Caveolin-1 and cellular processes

The Actin Cytoskeleton and Caveolae Regulate MERTK Cleavage by ADAM17.

The paper shows that MERTK and ADAM17 are localized to distinct membrane microdomains, and MERTK cleavage by ADAM17 occurs only after reorganization of the actin cytoskeleton to bring them together.

Low-dose doxorubicin drives caveolin-1 depended re-epithelialization of breast cancer cells as a mechanism of cancer plasticity

This study shows low-dose doxorubicin induces caveolin-1-dependent re-epithelialization in breast cancer cells, altering membrane organization, epithelial phenotype, and autophagy.

Atomistic Insights into TRPC6/Caveolin-1 Interactions Interface via All- Atom Molecular Dynamics Simulations: Structural and Energetic Basis for Selective Modulation

This study uses molecular dynamics simulations to characterize the TRPC6-CAV1 interaction, revealing an acidic patch in TRPC6 and a basic segment in CAV1 that form a cooperative binding interface with favorable binding free energy.

Membrane Curvature Generation by the Caveolin 8S Complex and the Role of Cholesterol

This study shows the 8S caveolin complex generates positive membrane curvature through a conical shape, with cholesterol affecting curvature via stress relief rather than direct binding.

Structures of EHD2 filaments on curved membranes provide a model for caveolar neck stabilization

This study uses cryo-electron tomography to reveal the structure of EHD2 filaments on curved membranes, showing how they stabilize caveolar necks and their role in cellular dynamics.

Membrane Remodeling by the Collective Action of Caveolin-1

This study develops a coarse-grained model to investigate how caveolin-1 proteins drive membrane curvature through collective interactions.

Loss of either RASSF1A alone or in combination with Caveolin-1 inhibition is associated with different premalignant histopathological alterations in the mammary glands of transgenic mice

The paper investigates the effects of RASSF1A and Caveolin-1 loss on mammary gland histopathology in mice, finding distinct premalignant changes with single or combined gene inactivation.

Remote Control of Cell Signaling through Caveolae Mechanics

The paper investigates how mechanical stress affects caveolae mechanics, leading to the release of caveolin-1 scaffolds and modulation of signaling pathways like JAK1, eNOS, PTEN, and PTP1B.

CLIC-dependent internalization of caveolin-1 to lysosomal vacuoles in response to osmotic regulation

The paper shows that caveolin-1 is internalized via CLIC-dependent endocytosis to lysosomal vacuoles in response to osmotic changes, defining a new recycling pathway for membrane buffering.

Orai1 is required for Ca2+-dependent plasma membrane repair and mechanoadaptation

This study identifies Orai1 and EHD2 as essential for Ca2+-dependent plasma membrane repair and mechanoadaptation in response to mechanical injury and bacterial toxins.

Cardiomyocyte caveolae govern myocardial function and sex-dependent regulation of ventricular compliance and resilience via cavin-1

This study investigates the role of cardiomyocyte caveolae and cavin-1 in myocardial function, revealing sex-dependent effects on ventricular compliance and resilience through mechanisms involving NOS signaling and fibrosis.

PRINCIPLES GOVERNING ENDOTHELIAL CAVEOLAE ORGANIZATION DURING ANGIOGENESIS

This study investigates how caveolae are spatially organized in endothelial cells during angiogenesis and identifies their predictive role in vascular stability.

Mechano-sensitivity of multi-component caveolae

This paper presents a thermodynamic model showing how caveolae release components under tension, with EHD2 rings enabling a switch-like response to tension variations.

Structural basis of caveolin-driven membrane bending

This study identifies how caveolin-1's hydrophobic residue patterning drives membrane bending through structural and computational analyses.

BIN1 overexpression rescues cardiac but not skeletal muscle defects in a mouse model of caveolinopathy

This study shows BIN1 overexpression improves cardiac but not skeletal muscle function in Cav-3 knockout mice, highlighting tissue-specific therapeutic responses in caveolinopathies.

Membrane contacts between caveolae and the endoplasmic reticulum regulate uptake and metabolic trapping of long-chain fatty acids

The paper investigates how caveolae and ER membrane contacts regulate LCFA uptake and metabolic trapping, showing FATP1 and caveolin1's role in coupling these processes.

Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth

This study shows that dietary lipids induce caveolae uptake, caveolin1 accumulation to lipid droplets, and caveolin1-dependent lipid droplet growth.

Microprotein miP-PSTPIP2 affects cytoskeleton dynamics to modulate endothelial cell endocytosis, barrier function and migration

This study identifies miP-PSTPIP2, an inflammation-induced microprotein that modulates endothelial cell endocytosis, cytoskeleton dynamics, and barrier function by affecting Arp2/3-mediated actin dynamics.

Activated protein C promotes beta-arrestin-2- and c-Src-dependent caveolin-1 (Cav1) phosphorylation and alters Cav1 association with PAR1 and GRK5

This study shows APC activates PAR1 through βarr2 and c-Src to phosphorylate Cav1 and alter its interactions with PAR1 and GRK5 in endothelial cells.

Proline 110 is necessary for maintaining a compact helical arrangement in caveolin-1

The paper investigates the structural role of Proline 110 in caveolin-1 by analyzing conformational changes using FRET and static light scattering.

Mechanism of membrane curvature generation and caveola formation by flat disc-like complexes of caveolin

This study proposes a mechanism by which caveolin discs generate membrane curvature and caveola formation through lipid monolayer interactions and elastic stresses.

Palmitoylated caveolin-1 enables endosome sorting of complex sphingolipids

The paper shows that palmitoylated caveolin-1 facilitates endosome sorting of complex sphingolipids to the plasma membrane, independent of caveolae.

Seipin Regulates Caveolin-1 Trafficking and Organelle Crosstalk

This study shows that seipin regulates CAV1 trafficking and organelle interactions by controlling lipid metabolism and membrane order, impacting cellular homeostasis and metabolic disorders.

Mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signaling in Caveolin-1 null mice

This study investigates how the absence of Caveolin-1 affects mammary gland metabolism and its impact on fetoplacental cytokine signaling through integrative metabolomics and transcriptomics analyses.

Seeking the Membrane-Bound Structure of the Caveolin 8S Complex

This study validates the scaffolding mechanism of the 8S complex in generating membrane curvature through all-atom simulations, showing it adopts a conical shape with lipid interactions.

Interhelical distance measurements support a hairpin conformation for Caveolin-1 in phospholipid bicelles

The paper uses FRET and MD simulations to determine the conformation of Cav1 intramembrane helices in bicelles, supporting a hairpin structure.

Unsaturated lipids as key control points for caveola formation and disassembly

This study identifies specific unsaturated lipids as critical for caveola formation and their disassembly under oxidative stress.

Caveolin assemblies displace one bilayer leaflet to organize and bend membranes

This paper investigates how the CAV1-8S caveolin complex interacts with lipid membranes through a novel leaflet replacement mechanism, revealing its role in membrane curvature and organization.

Reducing the CAV1-dependent trafficking of G6PC1 in the liver protects against the development of type 2 diabetes

This study shows that reducing CAV1 in the liver decreases glucose production and improves metabolic parameters in diabetic mice.

Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domain

The paper develops nanobodies that bind Cavin1's HR1 domain, revealing structural flexibility and regulated interactions important for caveolae assembly.