Neurotransmitter Receptor Influence on Behavior

The paper identifies synaptic bioenergetic remodeling in the mPFC after heroin abstinence, but not cocaine, and links it to relapse vulnerability.

This study shows that KOR activation leads to DAT tolerance to cocaine via phosphorylation at threonine 53, demonstrated through behavioral, electrophysiological, and genetic experiments across species.

This study shows dopamine modulates striatal neuron activity to control movement by adjusting input-output efficacy in direct and indirect pathways.

This study shows that MCH signaling influences how reward-guided behavior persists or updates when contingencies change, with MCHR1 blockade reducing perseveration and speeding adaptation.

The paper investigates strain differences in extrinsic and intrinsic motivation tasks in mice, finding divergent motivational phenotypes across strains.

This study investigates sex-specific behavioral predictors of alcohol consumption by remotely presenting alcohol-predicting cues and analyzing correlations between behaviors and drinking variables.

This study investigates how dopamine and serotonin affect persistence for delayed rewards in humans, finding that serotonin increases persistence while dopamine has mixed effects.

This study identifies distinct subpopulations of lateral habenula neurons and shows they respond differently to reward-related stimuli during behavior.

The paper uses MALDI-IMS to identify region-specific peptide/protein alterations in rat brain regions after cocaine and cocaine-alcohol exposure, showing distinct molecular profiles.

This study investigates how dopamine signaling in the striatum influences corticostriatal circuits during behavior, finding that learning-related plasticity, not acute dopamine effects, shapes circuit function.

This study shows that silencing the dorsal striatum reduces light self-administration in mice, suggesting a role similar to drug addiction.

This study shows that protein restriction selectively enhances nucleus accumbens dopamine responses to protein-containing food during operant feeding in male mice, depending on nutritional status and task demands.

This study identifies distinct dopaminergic signatures for state and trait-like pessimism in mice using a Pavlovian ambiguous-cue task.

This paper develops an oral fentanyl self-administration model in mice to study escalation and relapse phenotypes, finding genetic background influences on these behaviors.

The paper shows that dopamine dips during unrewarded actions increase punishment-resistant reward seeking in female mice, with optogenetic mimicry accelerating this behavior in both sexes.

The paper investigates dopamine dynamics in the mouse dorsomedial striatum during interval timing and finds that dopamine ramps down before reward delivery, predicts timing behavior, and varies between sexes and with amphetamine.

This study identifies a novel amygdala-dopamine circuit activated by adolescent stress that drives punishment-resistant reward-seeking behavior in mice.

This study shows that cerebellar granule cells and climbing fibers encode dopamine rewards predictively and instructively, contributing to motivated behavior.

This study shows that striatal acetylcholine supports reversal learning by promoting state construction in reinforcement learning.

The paper identifies a rare striatal neuron population, Chst9-MSNs, that is critical for opioid reward and distinct from canonical pathways.

This study examines dopamine dynamics in the nucleus accumbens during positive and negative reinforcement in rats, finding distinct patterns for different reinforcer types and availability.

This study uses pharmacogenetic inhibition of locus coeruleus neurons in monkeys to show that LC activity is critical for cognitive effort during a memory-demanding task.

This study identifies two distinct modes of striatal dopamine release that independently control locomotion and learning.

This study shows that activating astrocyte Gq signaling in the ventral tegmental area affects cocaine-associated behaviors differently in drug-naive and cocaine-experienced rats.

This study identifies VTA glutamatergic inputs to the lateral habenula as critical for mediating the social and nonsocial consequences of uncontrollable stress.

The paper presents a neural circuit model of reinforcement learning in songbirds that demonstrates how temporal and spatial imprecision in dopaminergic signals can be overcome through fast reward prediction updates.

This study shows that early life adversity selectively reduces adult social reward motivation in rodents without affecting sucrose reward motivation.

The paper identifies miR-10a-5p as a molecular regulator of impulsivity in the nucleus accumbens, linking it to dopaminergic signaling and impulsive-compulsive disorders.