G. Li

Engineered dendritic cells expressing checkpoint receptor ligands reduce insulitis and hyperglycemia in NOD mice by enhancing regulatory T cell responses and suppressing effector T cell function.

This study shows that Bacillus velezensis SQR9 uses a type VII secretion system to acquire iron from plant roots, enhancing its colonization.

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

The paper identifies TGF-β-dependent differentiation of stem-like CD8+ T cells into tissue-resident memory T cells in tumor draining lymph nodes, which negatively correlates with tumor vaccine response.

This study shows that complete depletion of linker histone H1 in Arabidopsis disrupts correlations between chromatin compartmentalization, DNA methylation, and gene expression.

This paper develops FLT4-targeted nanocarriers for glaucoma therapy, showing improved IOP reduction and targeted delivery to Schlemms canal cells.

This study shows that time-scales influence the optimal lysis-lysogeny decisions of phages, with plastic responses enhancing near-term fitness and being robust to cellular stochasticity.

This study shows that non-neutralizing antibodies targeting HIV-1 envelope regions reduce mucosal infection and virus burden in humanized mice through Fc-mediated effector functions.

This study shows that genetic inhibition of SGK1 reduces obesity-related atrial fibrillation in mice by decreasing fibrosis, inflammation, and altering electrophysiology.

This study shows that Gastrin-producing mesenchymal stem cells protect NOD mice from type 1 diabetes by preserving beta-cell mass and modulating immune responses.

This study investigates how Trichoderma reesei senses glucose and regulates enzyme production and development in response to plant environments.

The paper shows that loss of plasma membrane lipid asymmetry can induce ordered domain formation in PMVs, suggesting dynamic asymmetry control regulates raft stability.

The paper investigates embryo-endosperm signaling in rice using a mutant to identify regulatory pathways affecting endosperm development and proposes a new staging system for rice seed development.

This study identifies a two-component system in UPEC that enhances bacterial survival under oxidative stress and promotes host cell pyroptosis via hemolysin.

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

This study compares the metabolic profiles of sweet potato leaves grown in soil versus hydroponic systems to identify metabolites associated with taste quality differences.

This paper introduces a deep learning method to improve light-field microscopy, enabling high-speed, artifact-free volumetric imaging of biological processes.

This study identifies novel regulatory modules involving ZmBEH1 and ZmBZR1 that control leaf angle in maize, offering new gene editing targets for improving plant architecture.

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

This paper introduces a rapid method for sample partitioning into microwells for digital bioassays, achieving high-density arrays with over 100,000 wells in under 30 seconds.

This study identifies prognostic non-tumor cell types in glioblastoma by analyzing gene expression across four cohorts, revealing risk and protective factors associated with immune response clusters.

This paper develops a chip-based system combining microfluidics and light-field microscopy with deep learning to high-speed 4D image and analyze moving C. elegans.

This study combines enhanced biological phosphorus removal with nitrite accumulation in a reactor treating synthetic digested manure wastewater, achieving high phosphorus removal and stable nitrite levels.

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.

This study identifies FAM72A as a regulator of mutagenic uracil repair during antibody maturation by antagonizing UNG2 activity.

This study examines microbial community distribution in oil-production reservoirs, finding that environmental variation and diffusion-limited transfer shape distinct communities in different sections.

This study shows that loss of Tmem30a in podocytes causes albuminuria and glomerulosclerosis in mice, with reduced TMEM30A expression observed in human podocytopathies.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.