L. He

This study identifies METTL3's role in promoting homologous recombination repair and modulating chemotherapeutic response in breast cancer cells by regulating the EGF/RAD51 axis through m6A modification.

The paper develops Bmi-1/hTERT cell lines to model CFTR variants and shows that CC-90009 partially rescues W1282X-CFTR function while affecting sodium channel activity.

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

The paper identifies a novel endothelial cell population in tumors that contributes to vascularization and growth.

This study identifies genomic differentiation in Helicobacter pylori across East Asia, linking specific SNPs to cancer risk and geographic adaptation.

This paper introduces SMAC, a single-molecule imaging technique that detects disease-specific proteins in blood samples at subfemtomolar concentrations.

A nanoparticle vaccine candidate induces broadly neutralizing antibodies against multiple SARS-CoV-2 variants through enhanced immune responses.

The paper develops a 2-step formate-reduction pathway by screening and engineering enzymes, but finds no in vivo biomass assimilation despite in vitro activity.

This study isolates HIV-1 neutralizing antibodies from mice and rabbits immunized with gp41-stabilized trimers and nanoparticles, showing they target different epitopes and elicit Env-dependent breadth.

The paper investigates ACE2 expression and SARS-CoV-2 infection in human endothelial cells, finding low or absent ACE2 expression and no viral replication.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

This study shows DNAJB12 and Hsp70 facilitate conformation-specific degradation of N1303K-CFTR intermediates via ERQC-autophagy, distinct from ERAD.

This study uses cryo-EM to determine the structure of the TSCC complex, revealing its architecture and potential mechanisms of Rheb regulation.

The paper develops SARS-CoV-2 vaccine candidates by displaying the receptor-binding domain and a stabilized spike on self-assembling protein nanoparticles, showing enhanced neutralizing antibody and T-cell responses.

This study shows that miR-200 deficiency in lung cancer cells promotes metastasis by activating cancer-associated fibroblasts through Notch signaling.

This study identifies Dhx36 as essential for skeletal muscle stem cell regeneration by regulating mRNA translation through binding and unwinding 5' UTR G-quadruplex structures.

This study designs and tests Ebola virus vaccines using stabilized GP trimers displayed on nanoparticles, showing they induce neutralizing antibodies and enhance infection.

This study identifies Alectinib as an FDA-approved drug that inhibits SARS-CoV-2 nucleocapsid phosphorylation and viral replication in vitro by targeting host kinases.

This study shows chronic palmitic acid exposure reduces AKT in beta-cells via mTOR activation, leading to cell cycle inhibition and T2D risk.

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

This paper evaluates a randomized basket trial design that controls false positive rate by indication, showing improved efficiency compared to parallel studies.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This paper introduces hydrazine-based chemoproteomic probes to target cofactor-dependent enzymes, enabling enzyme discovery and drug development through diverse functional profiling.

The paper uses glycopeptidomics to analyze host cell lines and identify specific glycopeptides associated with gastric MALT lymphoma, offering potential markers for early diagnosis.

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

The paper shows that pericytes, not endothelial cells, express ACE2 in microvessels, suggesting they may be infected in COVID-19 and contribute to microvascular inflammation and hypercoagulopathy.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

This study shows that reducing TNFR2 signaling in mice increases breast cancer incidence and aggressiveness, suggesting TNFR2 agonists could help prevent breast cancer in high-risk populations.

The paper shows that the TYLCV protein V2 suppresses viral genome methylation in plant Cajal bodies by interacting with AGO4.