentrations in female mice using test tubes and a volumetric drinking monitor, finding no significant differences between the methods.