J. Luo

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

The paper shows male NSCLC cells produce more serine from glucose and are more sensitive to pemetrexed than female cells, suggesting sex differences in antifolate response.

This study identifies a core salivary microbiome across human populations using 16S rRNA sequencing, showing stability and variability influenced by geographic location and diet.

The paper models current and future distributions of bat hosts of sarbecoviruses, identifying hotspots and projecting range contractions under climate change scenarios.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study identifies a phosphoregulated RhoGEF2 feedback loop that tunes cortical flow and migration in Drosophila primordial germ cells during in vivo homing.

This study shows that oral administration of BefA from E. coli reduces blood glucose and improves beta cell function in both T1DM and T2DM mice.

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

The paper identifies sex differences in glutamine metabolism in glioblastomas, showing male tumors have higher glutamine uptake and are more sensitive to GLS1 inhibition than female tumors.

This paper develops a method to identify beneficial mutations in evolved microbial strains and applies it to improve ferulate tolerance in Acinetobacter baylyi ADP1.

This study identifies Lem8, a protease effector from Legionella pneumophila, which inhibits host cell motility by targeting Phldb2 via 14-3-3ζ-dependent activation.

This study shows spermidine directly inhibits Th17 cytokine production via PRDX1-dependent antioxidant activity, reducing lung inflammation in mouse models.

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

This study characterizes clinical and molecular features of acquired resistance to PD-(L)1 blockade in NSCLC, identifying persistent inflammation and dysfunctional IFN signaling as key features.

The paper investigates haemosporidian infections in nestling birds of prey in Mongolia, finding 10% infection rate with Plasmodium and highlighting high species richness.

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

This study identifies a two-component system in UPEC that enhances bacterial survival under oxidative stress and promotes host cell pyroptosis via hemolysin.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

This study shows that EGCG from green tea inhibits SARS-CoV-2 and its variants by blocking spike protein binding to ACE2 receptors.

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

The paper describes a new fungal genus and species from root-associated environments, proposes a new family based on phylogenetic and phenotypic data, and highlights limitations of sequence-only analyses.

This study shows that high-dose sodium butyrate causes reversible metabolic paralysis by inducing transient mitochondrial reprogramming in the brain, specifically through ANT protein activation and proton leak.

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

The paper identifies ARID1A deficiency's role in promoting pancreatic tumorigenesis by reducing KRAS-induced senescence through upregulation of ALDH1A1 in mouse PanIN models.

This study investigates how light intensity affects the coloration and structure of chimeric leaves in Ananas comosus var. bracteatus, finding that 50% shade optimizes growth and ornamental value.

The paper investigates photosynthesis-related gene expression in albino Artocarpus heterophyllus seedlings, finding down-regulated genes in pigment synthesis and photosynthesis pathways.

This study examines how astrocytes respond genetically to ultrasound-induced cavitation by analyzing gene expression changes over 48 hours post-exposure.

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.