Prenatal Substance Exposure Effects

Prenatal Alcohol Exposure Downregulates Focal Adhesion Molecules Tensin 1 and Tensin 2 Contributing to Cerebrovascular Dysfunction

This study shows prenatal alcohol exposure reduces Tns1 and Tns2 in brain microvascular endothelial cells, impairing angiogenesis, and that miR-150-5p mediates this effect.

Automated pup-level analysis reveals distinct effects of prenatal CBD and THC exposure on maternal retrieval

This study uses automated analysis to show that prenatal CBD and THC exposure leads to distinct effects on maternal retrieval behavior in mice, with compound-specific changes in kinematics and learning.

Prenatal alcohol and cannabinoid co-exposure increases ethanol-seeking in adult offspring and produces sex-dependent medial prefrontal cannabinoid receptor 1 expression.

This study shows that prenatal exposure to both alcohol and cannabinoids increases ethanol-seeking behavior in adult male offspring and alters cannabinoid receptor expression in the medial prefrontal cortex.

Transcriptomic Analysis of the Newborn Mammary Gland Identifies Prenatal Ethanol-Induced Remodeling of Insulin Signaling and Enhanced Proliferative Programming

This study identifies prenatal ethanol-induced molecular reprogramming in newborn mammary glands, including altered insulin signaling and enhanced proliferative programming.

Prenatal fentanyl and Δ9-tetrahydrocannabinol exposure disrupt placental function and fetal growth in a mouse model of multidrug use

This study shows that prenatal exposure to fentanyl and THC in mice impairs placental function and causes fetal growth restriction, with the greatest effects seen when both drugs are used together.

Placental transcriptomics reveals alterations in metabolic and transport gene programs following prenatal cannabis smoke exposure

This study identifies subtle transcriptional changes in murine placentae following prenatal cannabis smoke exposure, affecting metabolic, transport, and regulatory pathways.

Spatial profiling and neurovascular communication in the developing and adolescent cortex following prenatal alcohol exposure

This study identifies gene expression and signaling changes in the neurovascular unit following prenatal alcohol exposure across development.

Changes in neuronal genes in prenatally alcohol-exposed placentas associate with neuropsychological traits at the age of six

The paper examines how prenatal alcohol exposure affects placental gene regulation and links these changes to neuropsychological traits in children at age six.

Prenatal cannabis exposure affects human fetal neurodevelopment: anintegrated multi-omics study

This study investigates the molecular effects of prenatal cannabis exposure on human fetal brains, finding significant disruptions in male second trimester brains linked to neurodevelopmental disorders.

Preconception Chronic Intermittent Ethanol Exposure Impacts Offspring Transcriptomes with Sex and Tissue Specific Effects

This study shows that preconception ethanol exposure affects offspring transcriptomes differently based on parent, sex, and tissue, indicating metabolic and immune issues.

Prenatal cannabinoid exposure induces sex-specific alterations in placental growth and lipid metabolism gene expression

This study shows that prenatal cannabinoid exposure leads to sex-specific changes in placental growth and lipid metabolism gene expression in rats.

Prenatal e-cigarette exposure induces region- and cell type-specific metabolic and developmental reprogramming

This study shows prenatal e-cigarette exposure causes region- and cell type-specific metabolic and developmental changes in neonatal rat brains, linked to neurodevelopmental disease risk.

Prenatal THC exposure disrupts mitochondrial respiratory gene programs and medium spiny neuron maturation trajectories in the nucleus accumbens

This study shows that prenatal THC exposure disrupts mitochondrial gene programs and medium spiny neuron maturation in the nucleus accumbens using snRNA-seq and snATAC-seq in a rat model.

Epileptiform Discharges Drive High-frequency Oscillations Within the Retrosplenial Cortex of Mice with Third Trimester Alcohol Exposure

The paper identifies epileptiform discharges as a critical feature in a preclinical model of FASD, showing their relationship to high-frequency oscillations in the retrosplenial cortex.

Acute Ethanol Exposure Induces Stage-Specific Bioenergetic, Mitochondrial and Neurodevelopmental Transcriptional Remodeling in Human Forebrain Progenitors

This study shows that acute ethanol exposure causes stage-specific transcriptional changes in human forebrain progenitors, affecting mitochondrial and bioenergetic genes differently in early versus late progenitors.

