Malaria Research and Control

Variation in spatial population structure in the Anopheles gambiae species complex

This study examines migration patterns among malaria vector species using genomic data, finding variation in genetic differentiation and migration rates across regions and species.

Genomic exploration of the complex journey of Plasmodium vivax in Latin America

This study uses whole genome sequencing of Plasmodium vivax isolates to reveal a complex evolutionary history, showing that current Latin American populations mainly originated from an extinct European lineage with possible West African contributions.

Exploring operational requirements of mixtures for insecticide resistance management in public health using a mathematical model assuming polygenic resistance.

This study evaluates the effectiveness of insecticide mixtures for resistance management using a mathematical model of polygenic resistance, finding that full-dose mixtures are most effective.

A single cell atlas of sexual development in Plasmodium falciparum

This study presents a single-cell transcriptome atlas of Plasmodium falciparum sexual development, revealing transcriptional heterogeneity in naturally infected individuals.

PfHT1 controls glucose uptake in malaria parasite: molecular dynamics study in plasma membrane like environment reveals ligand induced conformational changes trigger closed conformation and alters binding pocket geometry

This study uses molecular dynamics simulations to analyze PfHT1 conformational changes and design specific inhibitors for malaria parasite glucose uptake.

Mathematical Methodology for Dynamic Models of Insecticide Selection Assuming a Polygenic Basis of Resistance

This paper introduces dynamic mathematical models for polygenic insecticide resistance, showing full-dose mixtures remain the best strategy while sequences and rotations are similarly effective.

A single mutation G454A in P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy

This study identifies a single mutation G454A in CYP9K1 as a driver of pyrethroid resistance in Anopheles funestus, reducing bed net efficacy and highlighting the need for resistance monitoring.

Genotyping of paired clinical isolates using PvCSP, PvMSP3α PvMSP3βand exploring STRs to differentiate between relapse and reinfection in P. vivax

This study genotypes paired clinical isolates of Plasmodium vivax using molecular markers to differentiate between relapse and reinfection, identifying relapse episodes in some patients.

Population genomics of Plasmodium ovale species in sub-Saharan Africa

This study performs population genomic analysis of Plasmodium ovale species in sub-Saharan Africa, finding differences in nucleotide diversity and signatures of selection between the two species.

The potential of gene drive releases in malaria vector species to reduce the malaria burden in different African environments

This study models the impact of gene drive releases on malaria transmission in West Africa, showing significant reductions in vector abundance and malaria prevalence when targeting multiple vector species.

Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b drive pyrethroid resistance in Anopheles funestus

This study identifies two mutations in CYP6P4a and CYP6P4b genes driving pyrethroid resistance in Anopheles funestus and develops DNA-based assays to detect these mutations in West Africa.

Estimating multiplicity of infection, allele frequencies, and prevalences accounting for incomplete data

The paper introduces a statistical model to estimate multiplicity of infection and allele frequencies while accounting for incomplete molecular data, finding that it performs better in low-quality data scenarios.

Discovery of knock-down resistance in the major malaria vector Anopheles funestus.

The paper discovers knock-down resistance (kdr) mutations in Anopheles funestus, a major malaria vector, showing resistance to DDT but not deltamethrin.

gARID-associated chromatin remodeling events are essential for gametocyte development in Plasmodium

This study shows that gARID is essential for gametocyte development in Plasmodium by participating in two chromatin remodeling events critical for both male and female gametocytes.

Copy number variants underlie the major selective sweeps in insecticide resistance genes in Anopheles arabiensis from Tanzania.

This study identifies copy number variants (CNVs) as key drivers of insecticide resistance in Anopheles arabiensis, revealing new gene clusters and resistance mechanisms to deltamethrin and pirimiphos-methyl.

Transcriptome analysis reveals a novel DNA element that may interact with chromatin-associated proteins in Plasmodium berghei during erythrocytic development

Inferring a novel insecticide resistance metric and exposurevariability in mosquito bioassays across Africa

The paper introduces a new metric for insecticide resistance in mosquitoes and quantifies exposure variability in bioassays across Africa.

Regional Plasmodium falciparum subpopulations and malaria transmission connectivity in Africa were detected with an enlarged panel of genome-wide microsatellite loci

The paper identifies regional subpopulations and gene flow patterns of Plasmodium falciparum in Africa using genome-wide microsatellite loci from 992 isolates.

Adaptive admixture at ACKR1 (the Duffy locus) may have shaped Plasmodium vivax prevalence in Oman

The paper investigates adaptive admixture at the Duffy locus in Oman, finding evidence of selection for Duffy null alleles linked to reduced P. vivax prevalence.

Role of Seasonal Importation and Random Genetic Drift on Selection for Drug-Resistant Genotypes of Plasmodium falciparum in High Transmission Settings

The paper models how seasonal importation and genetic drift affect the establishment of drug-resistant Plasmodium falciparum genotypes in high transmission settings.

Molecular confirmation of Anopheles stephensi in the Al Hudaydah Governorate, Yemen, 2021-2022.

The paper confirms the presence of Anopheles stephensi in Yemen through molecular analysis of collected mosquito samples.

A single E205D allele of a key P450 CYP6P3 is driving metabolic pyrethroid resistance in the major African malaria vector Anopheles gambiae

This study identifies the E205D mutation in CYP6P3 as a driver of pyrethroid resistance in Anopheles gambiae, showing its association with resistance and its interaction with kdr mutations.

Optical tweezers reveal that PfEBA and PfRH ligands, not PfMSP1, play a central role in Plasmodium-falciparum merozoite-erythrocyte attachment

The paper uses optical tweezers to measure merozoite-erythrocyte attachment forces and identifies PfEBA and PfRH ligands as critical for attachment, not PfMSP1.

Chromatin structure and var2csa - a tango in regulation of var gene expression in the human malaria parasite Plasmodium falciparum?

The paper investigates how var2csa influences var gene expression in Plasmodium falciparum by analyzing chromatin structure changes after gene deletion.

Plasmodium falciparum transmission in the highlands of Ethiopia is driven by closely related and clonal parasites

The paper analyzes P. falciparum genetic diversity and transmission patterns in Ethiopian highlands, finding local transmission and clonal parasite spread.

A rapid, cost-effective, colorimetric LAMP assay (CLASS) for detecting invasive malaria vector, Anopheles stephensi

The paper develops a colorimetric LAMP assay for rapid, cost-effective detection of Anopheles stephensi, showing high sensitivity and specificity without requiring DNA extraction or specialized equipment.

Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity

This study analyzes genetic diversity and selection signatures in the Pfcsp gene of Plasmodium falciparum from Tanzanian regions with varying malaria transmission to inform vaccine development.

A complex Plasmodium falciparum cryptotype circulating at low frequency across the African continent

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.

Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021

The paper analyzes trends of molecular markers of artemisinin resistance and lumefantrine susceptibility in Plasmodium falciparum from 2016 to 2021 in Tanzania, finding an increase in Y184F mutations and NFD haplotypes.

Assessing complex member composition and insecticide resistance status of Anopheles gambiae s.l. in three coastal health districts of Cote d'Ivoire.

This study assesses the composition and insecticide resistance of Anopheles gambiae s.l. in Cote d'Ivoire, finding high pyrethroid resistance and identifying potential alternative insecticides.