Alzheimer's disease research and treatments

This study shows that reducing neuronal mitochondrial calcium uptake in AD mouse models decreases pathology, synaptic dysfunction, and cognitive decline.

This study shows butyrate reduces amyloid-beta 42 accumulation at the blood-brain barrier by activating insulin signaling pathways and improving BBB integrity.

This study identifies twelve phosphomimetic mutations in tau that induce the formation of paired helical filaments in vitro, mimicking Alzheimer's disease structures.

This study identifies early proteomic changes in the retina and brain of 3xTg-AD mice, revealing shared and tissue-specific metabolic and transport dysregulation linked to Alzheimer's disease.

The paper identifies glial cell-specific regulatory elements and genetic risk modifiers in tau-related dementias using single-nucleus epigenomic profiling.

This study shows that kinesin-1 and kinesin-3 mitigate Aβ42Arc toxicity in Drosophila neurons and rescue behavioral defects.

This study identifies Valosin-containing protein (Vcp) as cargo in Amyloid Precursor Protein (APP)-containing extracellular vesicles and shows its role in APP processing and EV secretion in rat neurons.

This study shows that loss of brain insulin production in female mice impairs learning and memory, while having no effect on males.

The paper analyzes longitudinal metabolomic changes of biogenic amines in plasma and CSF of TgF344 AD rats and WT controls, revealing sex- and age-specific differences.

The paper uses single-domain antibodies to investigate how different tau domains influence RNA-induced tau liquid-liquid phase separation, identifying a proline-rich domain as critical for condensation.

The paper investigates how selective reduction of KCNA4 in 5HT/glut neurons of the dorsal raphe nucleus contributes to tau pathology and depressive-like behaviors in Alzheimer's disease.

This study shows taurine inhibits ApoE4 aggregation and reduces its pathophysiological effects, similar to tramiprosate and 3-sulfopropanoic acid.

This study identifies SHIP1 ligands with brain exposure and in vivo activity in Alzheimer's models, showing target engagement and reduced neuroinflammation.

This study identifies and characterizes a novel N-terminally acetylated Tau variant that accumulates in AD models and patients, exacerbates pathology, and is a potential therapeutic target.

The paper identifies genetic factors associated with Alzheimer's disease progression using GWAS and longitudinal data, finding distinct genetic drivers from disease risk.

The paper uses multi-omic analysis to study MAPT V337M neurons, finding altered axonogenesis and tau phosphorylation, with p38 MAPK pathway involvement in tau phosphorylation in V337M neurons.

This study shows that D-methionine improves spatial memory and reduces amyloid pathology and oxidative stress in AD mouse models, with sex-specific effects.

This study shows that glucose hypometabolism and hyperphosphorylated Tau work together to cause neuronal death through necroptosis in a mouse model.

This study identifies a metabolite from E. coli that suppresses tau aggregation in vitro and in live bacteria, suggesting its potential for modulating tauopathies.

This study shows that chronic activation of mGlu2 receptors with a nanobody accelerates amyloid formation and worsens memory deficits in Alzheimer's disease models.

This study shows lactate treatment improves cognitive function and molecular biomarkers in Alzheimer's mice and wild-type controls.

This study shows that adolescent social isolation promotes tau spread in raphe nuclei, causing depression-like and pain-related symptoms in Alzheimer's disease.

This study shows that JQ1, a BET inhibitor, reduces inflammation and hippocampal amyloid-β levels but not Tau phosphorylation in LPS-challenged mice.

The paper develops a minimal mechanistic model showing that protein aggregation can exhibit hormesis, with low-dose stimulation and high-dose inhibition, arising from network topology.

The paper identifies DNA methylation changes in transgenic mouse models of Alzheimer's disease, showing distinct patterns for tau and amyloid-beta pathology and some overlap with human AD data.

This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.

This study evaluates a cell-penetrating peptide (NCAM1-PrP) for its ability to inhibit IAPP aggregation and cytotoxicity in type II diabetes.

This paper uses computational techniques to analyze transcriptomic data and identify common pathways involving BAG family proteins in Alzheimer's and Parkinson's disease.

This study integrates multi-omics data from aged human brains to identify cross-system biological factors and molecular subtypes associated with Alzheimer's disease heterogeneity.