Prenatal Substance Exposure Effects

Learning and Memory Performance in a Rat Model of Perigestational Opioid Exposure

This study examines the effects of gestational opioid exposure on learning and memory in rats, finding spatial and associative learning impairments that can be mitigated by environmental enrichment in males.

Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain

This study compares the molecular effects of prenatal nicotine exposure and maternal smoking during pregnancy on mouse brain development and adulthood, finding distinct gene expression changes in pups but not adults.

Innovative Methods for Prenatal Cannabis Exposure: Vapor Inhalation Chamber and Metabolite Quantification in Prairie Voles and Rats

This study develops a cross-species inhalation protocol to expose pregnant prairie voles and rats to THC, showing placental transfer and species-specific distribution patterns.

Third Trimester-Equivalent Alcohol Exposure Reduces Neurons in Males and Increases Vglut2⁺ Neurons with Reduced Intrinsic Bursting in Females in The Murine Dorsal Subiculum

This study examines the effects of third-trimester-equivalent ethanol exposure on neuronal and VGLUT2+ cell density in the dorsal subiculum of male and female mice, finding sex-specific changes in neuronal density and excitability.

Moderate prenatal alcohol exposure differentially alters acute ethanol sensitivity of GABAergic transmission in CRFR1- and CRFR1+ CeM neurons

This study examines how moderate prenatal alcohol exposure alters acute ethanol effects on GABAergic transmission in CRFR1+ and CRFR1- CeM neurons in adult rats, showing sex-specific differences.

Developmental Alcohol Exposure Alters Domains of Executive Function in Rodents

This study shows that developmental exposure to alcohol both prenatally and during adolescence leads to more severe deficits in executive function domains like disinhibition, working memory, and behavioral flexibility in rodents.

Mechanical Properties of the Developing Brain in a Model of Fetal Alcohol Spectrum Disorders and Relationships to Perineuronal Net Integrity

This study uses magnetic resonance elastography to assess brain mechanical properties and perineuronal net density in a rat model of FASD, showing reduced stiffness in alcohol-exposed rats that recovers by adulthood.

Prenatal Polysubstance Exposure Alters Behaviour in Zebrafish Larvae

This study shows that prenatal exposure to multiple drugs in zebrafish larvae leads to complex, stage-dependent behavioral changes that cannot be predicted from single-drug effects.

Comparative Analysis of Test Tube and Volumetric Drinking Monitor Methods in Voluntary Ethanol Consumption in Female Mice for Prenatal Alcohol Exposure

This study compares ethanol consumption and blood alcohol concentrations in female mice using test tubes and a volumetric drinking monitor, finding no significant differences between the methods.

Prenatal cannabis smoke exposure alters placental development in a murine model of pregnancy

This study shows that prenatal cannabis smoke exposure in mice reduces placental size and function and affects fetal brain growth.

Endothelial NMDA receptor involvement in retinal neurovascular damage following prenatal alcohol exposure in mouse model

This study shows that endothelial NMDA receptors are critical for retinal vascular development and mediate prenatal alcohol exposure-induced neurovascular defects in mice.

ACSS2 mediates prenatal alcohol exposure-related morphological and behavioral phenotypes

This study identifies ACSS2 as a mediator of prenatal alcohol exposure-related phenotypes, showing its role in histone acetylation and developmental changes in the brain.

Adolescent intermittent ethanol exposure induces sex-specific and time-dependent changes in affective behaviors and metabolomic profiles.

This study examines sex-specific and time-dependent behavioral and metabolomic changes in mice after adolescent binge ethanol exposure.

Alcohol Disrupts Neural Differentiation Through Endoplasmic Reticulum Stress and PERK Pathway Activation

This study shows alcohol disrupts neural differentiation by inducing ER stress and PERK pathway activation in both in vitro and in vivo models of prenatal alcohol exposure.

Nicotine in E-Cigarette Aerosol Reduces GABA Neuron Migration via the α7 Nicotinic Acetylcholine Receptor

This study shows that e-cigarette aerosol exposure during pregnancy reduces GABA neuron migration via α7 nAChR activation, highlighting risks for neurodevelopment.

