L. Wang

This study shows that deep learning-based contact map predictions can capture structural information of multiple states, enabling exploration of alternative conformations of a known protein structure.

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

This study shows that transposable element invasion in Drosophila melanogaster leads to molecular adaptation through recurrent insertions into a specific lncRNA under positive selection.

The paper maps the localization of 1,032 chloroplast proteins in Chlamydomonas reinhardtii, revealing novel structures, spatial organization, and dual-organelle targeting.

This study examines the association between salivary and nasopharyngeal microbiomes and SARS-CoV-2 infection severity, finding specific bacterial taxa linked to disease outcomes.

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

The paper develops chemical labeling strategies to tag lipid-modified RNAs and identify new regulatory enzymes involved in prenylation.

The paper identifies a 17-gene signature from post-NAC biopsies that shows downregulation of immune and pathway genes associated with TNBC recurrence.

This study identifies distinct gut microbiome signatures in adult atopic dermatitis patients compared to healthy individuals in southern China.

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

This study shows VASP forms liquid-like droplets that drive actin polymerization and bundling by creating actin-rich rings that transition into linear bundles.

This paper develops a microfluidic chemostatic bioreactor for high-throughput screening of microalgal growth and lipid production, achieving higher throughput and efficiency compared to traditional methods.

The paper develops a microfluidic droplet array for high-throughput screening of lipid-producing microalgae, enabling real-time monitoring and identification of individual cells under different conditions.

This study shows that MEK inhibition sensitizes fusion-negative rhabdomyosarcoma to ionizing radiation via SNAI2 downregulation, leading to increased apoptosis and tumor regression.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This study evaluates a multivalent mRNA vaccine encoding SARS-CoV-2 and SARS-CoV receptor-binding domains, showing it induces cross-neutralizing antibodies against multiple variants in mice.

This study identifies a viral export signal in hepatitis A virus that requires dual recruitment of HD-PTP and ALIX for nonlytic release in extracellular vesicles.

This paper introduces a high-resolution line-scan Brillouin microscope for live-imaging mechanical properties during embryo development with reduced photo-toxicity.

This study shows G6PD inhibition increases oxidative stress and reduces omental metastases in ovarian cancer.

This paper introduces Wolffia australiana as a model system for studying plant morphogenesis using a Plant-on-Chip culture system and advanced technologies like snRNA-seq.

This study shows DMT1 modulates mitochondrial iron translocation in invasive breast cancer cells by bridging endosomes and mitochondria, affecting iron levels and mitochondrial function.

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

The paper designs long-acting GLP-1 receptor agonists using structural biology to prevent DPP-4 degradation while maintaining receptor binding, achieving hypoglycemic effects lasting over 24 hours.

This study shows that separating kinase and phosphatase activities in the Bub complex is essential for proper mitosis, as merging these functions leads to mitotic defects.

The paper identifies potent YB-1 inhibitors using an integrative approach combining microtubule bench assay, NMR, and MD simulations.

A genetic screen in Arabidopsis identifies DDRM2, a multi-BRCT domain protein required for homologous recombination and regulated by SOG1.

This study identifies RipAF1 as an effector that ADP-ribosylates host FBN1, inducing resistance against bacterial wilt by disrupting disease signaling.

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

The paper examines antibody responses to SARS-CoV-2 variants, finding convergent epitope specificities, V gene usage, and public B cell clones across different variants.