Axon Guidance and Neuronal Signaling

Electrically Contrasting Periodic Polymer Interfaces Guide Neuronal Networks

This study shows that periodic polymer stripes with electrical contrasts influence neuronal network formation by guiding axonal growth and synapse formation.

Tachykinin neuropeptides are involved in axonal and synaptic differentiation of the pioneer motor axon in zebrafish

This study investigates the role of tachykinin neuropeptides in axonal and synaptic differentiation of zebrafish motor axons, finding that tac1 disruption leads to axonal abnormalities and increased motor neuron activity.

MIGRATION OF SCHWANN CELL PRECURSORS (SCPs) IS REGULATED BY INTERACTIONS OF N-CADHERIN-MEDIATED ADHESION AND EPHRIN-A2-INDUCED SCP CONTRACTILITY

The paper shows that Schwann cell precursor migration is controlled by N-cadherin-mediated adhesion and ephrin-A2-induced contractility.

LIN-44/Wnt controls developmental neurite pruning via UNC-43/CaMKII and PKC-2/PKC in C. elegans

This study identifies the Wnt-calcium signaling pathway as essential for stereotyped neurite pruning in C. elegans, showing its regulation by lin-44/Wnt and involvement of unc-43/CaMKII and pkc-2/PKC.

Proteomic profile of hippocampal growth cones through early postnatal development

The paper profiles the proteomic changes in hippocampal and dentate gyrus growth cones across early postnatal development in mice, identifying key proteins and developmental trajectories.

Encoding neuronal shape in the stochastic dynamics of branching processes

The paper shows how stochastic dynamics and cytoskeletal regulation shape distinct neuronal morphologies in Drosophila mechanosensory neurons.

Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology

The paper links neural birth timing and somatosensory circuit assembly through Robo3 regulation of dendrite morphology in Drosophila.

PCP-dependent polarity propagation across neuronal columns in the Drosophila medulla

The paper shows PCP-dependent polarity propagation across discontinuous neuronal columns in Drosophila medulla using genetic manipulations and developmental analysis.

The Cxcl14 chemokine defines pioneer axon guidance and early circuit assembly in the inner ear

This study identifies Cxcl14 as a chemokine guiding pioneer axons in inner ear circuit formation and shows its role in axon navigation and mechanosensory behavior.

The unconventional kinesin Kif26a is required for the guidance of major axon tracts in the developing mouse brain

This study shows Kif26a is required for axon tract guidance in the developing mouse brain, with defects similar to the Fzd3-Celsr3-Dystroglycan pathway.

The Cappuccino interactome reveals an intracellular role for Semaphorin-2a in Drosophila oogenesis

This study identifies an intracellular role for Semaphorin-2a in Drosophila oogenesis by inhibiting Cappuccino-mediated actin polymerization and affecting oskar mRNA localization.

The role of the roof plate for mesencephalic trigeminal neuron

This study investigates how MTN axons avoid crossing the roof plate, finding that SLIT2-ROBO2 signaling prevents this and maintains cell bodies near the roof plate.

Axonal growth of cortical neurons does not require paxillin

This study shows that paxillin is not required for axonal growth in cortical neurons during development, as knockout mice showed no significant changes in axon length or morphology under basal conditions.

Inverse expression of Ten3 and Lphn2 across the developing mouse brain suggests a global strategy for circuit assembly

The paper identifies inverse expression of Ten3 and Lphn2 in the developing mouse brain and shows their expression patterns predict connectivity in neural circuits.

Ten3-Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly

The paper shows how Ten3 and Lphn2 mediate target selection in extended hippocampal networks through attraction and repulsion mechanisms, enabling repeated circuit assembly strategies.

Identifying molecular instructions to hard-wire a sensory neurons synaptic connectivity

The paper identifies cell surface molecules that distinguish Drosophila sensory neurons and shows how their expression patterns influence synaptic connectivity.

Sequestration of growth cone surface proteins by cytoplasmic Lrrtm2 induces de novo amygdala innervation by cerebral cortex associative neurons

The paper identifies how Lrrtm2 sequestration in growth cones disrupts axon guidance, leading to abnormal amygdala innervation in callosal projection neurons, linking Bcl11a deletion to ASD/ID mechanisms.

Fgf3 and Fgf10a regulate neuronal fasciculation through Schwann cell proliferation and infiltration in zebrafish posterior lateral line

Gαi2 coordinates neuronal microtubule and neurofilament networks to regulate axon initiation in vivo

This study shows that Gαi2 coordinates neurofilament and microtubule networks to regulate axon initiation in developing chick spinal cord.

Distinct postsynaptic morphogenetic strategies across Drosophila embryonic muscles during neuromuscular junction formation

The paper examines postsynaptic morphogenetic strategies in Drosophila embryonic muscles during neuromuscular junction formation, revealing distinct myopodial organization across different muscle types.

EPHA2-Ephrin-B1 cis-interaction supports self-renewal ability leading to recurrence of oral cancer.

This study identifies Ephrin-B1-EPHA2 cis-interaction as a driver of oral cancer self-renewal and recurrence, validated through proteomics, biochemical assays, and clinical data.

Diverse and Location-Specific Roles of PlexinA2, PlexinA4, and NCAM in Developing Hippocampal Mossy Fibers

This study investigates the roles of PlexinA2, PlexinA4, and NCAM in the development of mossy fibers in the hippocampus, revealing distinct and overlapping functions in axon bundling and targeting.

Laminin and BDNF synergistically induce local translation in axonal growth cones

The paper shows laminin and BDNF synergistically increase local translation in axonal growth cones, with isoform-specific effects on translation and axon guidance.

Nematode Extracellular Protein Interactome Expands Connections between Signaling Pathways

The paper reports a C. elegans extracellular interactome dataset, revealing new interactions between signaling pathways and potential roles in human disease mechanisms.

A glial cell derived pathway directs regenerating optic nerve axons toward the optic chiasm

This study identifies a glial-derived pathway involving Lh3 and Col18a1 that guides regenerating optic nerve axons toward the optic chiasm in zebrafish.

Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex

The paper identifies context-specific subcellular RNA regulation in growth cones of developing cortical neurons and links it to neurodevelopmental disorders.

Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one Pcdhg isoform

The paper investigates the role of specific Pcdhg isoforms in neuronal self-avoidance and survival in mouse starburst amacrine cells, finding that {gamma}C4 is essential for survival but not self-avoidance.

Proteinaceous Metal-Binding Eph-Ephrin Tetramerization is Modulated by Copper and Chelators

The paper identifies EphrinB2 as a copper-binding protein that modulates Eph-Ephrin tetramerization through interactions with copper and chelators.

Eph-Ephrin Tetramerization Inhibitors Target Bidirectional Signaling to Combat Pain and Addiction

The paper identifies 8-hydroxyquinoline compounds that disrupt EphB-EphrinB tetramer interactions, reducing bidirectional signaling and alleviating pain and opioid withdrawal.

Cyfip2 mediates sensorimotor integration of visual input through Rac1-dependent actin remodeling

This study identifies Cyfip2's role in visual sensorimotor circuit development in zebrafish, showing it mediates actin remodeling via Rac1 to enable visually-driven behaviors.