G. Yu

Scaling between stomatal size and density in forest plants

The paper tests hypotheses about stomatal size-density scaling in plants using macroevolutionary models and phylogenetic regression on 2408 species, finding support for the stomatal-area increase hypothesis for higher gmax.

Bistable host-pathogen interaction explains varied infection outcomes

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

New metabolic alterations and predictive marker pipecolic acid in sera for esophageal squamous cell carcinoma

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

Structure of SOQ1 lumenal domains identifies potential disulfide exchange for negative regulation of photoprotection, qH

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

Evolution of the bread wheat D-subgenome and enriching it with diversity from Aegilops tauschii

The paper sequences 242 Ae. tauschii accessions to study genetic diversity in the bread wheat D-subgenome, identifies disease resistance genes, and demonstrates their functional transfer into wheat.

Analysis of Spleen Histopathology, Splenocyte composition and Hematological Parameters in Mice Infected with Plasmodium berghei K173

This study examines splenomegaly, histopathology, and splenocyte composition in mice infected with Plasmodium berghei K173, showing strain-specific differences in parasite control and splenic function.

Prime editing enables precise genome editing in mouse liver and retina

This study demonstrates that prime editing can correct disease-causing mutations in adult mouse liver and retina, with minimal off-target effects.

Allantoin induces pruritus by activating MrgprD in chronic kidney disease

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 homeostasis and is targeted by a bacterial type-III effector

This study shows that the bacterial effector RipAC targets PUB4 to inhibit PTI by disrupting BIK1 homeostasis.

A bacterial effector uncovers a metabolic pathway involved in resistance to bacterial wilt disease

This study identifies a metabolic pathway involving pyruvate decarboxylases that contributes to plant resistance against bacterial wilt disease, and shows how a bacterial effector inhibits this pathway to promote disease.

Quantitative proteomics reveals the protective effects of ESD against osteoarthritis via attenuating inflammation and modulating immune response

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

Accurate recognition of colorectal cancer with semi-supervised deep learning on pathological images

This paper develops a semi-supervised deep learning model for colorectal cancer recognition using pathological images, showing it outperforms supervised learning with limited labeled data and matches pathologists' performance.

SGT1 is not required for bacterial PAMP-triggered immunity

This study shows that SGT1 is not required for bacterial PAMP-triggered immunity in Nicotiana benthamiana and Arabidopsis.

Accurate Diagnosis of Colorectal Cancer Based on Histopathology Images Using Artificial Intelligence

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

Global Screening of Sentrin-Specific Protease Family Substrates in SUMOylation

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

Perturbation of GABA Biosynthesis Links Cell Cycle to Control Arabidopsis thaliana Leaf Development

This paper investigates how perturbing GABA biosynthesis in Arabidopsis affects leaf development by linking it to endoreplication and cell expansion.

A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity

This study identifies RipAC, a bacterial effector that inhibits SGT1 phosphorylation by blocking its interaction with MAPKs, thereby suppressing plant immunity.

Intra-strain elicitation and suppression of plant immunity by Ralstonia solanacearum type-III effectors in Nicotiana benthamiana

This study investigates how Ralstonia solanacearum uses effector proteins to elicit and suppress plant immunity in Nicotiana benthamiana.

3D association of ER, PR and Her2 at protein levels to aid sub-grouping of breast cancer patients in routine clinical practice

This study uses Quantitative Dot Blot to measure protein levels of ER, PR, and Her2 in FFPE samples, enabling 3D subtyping of breast cancer patients for prognosis and prediction.

Developing a routine lab test for absolute quantification of Her2 in Formalin Fixed Paraffin Embedded (FFPE) breast cancer tissues using Quantitative Dot Blot (QDB) method

This paper develops and validates a Quantitative Dot Blot (QDB) method for absolute quantification of Her2 in FFPE breast cancer tissues, showing high correlation and diagnostic accuracy comparable to IHC and FISH.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airways

This paper identifies niclosamide and nitazoxanide as potent TMEM16A antagonists that fully bronchodilate airways, offering new treatment options for severe asthma and COPD.

Specificity of RNA folding and its association with evolutionarily adaptive mRNA secondary structure

The paper assesses RNA folding specificity in mRNA and noncoding RNA, finding that specific folding is more evolutionarily adaptive and functionally significant.

Experimental Zika Virus Infection in a New World Monkey Model Reproduces Key Features of the Human Disease

This study infects marmosets with Zika virus and finds they exhibit key features of human disease, including asymptomatic infection and viral persistence in lymph nodes.

Predicting drug resistance evolution: insights from antimicrobial peptides and antibiotics

The paper predicts that resistance evolution is less likely against antimicrobial peptides compared to antibiotics due to their pharmacodynamic differences, offering a framework for antibiotic stewardship.