Steve Horvath

This paper develops epigenetic clocks for New Zealand livestock using DNA methylation data to predict chronological age accurately across multiple species.

This study develops an epigenetic clock for sheep and finds that castration slows aging and feminizes DNA methylation at androgen-regulated loci.

This paper develops epigenetic clocks for African and Asian elephants using DNA methylation data to estimate age and identify age-related CpGs and their associated genes.

The paper identifies an epigenetic signature in Cockayne syndrome fibroblasts, showing similarities to normal aging and differences from other progeroid diseases.

This study examines age-related DNA methylation changes in rat hippocampus and links them to spatial memory performance in young and old rats.

This paper develops epigenetic clocks for bovine oocytes and evaluates their ability to estimate chronological age and reveal differences in aging between oocytes and blood.

The paper identifies DNA repair hotspots in post-mitotic human neurons linked to genes essential for their identity and function.

This paper develops epigenetic clocks for dogs to estimate age and mortality risk, and identifies methylation sites linked to breed weight and lifespan.

The paper develops epigenetic clocks and pacemaker models to predict age in plains zebras and other equids using DNA methylation data from blood samples.

This study develops DNA methylation clocks for naked mole-rats and finds that queens age more slowly than non-breeders, suggesting a link between reproductive status and epigenetic aging.

This study uses DNA methylation profiles from bats to show that age and longevity are linked to specific methylation patterns, with longevity associated with immune and cancer-related genes.

The paper develops an epigenetic clock for beluga whales using DNA methylation data to estimate age and sex, achieving high accuracy in a conservation context.

This study develops pan-primate epigenetic clocks and sex predictors using DNA methylation data from 37 primate species, achieving high accuracy for age estimation across species.

The paper identifies age-related DNA methylation changes in human skeletal muscle through a meta-analysis and integrates these with transcriptomic and proteomic data, revealing enriched age-related gene expression patterns.

This study develops DNA methylation-based age estimators for prairie voles and finds that pair bonding slows epigenetic aging and alters methylation in brain tissue.

This study shows that DNAm GrimAge predicts disease incidence and prevalence better than other epigenetic clocks in a large cohort.

This study develops epigenetic clocks for rat and human tissues and shows that young plasma treatment reduces epigenetic age in multiple tissues and improves organ function.

The paper assesses four epigenetic clocks' associations with health, cognition, and mortality in the TILDA cohort, finding GrimAge provides better predictive utility for age-related decline.

The paper develops a muscle-specific epigenetic clock using DNA methylation data from skeletal muscle samples, achieving higher accuracy than a pan-tissue clock.

This paper introduces DNAm GrimAge, an epigenetic clock that predicts mortality and is associated with multiple brain health measures in older adults.

This paper conducts GWAS on two epigenetic age acceleration measures, identifying genetic variants and genes associated with each, and highlighting differences in their genetic architectures.

This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.

The paper analyzes DNA methylation changes across multiple tissues and cell types to show that a substantial portion of age-related methylation changes is shared between different cell/tissue types, with some sites showing age-related alterations in over 10 different types.

This study identifies genetic variants associated with epigenetic age acceleration and shows TERT's role in regulating the DNA methylation clock.

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.