Dementia and Cognitive Impairment Research

Plasma pTau-217 Correlates with Brain Atrophy, Cognition, and CSF Biomarkers in a Cognitively Healthy Community Cohort

This study finds plasma pTau-217 correlates with cognition and brain atrophy in cognitively healthy older adults and strongly correlates with its CSF counterpart.

Periventricular Diffusivity Reflects APOE4-modulated Amyloid Accumulation and Cognitive Impairment in Alzheimers Continuum

This study shows that lower periventricular diffusivity is linked to higher amyloid-beta burden and cognitive decline, especially in APOE4 carriers.

Cognitive-and lifestyle-related microstructural variation in the ageing human hippocampus

This study identifies lifestyle factors associated with preserved hippocampal microstructure in younger adults, which correlates with better executive function but not memory.

Differential effects of neurodegenerative disorders on verbal creative idea generation and its cognitive cornerstones

This study examines how FTLD and AD differentially affect cognitive mechanisms underlying creative idea generation, finding distinct patterns in semantic retrieval, memory, and context-dependent creativity.

Telomere length and cognitive function among middle-aged and older participants from communities underrepresented in aging research: A preliminary study

This study examines the relationship between telomere length and cognitive function in underrepresented middle-aged and older adults, finding preliminary evidence of an independent association with chronological age.

Neurologically altered brain activity may not look like aged brain activity: Implications for brain-age modeling and biomarker strategies

This study shows that brain-age gaps from EEG spectral power in neurological populations do not reflect accelerated aging, challenging the use of EEG as a biomarker for neurodegeneration.

Repurposing drugs for the prevention of vascular dementia: Evidence from drug target Mendelian randomization

This paper uses Mendelian randomization to assess if existing drugs targeting lipid-lowering, anti-hypertensive, or anti-inflammatory pathways affect vascular dementia risk, finding potential benefits for beta-1 adrenergic receptor antagonists and risks for ACE inhibitors.

A Surface-based deep learning approach for cortical shape analysis

This paper applies a spherical harmonics-based deep learning model to MRI-derived brain shape metrics to predict age, sex, and Alzheimer's disease diagnosis, showing strong performance in classification and regression tasks.

Incorporating Multi-threshold Polygenic Risk in Hippocampal-based Normative Models Improves Cognitive Decline Prediction

The paper improves cognitive decline prediction by integrating multi-threshold polygenic scores into hippocampal-based normative models using UK Biobank data.

Analyzing heterogeneity in Alzheimer Disease using multimodal normative modeling on imaging-based ATN biomarkers

This study uses multimodal normative modeling on ATN biomarkers to analyze Alzheimer Disease heterogeneity, finding greater intra-group variation in more severe stages and a correlation between disease severity index and cognitive decline.

Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity

Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia

This study examines sex differences in clinical progression of autosomal dominant frontotemporal dementia, finding females show more rapid declines in symptomatic stages and less sensitive NfL prognostic value.

Synapse protein signatures in cerebrospinal fluid and plasma predict cognitive maintenance versus decline in Alzheimers disease

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

Non-linear and time-domain sleep qEEG features predict CSF protein damage markers in early Alzheimer's disease

The paper uses qEEG features from sleep stages to predict CSF oxidative biomarkers in early Alzheimer's disease with high accuracy.

Vulnerability to memory decline in aging. A mega-analysis of structural brain change.

This study investigates the relationship between brain atrophy and memory decline in aging using longitudinal data, finding a nonlinear association that intensifies with age and is influenced by APOE ε4 carriership.

Mapping Amyloid Networks in Alzheimer's Disease: A High-Order ICA Approach to Gray and White Matter Pathology

This study uses high-order ICA on PET scans to identify amyloid-beta networks in Alzheimer's Disease, revealing distinct gray and white matter patterns associated with cognitive impairment.

Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer's Dementia to Living Humans

This study translates post-mortem brain multi-omics AD dementia subtypes into blood, MRI, and psychological markers in living individuals.

Investigating Alzheimers Disease Biomarkers by Applying Machine Learning Models

This study uses machine learning to diagnose Alzheimer's Disease by analyzing biomarkers and clinical features, finding high accuracy with KNN, SVM, RF, and DT models.

Parsimonious EBM: generalising the event-based model of disease progression for simultaneous events

This paper introduces the parsimonious event-based model (P-EBM) to infer disease progression sequences with fewer stages than biomarkers, showing improved performance in Alzheimer's disease analysis.

Potential multiple disease progression pathways in female patients with Alzheimer's disease inferred from transcriptome and epigenome data of the dorsolateral prefrontal cortex

Lower GABA levels in the posterior cingulate are linked with poorer episodic memory in healthy older adults

Genetic dissection of hippocampal sclerosis of ageing using magnetic resonance imaging surrogates

The paper investigates the association between Alzheimer's disease SNPs and hippocampal sclerosis of aging using MRI surrogates in a cohort of non-demented individuals.

Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer's disease

The paper examines sex-specific and APOE4-related associations between cardiometabolic risk factors and white matter microstructure in individuals with a family history of Alzheimer's disease.

Alzheimer's disease-like features in resting state EEG/fMRI of cognitively intact and healthy middle-aged APOE/PICALM risk carriers

The paper examines EEG and fMRI data from middle-aged individuals with APOE/PICALM risk alleles to identify early Alzheimer's disease-like features before symptom onset.

APOE and TREM2 variants differentially influence glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants

This study examines how APOE and TREM2 variants influence plasma levels of GFAP and NEFL in UK Biobank participants, finding age-dependent effects and associations with dementia risk.

Multi-omic subtypes of Alzheimer's dementia are differentially associated with psychological traits

The paper examines associations between three multi-omic AD subtypes and four psychological traits, finding differential links between subtypes and traits.

Detecting Primary Progressive Aphasia (PPA) from Text: A Benchmarking Study

This study benchmarks machine learning models for classifying PPA subtypes from speech, finding that traditional classifiers with embeddings are competitive with transformer-based models.

Relationships of hematocrit concentration with dementia from a multiethnic population-based study

This study examines the association between hematocrit levels and dementia risk in a multiethnic cohort, finding that lower hematocrit is linked to increased dementia risk, with no mediation by cerebral small vessel disease.

Distinctive associations between plasma p-tau181 levels and hippocampal subfield volume across the Alzheimer's disease continuum

This study examines how plasma p-tau181 levels relate to hippocampal subfield volumes and cognitive function across Alzheimer's disease stages, finding specific associations with CA1 and dentate gyrus volumes.

Amyloid-β deposition in basal frontotemporal cortex is associated with selective disruption of temporal mnemonic discrimination

The paper investigates how amyloid-beta accumulation in specific brain regions relates to memory deficits in preclinical Alzheimer's disease, finding a selective impact on temporal memory.