C. Yan

Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

The paper presents a high-resolution cryo-EM structure of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing new structural features and interactions.

MicroRNA-574 Regulates FAM210A Expression and Influences Pathological Cardiac Remodeling

This study identifies miR-574 as a regulator of FAM210A, which influences mitochondrial protein expression and cardiac remodeling in heart failure.

Cryo-EM Structure of the Human Mitochondrial Translocase TIM22 Complex

The paper reports the cryo-EM structure of the human TIM22 complex at 3.7 angstrom resolution, revealing its architecture and potential mechanism for protein import.

CsHscB as a novel TLR2 agonist from carcinogenic liver fluke Clonorchis sinensis modulates host immune response

The paper identifies CsHscB from Clonorchis sinensis as a TLR2 agonist that modulates macrophage activation and IL-10 production through TLR2-dependent mechanisms.

Sam50-Mic19-Mic60 axis Determines Mitochondrial Cristae Architecture by Mediating Mitochondrial Outer and Inner Membrane Contact

This study identifies the Sam50-Mic19-Mic60 axis as critical for mitochondrial cristae architecture by connecting SAM and MICOS complexes through OMA1-mediated cleavage of Mic19.

Raven Calls Indicate Sender’s Neural State

This paper uses a BPNN to classify emotional states in raven calls, identifying categories like alarm and singing.

The gut microbiota regulates mouse biliary regenerative responses

This study shows that gut microbiota influences biliary regenerative responses in mice, with butyrate playing a role in inhibiting fibrosis.

LonP1 Orchestrates UPRmt and UPRER and Mitochondrial Dynamics to Regulate Heart Function

This study shows LonP1 regulates UPRmt and UPRER, and mitochondrial dynamics in cardiomyocytes, impacting heart function and revealing potential therapeutic targets for heart failure.

Structures of the Human Spliceosomes Before and After Release of the Ligated Exon

This study reports cryo-EM structures of two late-stage human spliceosomes, revealing insights into exon release and spliceosome disassembly mechanisms.

Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching

The paper determines cryo-EM structures of yeast spliceosome B* complexes to elucidate the mechanism of the branching reaction during pre-mRNA splicing.

Microtubule acetylation is required for mechanosensation in Drosophila

This study shows that microtubule acetylation via dTAT is essential for mechanosensation in Drosophila, affecting touch, gravity, and sound responses but not thermal sensing.