Axon Guidance and Neuronal Signaling

Evolutionary conservation of midline axon guidance activity between Drosophila and Tribolium Frazzled

This study shows that Tribolium Frazzled can substitute for Drosophila Frazzled in promoting midline axon crossing, suggesting conserved mechanisms in insect axon guidance.

Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development

This study identifies the Slit2-Robo1 pathway as critical for cardiac sympathetic innervation during development, showing reduced innervation in Slit2-/- and Robo1-/- mice.

Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish

The paper identifies col18a1a as a factor guiding axonal defasciculation during zebrafish nerve regeneration, specifically at branching points near neuromasts.

Modularity in the DCC extracellular domain elicits distinct effects on axon guidance

The paper shows that distinct modules in the DCC extracellular domain are essential for specific axon guidance functions in mice.

A dendritic guidance receptor functions in both ligand dependent and independent modes

This study shows that the dendritic guidance receptor DMA-1 functions both ligand-dependently and -independently, promoting stochastic outgrowth and stabilizing stereotyped dendritic morphology.

A critical affinity window for IgSF proteins DIP-alpha and Dpr10 is required for proper motor neuron arborization

The paper shows that specific affinity ranges for IgSF proteins DIP- and dpr10 are critical for proper motor neuron arborization in flies.

SAX-7/L1CAM acts with the adherens junction proteins MAGI-1, HMR-1/Cadherin, and AFD-1/Afadin to promote glial-mediated dendrite extension

The paper identifies a multivalent adhesion complex in glia that promotes dendrite extension through interactions involving SAX-7/L1CAM, MAGI-1, HMR-1/Cadherin, and AFD-1/Afadin.

Axon-specific mRNA translation shapes dopaminergic circuit development

The paper identifies axon-specific mRNA translation in dopaminergic neurons and shows how it regulates axon development and connectivity.

Functional Role for Cas Cytoplasmic Adaptor Proteins During Cortical Axon Pathfinding

This paper identifies Cas adaptor proteins as essential for fasciculation and guidance of cortical axon tracts, with distinct cellular roles in different pathways.

The actin assembly regulator toca-1 regulates collateral branching in C. elegans

This study identifies TOCA-1 as a regulator of collateral branching in C. elegans neurons, showing it promotes actin assembly through WASP-1 and Arp2/3 complex activation.

Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression

The paper shows that Robo3 expression in spinal commissural neurons is controlled by gene regulatory networks involving incoherent feedforward and feedback loops, which determine midline crossing.

Evolutionary conservation of midline repulsive signaling by Robo family receptors inflies and mice

This study shows that Robo family receptors from mice can partially rescue midline repulsion in fruit flies, suggesting conserved core mechanisms but also evolutionary divergence.

Tyrosine phosphorylation and the inhibitory C-terminal SAM domain moderately affect transient interactions in a EphA2 cytoplasmic fragment in solution: A combined experimental and molecular modeling study.

This study investigates the structural dynamics of the EphA2 intracellular fragment, showing phosphorylation affects transient interactions and signaling potential.

Computational Modeling of Motor-Driven Extension of Microtubule Bundles in Axons

This study uses a computational model to show that intermediate cross-linking density and microtubule stiffness maximize axonal outgrowth by balancing buckling resistance and mechanical load.

Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in Drosophila larvae

The paper shows that Wnt/Fz signaling regulates segment-specific axon guidance in Drosophila larvae, diversifying motor commands for forward and backward locomotion.

Capicua refines mossy fiber-CA3 axon targeting in the late postnatal hippocampus

This study shows that CIC deletion causes abnormal mossy fiber targeting in the mouse hippocampus after the second postnatal week, due to loss of a mature granule neuron subtype and dysregulation of axon guidance genes.

Comparative developmental transcriptomics of Drosophila mushroom body neurons highlights the mevalonate pathway as a regulator of axon growth

The paper compares axon growth programs in Drosophila mushroom body neurons using transcriptomics, identifying the mevalonate pathway as critical for axon regrowth.

Sequoia affects Drosophila central nervous system development by regulating axonal extension and guidance

This study identifies new sequoia alleles and shows that seq mutations affect CNS development, axonal outgrowth, and morphology in Drosophila.

Nascent dendrite branches initiated by a localized burst of Spire-dependent actin polymerization.

The paper shows Spire promotes dendrite branching by linking actin polymerization to endosomal trafficking in Drosophila neurons.

Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis

This study identifies Coro1A and TRIM67 as collaborators in netrin-dependent neuronal morphogenesis, showing their interaction is required for netrin responses.

Nanotopographic Control of Actin Waves and Growth Cone Navigation in Developing Neurons

This study examines how nanotopography influences actin wave dynamics and neurite navigation in developing neurons, showing reduced responsiveness to physical cues as neurons mature.

Teneurin-4 switches between self-recognition and canonical Latrophilin binding to direct neuronal migration

The paper shows how Ten4 switches between self-recognition and Latrophilin binding to guide neuronal migration through exclusive structural interactions.

Axon termination of the SAB motor neurons in C. elegans depends on pre- and postsynaptic activity

The paper shows that muscle activity influences axon termination in C. elegans SAB neurons through retrograde signals and calcium dynamics.

Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity

This study generates a Klhl14-Cre mouse line to selectively identify and investigate a specific subpopulation of corticospinal neurons during development and into maturity.

Src/Fas2-dependent Ephrin phosphorylation initiates Eph/Ephrin reverse signaling through Rac1 to shape columnar units in the fly brain

This study identifies a bi-directional Ephrin/Eph signaling mechanism involving Src/Fas2-dependent Ephrin phosphorylation and Rac1 to regulate columnar neuron morphology and positioning in the fly brain.

A molecular basis of somatotopic map formation

This study identifies teneurin-3 and latrophilin-2 as key molecules in forming the somatotopic map in the mouse spinal cord, showing their role in neuronal connectivity and body localization.

EphA2 and Ephrin-A1 Use the Same Interface for Both in cis and in trans Interactions That Regulate Distinct Cell Signaling and Function

This paper identifies a shared interface for EphA2-ephrin-A1 cis and trans interactions, showing cis interactions inhibit trans signaling and contribute to oncogenesis.

Spatiotemporal Coordination of Guidance Cues Directs Multipolar Migration During Retinal Lamination

The paper investigates how guidance cues coordinate multipolar migration in developing retinal neurons, revealing repulsive and attractive signaling pathways that guide proper lamination.

A neurovascular template guides the spatial and functional compartmentalization of the adrenal gland

The paper shows that neurovascular signals guide adrenal gland compartmentalization by shaping vascular domains that direct hormone-producing cells to their correct territories.

Midline Assembloids Reveal Regulators of Human Axon Guidance

The paper develops a human midline assembloid model to study axon guidance and identifies GALNT2 as a human-specific regulator of commissural axon guidance.