Steven A. Carr

This paper presents an optimized workflow for high-throughput proteomic and phosphoproteomic analysis of FFPE tissues, achieving deep coverage and quantitative robustness comparable to TMT-based methods.

This study identifies CD45 as a sialic acid-dependent binding partner of CD33, showing that their interaction contributes to Alzheimer's disease susceptibility through impaired microglial function.

The paper identifies HDAC1/2 inhibition as a method to promote colorectal cancer differentiation through H3K27ac gains, which can be reversed by blocking EP300.

This study uses Massively Parallel Ribosome Profiling to identify thousands of viral ORFs, including non-canonical ones, and shows their impact on HLA-I peptides and protein synthesis regulation.

This study identifies AKAP11's role in regulating lipid metabolism and neuronal support in astrocytes, linking its dysfunction to schizophrenia and bipolar disorder risk.

This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.

This study identifies coagulation and immune factors secreted by Drosophila gut tumors that contribute to cachexia via NFκB and JNK pathways.

This study examines Gria3 mutant mice to identify transcriptomic and proteomic changes linked to schizophrenia, finding region-specific gene dysregulation and synaptic protein alterations.

This study uses multi-omics analyses of Sp4 mutant mice to reveal synapse disruption and age- and region-specific neuronal and glial changes linked to schizophrenia and bipolar disorder.

This study shows that SRRM2 haploinsufficiency in mice causes synaptic, splicing, and myelination defects linked to schizophrenia-like behaviors and gene expression changes.

This study identifies the intracellular signaling pathway of teneurins in synaptic partner matching using Drosophila models.

This study presents an automated single-cell proteomics workflow that identifies over 4,000 proteins per cell and detects key regulatory proteins in LPS-perturbed THP-1 cells.

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

The paper identifies NRXN3 as a neuron-specific marker for isolating extracellular vesicles from biofluids and develops methods to isolate these vesicles for neurological disease research.

This study identifies a 7-residue motif in unfolded proteins recognized by IRE1LD, revealing how IRE1 detects misfolded proteins to trigger the UPR.

SHIFTR identifies proteins bound to specific RNA regions in live cells with high accuracy and low input, enabling comprehensive RNA interactome mapping.

The paper identifies SARS-CoV-2 peptides presented by HLA-II complexes, showing their association with CD4+ T cell epitopes and distinct targeting of viral proteins compared to HLA-I.

The paper identifies Pp1-87B as a regulator of core PCP signaling by modulating Van Gogh subcellular localization and dephosphorylation in Drosophila wings.

This paper introduces LOV-Turbo, a light-regulated proximity labeling tool that enhances spatial and temporal control of proteomic mapping in living cells.

This study identifies brain region-specific changes and dopamine dysregulation in Grin2a mutant mice, supporting schizophrenia hypotheses and highlighting their utility as a genetic model.

This study identifies Acj6 as a transcription factor that controls dendrite targeting in Drosophila PNs by regulating combinatorial expression of cell-surface proteins.

This study shows that deleting GIT1 in the brain impairs cognition and disrupts phosphorylation networks of synaptic proteins linked to schizophrenia and neurodevelopmental disorders.

This study identifies bidirectional phosphorylation changes in Shank3 that regulate synaptic scaling up or down in mouse and rat neurons.

The paper identifies ADAMTS7 substrates and cleavage sites using TAILS, revealing potential biomarkers for coronary artery disease.

This study identifies KLHL40 as a negative regulator of ER-Golgi trafficking through ubiquitylation, revealing its role in skeletal muscle development and disease.

The paper introduces APEX-PS to map RNA binding proteins in cellular compartments, identifying SYNJ2BP as a mitochondrial mRNA anchor that aids stress recovery.

The paper introduces a cloud-based implementation of the AvG algorithm for DIA data analysis, improving efficiency and accessibility for large datasets.

PANOPLY is a cloud-based platform that automates and reproducibly analyzes proteogenomic data by integrating genomic, transcriptomic, proteomic, and post-translational modification data.