M. Wang

This study identifies widespread arginine phosphorylation in human cells using a novel phosphoproteomic workflow, revealing 152 high-confidence sites across 118 proteins.

This study analyzes RNA editing in cephalopods, identifying genes with high diversity from editing and showing distinct amino acid substitution patterns that suggest adaptive selection.

This study identifies DDAs as compounds that upregulate DR5 in cancer cells, leading to apoptosis and synergy with TRAIL, with selectivity for oncogene-transformed cells.

This study identifies ANP32A and ANP32B as essential for influenza A virus polymerase activity, showing species-specific roles and mutations affecting viral replication.

This paper reports a 1.6 Å crystal structure of the GTPase domain of LRRK2, revealing how PD-associated mutations at Arg-1441 impair nucleotide-dependent conformational dynamics.

The paper generates 3D maps of microbiomes and metabolomes in cystic fibrosis lungs, revealing personalized and regiospecific chemical environments and microbial interactions.

The paper challenges the Recent Out of Africa model by proposing multiregional evolution of autosomes and East Asian origin of modern Y and mtDNA through hybridization with archaic humans.

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

The paper identifies novel conjugated bile acids produced by the microbiome in mice and humans using mass spectrometry and a murine 3D model.

MolNetEnhancer integrates metabolomics tools to improve chemical annotation and structural insight from mass spectrometry data.

The paper presents a MALDI-TOF MS method to detect ovarian cancer progression using vaginal fluid samples from tumor-bearing mice.

The paper finds that conservative amino acid changes are more common in fixed and standing missense variations of slow evolving proteins, suggesting these variations are more neutral and suitable for phylogenetic inferences.

The paper uses serial synchrotron crystallography to capture the proton uptake mechanism in bacteriorhodopsin over time, revealing structural changes associated with proton release and the formation of a proton wire.

The paper uses shotgun metagenomics to analyze the gut microbiome in AS patients, finding enriched bacterial epitopes linked to HLA-B27 and effects of TNFi therapy and host genotype on microbiome composition.

This study identifies novel and validated QTLs for fiber quality traits in Upland cotton using a paternal backcross population and RILs, with some QTLs explaining over 10% of phenotypic variation.

This study identifies surface proteins of Lactobacillus pentosus HC-2 as essential for its probiotic effects in shrimp midgut using proteomic analysis.

The paper measures metabolic rates and growth in Fagus crenata seedlings to show roots develop more rapidly and efficiently than other organs, supporting seedling survival.

The paper investigates the effectiveness of microbial coalbed methane enhancement in the Qinshui Basin, showing increased methane production through biogasification in specific wells.

This study designs a universal primer set for CAOB amoA genes and reveals their ubiquity and high abundance across diverse ecosystems.

This study characterizes the viral community of the South Scotia Ridge using metagenomic analysis, revealing novel viral sequences and high diversity.

This study uses Bayesian tip dating to analyze morphological evolution in Mesozoic birds, finding heterogeneous evolutionary rates across body regions.

This paper presents the X-ray structure of GtACR1, revealing a novel mechanism for anion conductance involving the Schiff base and tunnel architecture.

This study shows Bclaf1 is degraded by alphaherpesvirus US3 and is critical for type I interferon signaling and antiviral immunity.

This study identifies SP1 as a target of artificial selection in silkworms that enhances egg hatchability by improving nitrogen utilization and biosynthesis pathways.

This paper demonstrates phase imaging as a label-free method to detect optogenetic-induced intracellular transport in neurons.

This study evaluates how different pretreatments affect flavonoid content and antioxidant activity in Dryopteris erythrosora leaves, finding that shade drying followed by oven drying best preserves these properties.

This study identifies dimer-dependent catalytic activity in RAF family kinases through analysis of oncogenic mutants, revealing differential inhibitor resistance and MEK phosphorylation mechanisms.

This study shows that T7 helicase can restart DNA replication from an RNA transcript without replication restart proteins or primase.

This paper demonstrates a novel gene inactivation method using NHEJ-mediated mono-homologous linear DNA recombination in Dietzia sp. DQ12-45-1b, showing its potential for broad application in prokaryotes.