Caveolin-1 and cellular processes

Membrane Curvature Generation by the Caveolin 8S Complex and the Role of Cholesterol

This study shows the 8S caveolin complex generates positive membrane curvature through a conical shape, with cholesterol affecting curvature via stress relief rather than direct binding.

Structures of EHD2 filaments on curved membranes provide a model for caveolar neck stabilization

This study uses cryo-electron tomography to reveal the structure of EHD2 filaments on curved membranes, showing how they stabilize caveolar necks and their role in cellular dynamics.

Membrane Remodeling by the Collective Action of Caveolin-1

This study develops a coarse-grained model to investigate how caveolin-1 proteins drive membrane curvature through collective interactions.

Remote Control of Cell Signaling through Caveolae Mechanics

The paper investigates how mechanical stress affects caveolae mechanics, leading to the release of caveolin-1 scaffolds and modulation of signaling pathways like JAK1, eNOS, PTEN, and PTP1B.

CLIC-dependent internalization of caveolin-1 to lysosomal vacuoles in response to osmotic regulation

The paper shows that caveolin-1 is internalized via CLIC-dependent endocytosis to lysosomal vacuoles in response to osmotic changes, defining a new recycling pathway for membrane buffering.

BIN1 overexpression rescues cardiac but not skeletal muscle defects in a mouse model of caveolinopathy

This study shows BIN1 overexpression improves cardiac but not skeletal muscle function in Cav-3 knockout mice, highlighting tissue-specific therapeutic responses in caveolinopathies.

Proline 110 is necessary for maintaining a compact helical arrangement in caveolin-1

The paper investigates the structural role of Proline 110 in caveolin-1 by analyzing conformational changes using FRET and static light scattering.

Mechanism of membrane curvature generation and caveola formation by flat disc-like complexes of caveolin

This study proposes a mechanism by which caveolin discs generate membrane curvature and caveola formation through lipid monolayer interactions and elastic stresses.

Seipin Regulates Caveolin-1 Trafficking and Organelle Crosstalk

This study shows that seipin regulates CAV1 trafficking and organelle interactions by controlling lipid metabolism and membrane order, impacting cellular homeostasis and metabolic disorders.

Mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signaling in Caveolin-1 null mice

This study investigates how the absence of Caveolin-1 affects mammary gland metabolism and its impact on fetoplacental cytokine signaling through integrative metabolomics and transcriptomics analyses.

Seeking the Membrane-Bound Structure of the Caveolin 8S Complex

This study validates the scaffolding mechanism of the 8S complex in generating membrane curvature through all-atom simulations, showing it adopts a conical shape with lipid interactions.

Unsaturated lipids as key control points for caveola formation and disassembly

This study identifies specific unsaturated lipids as critical for caveola formation and their disassembly under oxidative stress.

Caveolin assemblies displace one bilayer leaflet to organize and bend membranes

This paper investigates how the CAV1-8S caveolin complex interacts with lipid membranes through a novel leaflet replacement mechanism, revealing its role in membrane curvature and organization.

Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domain

The paper develops nanobodies that bind Cavin1's HR1 domain, revealing structural flexibility and regulated interactions important for caveolae assembly.

Lipid packing contributes to the confinement of caveolae to the plasma membrane

This study shows that lipid packing, particularly cholesterol, influences caveolae stability and dynamics in the plasma membrane.

Lipid Organization by the Caveolin-1 Complex

This study uses molecular dynamics simulations to show how the CAV1-8S complex bends membranes and extracts cholesterol, revealing limitations of the Martini v2 forcefield.

Role of Caveolin 1 in metabolic programming of fetal brain

This study investigates how the absence of Caveolin-1 in fetal brain affects metabolism, epigenetics, and aging in mice by integrating metabolomics, transcriptomics, and single-cell data.

Loss of Caveolin-1 and caveolae leads to increased cardiac cell stiffness and functional decline of the adult zebrafish heart

This study shows that loss of Caveolin-1 in zebrafish leads to increased cardiac cell stiffness and impaired heart function, but allows for heart regeneration after injury.