Interactions between the Bone Morphogenetic Protein and the Planar Cell Polarity Pathways lead to distinctive ethanol-induced facial defects

This study investigates how ethanol affects facial development in zebrafish by examining interactions between the BMP and PCP pathways during specific developmental time windows.

Prenatal alcohol exposure dysregulates the expression of clock genes and alters rhythmic behaviour in mice

This study shows that prenatal alcohol exposure disrupts circadian rhythms and gene expression in mice, affecting behavior and memory.

Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study

This study examines the effects of prenatal THC exposure on mouse brain development using MRI across the lifespan, finding sex-dependent neurodevelopmental impacts.

Perinatal fluoxetine exposure increases male rat sexual behavior

This study shows that perinatal fluoxetine exposure increases sexual behavior in adult male rats, suggesting long-term effects of serotonin on sexual function.

Prenatal Alcohol Exposure Impairs Striatal Cholinergic Function and Cognitive Flexibility in Adult Offspring

This study shows that prenatal alcohol exposure reduces cholinergic interneurons and their activity in the striatum, leading to impaired cognitive flexibility and compulsive drinking behaviors in adult offspring.

Early Life Outcomes of Prenatal Exposure to Alcohol and Synthetic Cannabinoids in Mice

This study examines the effects of prenatal alcohol and synthetic cannabinoid co-exposure on mouse offspring survival, physical development, and neurobehavioral outcomes, finding increased mortality and sex-specific behavioral impairments.

Perinatal Fentanyl Exposure Drives Enduring Addiction Risk and Central Amygdala Gene Dysregulation

This study shows that perinatal fentanyl exposure in rats leads to long-term addiction risk and central amygdala gene dysregulation, providing insights into the molecular mechanisms of NOWS and its consequences.

The acoustic properties, syllable structure, and syllable sequences of ultrasonic vocalizations (USVs) during neonatal opioid withdrawal in FVB/N mouse substrains

This study examines ultrasonic vocalizations (USVs) in FVB/N mouse pups during neonatal opioid withdrawal, identifying syllable sequences and acoustic properties linked to withdrawal severity.

Disrupted Maternal Behavior in Morphine-Dependent Pregnant Rats and Anhedonia in their Offspring

This study examines the effects of perinatal morphine exposure on maternal behavior and offspring anhedonia in rats, finding disrupted maternal behavior and reduced sucrose preference in offspring.

Effects of alcohol on the transcriptome, methylome, and metabolome of in vitro gastrulating human embryonic cells

This study examines how alcohol exposure affects the transcriptome, methylome, and metabolome of human embryonic cells during gastrulation, identifying key gene and metabolic changes linked to fetal alcohol spectrum disorders.

Ethanol down-regulates gastrula gene expression and cell movement, causing symptoms of foetal alcohol spectrum disorders

This study shows ethanol disrupts gastrula gene expression and cell movement in zebrafish, leading to developmental defects similar to human FASDs.

Prenatal cannabinoid exposure affects central cardiorespiratory control in young male and female rats

This study shows that prenatal cannabinoid exposure impairs respiratory and autonomic control in juvenile rats, with sex-specific effects on reflex responses to hypoxia and hypercapnia.

Ethanol induces craniofacial defects in Bmp mutants independent of nkx2.3 by elevating cranial neural crest cell apoptosis

The ultrasonic vocalization (USV) syllable profile during neonatal opioid withdrawal and a kappa opioid receptor component to increased USV emissions in female mice

This study examines USV profiles and kappa opioid receptor involvement in neonatal opioid withdrawal in female mice, finding increased Complex 3 syllables and female-specific KOR system activation.

Sex-Specific DNA Methylation and Gene Expression Changes in Mouse Placentas After Early Preimplantation Alcohol Exposure

This study examines sex-specific DNA methylation and gene expression changes in mouse placentas after early preimplantation alcohol exposure, finding significant differences in molecular profiles between male and female placentas.