Lipid metabolism and biosynthesis

The paper shows MBOAT7 redistributes to ER-LD contacts via RAB1 to inhibit DGAT2-mediated lipid droplet growth in response to CDS2 disruption.

The paper evaluates four fluorophores for visualizing lipid droplets in an extremophilic green alga, finding that Cou and DPAS offer strong specificity and low toxicity, while BODIPY and DAF have distinct limitations.

The paper characterizes SFDs in setaphytes, showing they desaturate VLCFAs in sphingolipids and glycerolipids, likely via acyl-CoA substrates, and suggests renaming them VFADs.

The paper demonstrates that the lipid droplet assembly complex (LDAC) catalyzes oil-phase formation in membranes, enabling organized lipid droplet formation.

This study identifies SPF1/2 SUMO proteases that inhibit seed filling and fatty acid biosynthesis by deSUMOylating WRI1, enhancing its degradation and reducing oil accumulation in Arabidopsis.

This study uses metabolic modeling to show that glycolytic shunts correct cofactor imbalance in triacylglycerol biosynthesis, enabling higher biosynthetic rates in oilseeds.

This study identifies a dominant CIDEC variant causing familial obesity by increasing lipid droplet size in adipocytes through structural and functional changes.

This study investigates the role of CLRP23 in cold acclimation of Arabidopsis thaliana, showing its involvement in lipid remodeling and integration of membrane and metabolic responses.

This study identifies TMEM263 as an ER-resident protein essential for lipid droplet formation and growth, showing its role in lipid condensation and organismal development.

This study shows that Gcn4 regulates SAM allocation between phospholipid and histone methylation during methionine-supplemented growth in yeast.

This study examines lipid polarity and droplet changes in hippocampal neurons across aging and Alzheimer's disease models, finding altered lipid dynamics in AD-transgenic mice.

The paper investigates lipid droplet (LD) metabolism in an AD model and finds altered LD dynamics contribute to mitochondrial dysfunction and cell dyshomeostasis.

This study identifies Nsg1, Nsg2, and Ypf1 as glucose starvation-specific factors at the yeast nucleus-vacuole junction, revealing their role in regulating Hmg1 and Hmg2 through membrane remodeling and sterol biosynthesis.

This study investigates changes in the plastoglobule lipidome and proteome of water-deficient maize over time, identifying key lipids and proteins involved in adaptive responses to drought.

This study expresses Brassica juncea FAE1 isozymes in yeast and algae to assess their activity, finding that only yeast supports VLCFA biosynthesis, highlighting host-dependent enzyme function.

This paper shows lipid droplets (LDs) are sites of active protein translation and demonstrate that LD-associated translation is regulated during Mycobacterium tuberculosis infection.

This study identifies Pln1 as a mediator of lipid droplet-vacuole tethering during microlipophagy in Saccharomyces cerevisiae, revealing its role in LD degradation and survival under starvation.

This study identifies a dual-site membrane recognition mechanism in ABHD5 that enables its activation and regulation of lipid metabolism.

The paper examines mRNA, protein, and lipogenesis activity in hepatocytes during feeding and starvation, finding widespread discordance between mRNA and protein levels, especially in sex-biased genes and lipogenic pathways.

ExSPM reveals spatiotemporal heterogeneities in lipid droplet polarity, showing dynamics and pathway-specific kinetics of lipid metabolism.

This study shows that the EMC3 subunit is critical for lipid droplet homeostasis in mice and Drosophila, with loss of EMC3 causing triglyceride storage defects and reduced FITM2 levels.

This study compares lipidomes of five yeast strains, finding significant differences in lipid classes and molecular species, with transcriptomic data suggesting post-transcriptional regulation.

This study identifies Hoi1 as an adaptor that targets BLTP2-like proteins to ER-PM contact sites in yeast, regulating lipid homeostasis and showing conservation in worms and flies.

This study shows that lipid droplet accumulation during sepsis enhances antibacterial innate immunity by promoting bacterial clearance and pro-inflammatory responses through DGAT1-dependent mechanisms.

This study shows a BCFA-rich diet in C. elegans causes enlarged lipid droplets, developmental delays, reduced reproduction, and shorter lifespan.

The paper identifies 410 yeast gene deletion mutants hypersensitive to HEH, revealing 21 genes epistatically interacting with PtdCho methylation pathway enzymes.

This study shows that archaea can synthesize fatty acids using a newly identified pathway and enzyme complex, providing insights into their evolutionary lipid composition.

The paper investigates the role of VPS28 in triglyceride synthesis through modulation in bovine cells and a mouse model, showing its regulation via the ubiquitination pathway.

This study identifies AtVPS13M1 as a lipid transporter in Arabidopsis thaliana that affects phospholipid degradation during phosphate starvation and localizes to mitochondria.

This paper shows that blocking lipid synthesis in Drosophila fat body triggers a metabolic switch to glycogen storage, mediated by SREBP and HATs, supporting development but reducing lifespan and fecundity.