Dementia and Cognitive Impairment Research

Precuneus activity during retrieval is positively associated with amyloid burden in cognitively normal older APOE4 carriers

The paper examines how precuneus activity during memory retrieval relates to future amyloid burden and cognitive outcomes in APOE4 carriers and non-carriers.

Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer's disease

This study identifies molecular changes in white matter hyperintensities in Alzheimer's disease using transcriptomic analysis of brain regions and blood vessels.

Evaluating the association of APOE genotype and cognitive resilience in SuperAgers

This study examines the association between APOE genotype and cognitive resilience in SuperAgers, finding lower APOE-ε4 and higher APOE-ε2 frequencies in non-Hispanic White SuperAgers compared to controls and Alzheimer's cases.

Event-Related Potential Markers of Subjective Cognitive Decline and Mild Cognitive Impairment during a sustained visuo-attentive task

The paper identifies ERP biomarkers distinguishing subjective cognitive decline, MCI, and healthy controls during a sustained visual attention task, showing condition-specific dynamics and task performance correlations.

Reliability of structural brain change in cognitively healthy adult samples.

This study assesses the reliability of structural brain change in cognitively healthy adults over time, finding that longer follow-up periods significantly improve reliability compared to increasing observation frequency.

Factors behind poor cognitive outcome following a thalamic stroke

This study identifies cognitive profiles and factors influencing outcomes in patients with thalamic stroke using clustering and neuroimaging analyses.

Whole genome methylation sequencing in blood from persons with mild cognitive impairment and dementia due to Alzheimer's disease identifies cognitive status

The paper uses whole genome methylation sequencing in blood samples to identify differentially methylated positions associated with cognitive status in mild cognitive impairment and Alzheimer's disease.

Characterising ongoing brain aging and baseline effects from cross-sectional data

The paper disambiguates ongoing brain aging from baseline effects using cross-sectional data and validates findings with longitudinal data from UK Biobank.

Subregional Biomarkers in FDG PET for Alzheimer's Diagnosis and Staging: An Interpretable and Explainable model

The paper identifies key radiomic features from hippocampal and amygdala subregions in FDG-PET images to differentiate Alzheimer's Disease, MCI, and healthy controls with high accuracy.

Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers

The paper identifies subtypes of brain structural changes in aging and links them to cognitive decline and Alzheimer's disease biomarkers using MRI data.

APOE4 Increases Susceptibility to Amyloid, Accelerating Episodic Memory Decline

This study shows APOE4 carriers experience faster episodic memory decline linked to amyloid duration, with a dose-dependent effect in homozygotes, but not other cognitive domains.

Serotonin Enhances Neurogenesis Biomarkers, Hippocampal Volumes, and Cognitive Functions in Alzheimer's Disease

This study shows serotonin increases brain and hippocampal volumes and improves cognitive function in Alzheimer's disease by boosting neurotrophic factors and biomarkers linked to neurogenesis.

EXPLORING SOCIAL COGNITION DECLINE ACROSS ALZHEIMER'S DISEASE SEVERITY: INSIGHTS FROM A COMPARATIVE ANALYSIS

This study examines social cognition decline across Alzheimer's Disease stages, finding that Theory of Mind is a key link between social and nonsocial cognitive abilities, with executive functioning mediating SC impairment.

Longitudinal assessment of the conversion of mild cognitive impairment into Alzheimer's dementia: Observations and mechanisms from neuropsychological testing and electrophysiology

This study identifies biomarkers for predicting mild cognitive impairment conversion to Alzheimer's dementia using EEG, neuropsychological tests, and mathematical models.

Multimodal normative modeling in Alzheimer Disease with introspective variational autoencoders

This paper introduces a multimodal introspective VAE for Alzheimer's Disease normative modeling, improving reconstruction of healthy controls and outlier detection in neuroimaging data.

Connectivity in the human and the monkey brain probes causal involvement of the fornix in Mild Cognitive Impairment and Alzheimer's Disease

The paper investigates connectivity patterns in the human and monkey brain, identifying changes in fornix-related connections associated with Mild Cognitive Impairment and Alzheimer's Disease.

The urinary proteome of individuals with a family history of frontotemporal dementia (FTD) but without known mutations differs from that of healthy controls

This study compares urinary proteomes of FTD family members without mutations to healthy controls, identifying 428 differentially expressed proteins and 146 enriched pathways, including those related to neurons and Progranulin.

Examining heterogeneity in dementia using data-driven unsupervised clustering of cognitive profiles

This study uses unsupervised clustering on longitudinal cognitive data to identify subtypes of dementia, finding that mild dementia subtypes are more heterogeneous in progression.

Additive effects of cerebrovascular disease functional connectome phenotype and plasma p-tau181 on longitudinal neurodegeneration and cognitive outcomes

The paper examines how cerebrovascular disease markers and plasma p-tau181 interact to affect brain connectivity, grey matter volume, and cognitive decline over time.

Cognitive Reserve Against Alzheimer's Pathology Is Linked to Brain Activity During Memory Formation

The paper links cognitive reserve to brain activity during memory formation, showing it moderates the impact of Alzheimer's pathology on cognitive performance and predicts slower decline.

SMAS: Structural MRI-Based AD Score using Bayesian VAE

This paper introduces SMAS, a Bayesian VAE-based AD score from structural MRI data, showing strong correlations with cognitive decline and brain atrophy markers, and outperforming existing measures in predicting AD.

Resting-state connectivity modifies the effects of amyloid on cognitive and physical function: evidence for network-based cognitive reserve

The paper examines how resting-state brain networks modify the relationship between amyloid beta and cognitive/physical function in older adults, suggesting brain networks as a buffer against amyloid's negative effects.

Imaging synaptic density in ageing and Alzheimer's Disease with -SynVesT-1

This study uses [18F]-SynVesT-1 PET to analyze synaptic density in aging and Alzheimer's Disease, finding associations with amyloid-beta, tau, and cognitive performance.

A protective role for the cerebellum in cognitive aging

This study investigates the cerebellum's role in cognitive aging using large datasets, finding that cerebellar volume is associated with better cognitive outcomes and protection against decline.

The influence of birthweight, socioeconomic status, and adult health on brain volumes during aging

This study examines how birthweight, socioeconomic status, and adult health influence late-life brain volumes and dementia risk.

Regional associations of sleep architecture and Alzheimer's disease pathology

This study examines the relationship between sleep architecture and regional amyloid and tau pathology in individuals with MCI/AD and healthy controls.

Magnitude and Kinetics of a set of Neuroanatomic Volume and Thickness together with White Matter Hyperintensity is definitive of Cognitive Status and Brain Age

The paper uses neuroanatomic volumetry and white matter hyperintensity quantification with machine learning to estimate Brain Age and discriminate cognitive status in aging cohorts.

WIMOAD: Weighted Integration of Multi-Omics Data with Meta Learning for Alzheimer's Disease Diagnosis

WIMOAD integrates multi-omics data using a meta learning framework to improve Alzheimer's disease diagnosis by capturing complex patterns linked to clinical outcomes.

Mouse PAW: reverse-translating the FINGER multimodal lifestyle intervention enhances synaptic plasticity and cognition in adult wild type female mice

This study applies a multimodal lifestyle intervention in mice to improve cognition and synaptic plasticity, showing effects comparable to pharmacological interventions.

Elevated blood glucose levels are associated with the progression of brain hypometabolism, and HDL-C and APOE4 add to this association

This study finds that high blood glucose levels are associated with brain hypometabolism progression, with HDL-C and APOE4 further contributing to this association.