Z. Wang

The paper maps mutations in SARS-CoV-2 spike RBD that escape binding by three antibody classes and finds that plasma escape maps closely resemble those of a single antibody class targeting site E484.

This study develops a model of diauxic microbial communities and finds that complementary resource preferences emerge spontaneously during community assembly.

This study examines how somatic mutations in SARS-CoV-2 antibodies affect their neutralization potency, breadth, and resistance to escape mutations across six antibody lineages.

This study identifies molecular components contributing to the lens extracellular diffusion barrier through proteomic analysis of bovine lens cortex regions.

This study uses computational fluid dynamics to model microvascular changes in zebrafish tail regeneration, showing dynamic shifts in wall shear stress and flow rate during vascular remodeling.

This paper shows that anakinra, an IL-1 receptor antagonist, reduces fat browning and muscle wasting in Ctns-/- mice, suggesting it could treat cachexia in infantile nephropathic cystinosis.

This study shows that blocking IL-1 receptor reduces adipose browning and muscle wasting in CKD-associated cachexia in mice.

Under constant infection by Sclerotinia sclerotiorum, BnaA03.WRKY28 interacts with BnaA09.VQ12 and takes precedence over phosphorylated BnWRKY33 to bind to the BnWRKY33 promoter, thereby weakening resistance but promoting branching.

The paper identifies dominant cytotoxic T lymphocyte epitopes of Marek's disease virus, confirms their immunoprotective effects, and highlights key factors for effective antitumor immunity.

This study identifies a novel bone marrow-specific adipogenesis pathway that contributes to age- and disease-related expansion of bone marrow adipocytes with altered lipid storage and endocrine function.

This paper introduces Monoqlo, a deep learning workflow that automatically detects colony presence and identifies clonality from cellular imaging, enabling scalable and standardized monoclonalization.

BART Cancer identifies transcriptional regulators in 15 cancer types by integrating RNA-seq and ChIP-seq data to predict regulator activities.

The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.

This study evaluates the mechanical efficiency of an ankle-assisted robot during walking with varying loads, finding that efficiency decreases as device weight increases.

The paper traces the evolutionary origin of an enhancer that drives specific gene expression in Drosophila, showing that repressor sequences evolved before activator regions.

The paper profiles human fetal liver hematopoietic stem cells using multi-modal data to identify a molecular signature associated with engraftment potential.

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

This paper introduces a novel surgical method for continuous portal vein infusion of gut microbial metabolites in mice, demonstrating its effectiveness in altering plasma and hepatic metabolite levels and gene expression.

The paper develops a method to characterize soft materials using magnetic resonance imaging and data-driven modeling to infer their mechanical behavior.

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

This study shows that chromosomal instability accelerates cancer cell adaptation to anti-cancer therapies by enabling specific aneuploidy events that reduce drug sensitivity.

This study uses cryo-ET to reveal the molecular architecture of mouse skeletal sarcomeres, showing detailed interactions and conformational plasticity in actin and myosin filaments.

This study shows that secretory IgA, particularly dimers, are more potent than IgG in neutralizing SARS-CoV-2 in vitro, suggesting their importance for mucosal protection and vaccine design.

The paper develops deep learning models using RNA-seq data that incorporate isoform and exon information to improve smoking status prediction, achieving higher AUC than gene-level models.

This study combines light-field and light-sheet imaging to analyze myocardial biomechanics and intracardiac flow in zebrafish embryos, revealing decreased contractility from the AV canal to the outflow tract.

The paper shows pancreatic cancer cells use transglutaminase-2 to create CXCL12-keratin 19 coatings that block T cells and resist immunotherapy.

This paper reports a broadly neutralizing monoclonal antibody from a macaque infected with SHIVAD8 that targets the V3-glycan patch of HIV-1 Env, showing neutralizing activity and protective efficacy in vivo.

This paper develops a mouse model of prostatic inflammation and collagen accumulation using E. coli UTI89 instillations to study aberrant collagen production in the prostate.

The paper shows SARS-CoV-2 variants resistant to neutralizing antibodies can be selected and are present in circulating populations, suggesting the need for combination antibody therapies.

The paper identifies an evolutionary conserved NO-producing system in fungi, mammals, and plants, revealing multifunctional enzymes with implications for agriculture and medicine.