Age- and sex- dependent effects of moderate gestational day 12 prenatal alcohol exposure on anxiety-like behaviors, ethanol intake, and mechanical sensitivity

Unraveling a comparative landscape of protein-coding genes linked to neuroimmune function during adulthood consequent of prenatal alcohol exposure

This study identifies region-specific neuroimmune gene expression changes in adult mice following prenatal alcohol exposure, revealing proinflammatory pathways and transcriptional regulators linked to FASD.

Third Trimester-Equivalent Alcohol Exposure Induces Sex-Dependent Alterations in Locomotor Activity, Anxiety-Risky Behaviors, and Enhances Mechanical Allodynia in Adulthood

This study shows that third-trimester-equivalent alcohol exposure in neonatal mice leads to sex-dependent behavioral changes and increased mechanical allodynia in adulthood.

Melatonin Partially Attenuates Oxycodone-Induced Placental Stress Signaling and Fetal Brain Apoptosis in a Sex-Specific Manner.

This study examines how prenatal oxycodone exposure affects placental and fetal brain stress signaling and apoptosis, and whether melatonin can mitigate these effects in a sex-specific manner.

Delineating the effects of prenatal oxycodone exposure and melatonin treatment on placental and fetal outcomes in pregnant rats

This study examines the effects of prenatal oxycodone exposure and melatonin treatment on placental and fetal outcomes in rats, finding that oxycodone impairs fetal growth and placental structure, with partial melatonin mitigation.

Hippocampal Development in a Rat Model of Perigestational Opioid Exposure

This study examines the effects of perigestational morphine exposure on hippocampal development in rats, finding delayed neuronal maturation and altered BDNF expression, which can be mitigated by environmental enrichment.

A single binge ethanol exposure is apoptotic within hours across neurodevelopment and partially regulated by the Myt1l gene.

The paper shows a single binge ethanol exposure rapidly increases apoptosis in early adolescent and adult mice, with Myt1l haploinsufficiency modulating this effect across developmental stages.

Concurrent maternal stress and THC exposure during pregnancy alters adolescent behavioral outcomes and corticolimbic molecular programs

This study shows that prenatal THC exposure and maternal stress impair maternal behavior and alter offspring neurodevelopment with sex- and region-specific molecular changes.

Sodium Butyrate Rescues Neurodevelopmental Deficits Following Perinatal Methadone Exposure

This study shows that sodium butyrate reduces neurodevelopmental deficits in rats exposed to methadone prenatally by improving gut-brain axis function and myelination.

Large-Scale In Vivo Electrophysiology and Dimensionality-Reduction Analysis Reveal Opposing Thalamic and Hippocampal Excitability After Third-Trimester-Equivalent Alcohol Exposure in Mice

The paper uses in vivo electrophysiology and dimensionality reduction to show alcohol exposure reduces firing rates in thalamic neurons but increases hippocampal excitability in mice.

Longitudinal mapping of cortical change during early adolescence associated with prenatal tobacco and/or alcohol exposure in the Adolescent Brain Cognitive DevelopmentSM Study

This study examines how prenatal tobacco and alcohol exposure affects cortical structure and development in early adolescence using longitudinal data from the ABCD Study.

Moderate prenatal alcohol exposure alters GABAergic transmission and the action of acute alcohol in the CeM of adolescent rats

This study investigates how prenatal alcohol exposure (PAE) affects GABAergic transmission and acute alcohol's effects in the CeM of adolescent rats, revealing sex-specific changes in synaptic activity.

Ethanol exposure model in zebrafish causes phenotypic, behavioral and gene expression changes that mimic Fetal Alcohol Spectrum Disorders in human birth cohorts

Deliberative Behaviors and Prefrontal-Hippocampal Coupling are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders

This study shows that third trimester alcohol exposure in rats disrupts prefrontal-hippocampal oscillatory interactions and choice behaviors during a working memory task.

The Negative Effects of Smoking Cigarettes on Morphological and Histological Damages to 18 and 21 Days Mouse Embryo Liver

This study examines the effects of cigarette smoke exposure on mouse embryo liver morphology and histology at 18 and 21 days, finding significant cellular and structural damage.