L. Wang

This study measures steric pressure generated by intrinsically disordered domains of AP180 at membrane surfaces, finding that they produce significant pressure through entropic and electrostatic mechanisms, independent of molecular weight.

This paper demonstrates the synergistic potential of niraparib and doxorubicin in ovarian cancer treatment and develops folate receptor-targeted nanoparticles for their delivery.

This study compares alignment-free k-mer hash and ASV methods for classifying fresh produce safety and quality using microbiome data, finding higher accuracy with k-mer hashes.

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

This study identifies a common binding site for diverse Sec61 inhibitors and shows how they stabilize the plug domain to block protein translocation.

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

This study identifies endothelial mitophagy as a source of mitochondrial formyl proteins that activate neutrophils and contribute to lung inflammation.

This study compares the pathogenicity of SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.5, finding BA.5 is more fusogenic and induces stronger inflammation than earlier variants.

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

This paper develops multispecific antibodies that neutralize all SARS-CoV-2 variants, including Omicron, by targeting multiple epitopes on the spike protein.

This paper introduces a method to modulate aptamer affinity using a molecular clamp that destabilizes secondary structure through mechanical tension, demonstrating up to 65-fold affinity changes without prior structural knowledge.

This study identifies cervical epithelial subtypes in mice during pregnancy and labor using single-cell transcriptomics and spatial analysis, revealing how barrier dysfunction contributes to preterm birth risk.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

This study maps the global distribution of antibiotic resistance genes in soils and identifies key environmental drivers influencing their prevalence.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

REST is a deep learning method that restores cryo-ET density maps by denoising and compensating for missing wedge effects, enabling visualization of individual macromolecules.

This study uses a tissue-engineered human dermal microvessel model to investigate Borrelia burgdorferi invasion and intravasation, finding no adhesin-mediated interactions and showing Bb-induced endothelium activation.

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

The paper introduces a method to detect and analyze i6A-modified RNA with single-base resolution using iodine-mediated oxidation and reverse transcription.

This paper identifies BysR as a LysR-type regulator that activates ambR1 to control occidiofungin production in Burkholderia sp. JP2-270 and reveals its broader regulatory role in metabolism and motility.

This study investigates how binding partners regulate myosin VI unfolding and activation through biochemical and single-molecule analyses of splice isoforms.

This study generates genetically engineered goats expressing a domain fusion TLR2-4 receptor to enhance autophagy-dependent clearance of Staphylococcus aureus in macrophages.

The paper shows that aging-related iron accumulation reduces estrogen receptor expression, diminishing the benefits of hormone replacement therapy in late postmenopausal women with atherosclerosis.

This paper investigates retinal energy metabolism, revealing that photoreceptors use distinct metabolic pathways, including the mini-Krebs, Cahill, and Cori cycles, to uncouple glycolysis from oxidative phosphorylation.

The paper was withdrawn due to poor experimental design and irreproducible results.

This study shows that skeletal muscle is not required for limb regeneration in axolotls, as Pax7 mutants regenerate limbs with normal patterns and cell composition.

This paper identifies SidI, a Legionella toxin that mimics tRNA, glycosylates the translation machinery, and triggers a ribotoxic stress response leading to cell death.

This study introduces a metallo-supramolecular branched polymer to improve particle distribution in single-particle cryo-EM by preventing air-water interface damage and preferred orientation.