Malaria Research and Control

Host-Pathogen Interactions in the Plasmodium-Infected Mouse Liver at Spatial and Single-Cell Resolution

This study uses spatial transcriptomics and snRNA-seq to analyze host-pathogen interactions in P. berghei-infected mouse liver tissues, revealing changes in lipid metabolism and inflammatory responses.

An experimental target-based platform in yeast for screening Plasmodium vivax deoxyhypusine synthase inhibitors

The paper develops a yeast-based platform to identify Plasmodium vivax DHS inhibitors, finding two compounds that selectively inhibit parasite DHS over human DHS.

Multi-protein chimeric antigens, a novel combined approach for efficiently targeting and blocking the blood stage of Plasmodium falciparum

The paper presents a novel vaccine strategy using multi-protein chimeric antigens to target and block the blood stage of Plasmodium falciparum by combining immunodominant peptides from multiple antigens.

Impact of blood meals taken on ivermectin-treated livestock on survival and fecundity of the malaria vector Anopheles coluzzii under laboratory conditions

This study examines how ivermectin-treated livestock affects the survival and fecundity of Anopheles coluzzii mosquitoes under lab conditions, finding significant reductions in mosquito survival and egg production.

Phosphorylation in the Plasmodium falciparum proteome: A meta-analysis of publicly available data sets

This paper performs a meta-analysis of 11 phosphoproteomics datasets to identify phosphorylated sites in Plasmodium falciparum and related species, revealing sequence motifs, conservation patterns, and structural context of phosphosites.

Inference for entomological semi-field experiments: Fitting a mathematical model assessing personal and community protection of vector-control interventions

The paper develops a Bayesian inference method to assess personal and community protection of vector-control interventions using semi-field experimental data.

Malaria parasite resistance to azithromycin is not readily transmitted by mosquitoes

The paper shows that azithromycin resistance in malaria parasites reduces their transmission via mosquitoes, suggesting it could help control drug resistance.

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

The paper identifies genetic determinants of multidrug resistance in Plasmodium falciparum and their impact on parasite fitness and drug susceptibility.

Genetic validation of PfFKBP35 as an antimalarial drug target

This study genetically validates PfFKBP35 as a lethal target in Plasmodium falciparum, showing its role in ribosome homeostasis and revealing non-canonical modes of action for FK506.

Metabolic changes that allow Plasmodium falciparum artemisinin-resistant parasites to tolerate the oxidative stress

The paper identifies metabolic changes in artemisinin-resistant Plasmodium falciparum parasites that enable oxidative stress tolerance through increased glutathione production and altered TCA cycle flux.

The spread of a validated molecular marker of artemisinin partial resistance pfkelch13 R622I and association with pfhrp2/3 deletions in Eritrea

The paper investigates the spread of the pfkelch13 R622I mutation and its association with pfhrp2/3 deletions in Eritrea following the switch from HRP2-based RDTs.

MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites

MalariaSED predicts chromatin profiles in malaria parasites and identifies noncoding variants linked to invasion and drug resistance.

A new Plasmodium vivax reference genome for South American isolates

This paper presents a new high-quality reference genome for South American Plasmodium vivax isolates, showing improved representation compared to existing genomes.

Dirus Complex Species Identification PCR (DiCSIP) improves identification of Anopheles dirus complex from Greater Mekong Subregion

This paper develops a new PCR assay, DiCSIP, to accurately identify Anopheles dirus complex species, improving upon the unreliable Dirus AS-PCR method.

Evolution of hierarchical switching pattern in antigenic variation of Plasmodium falciparum under variable host immunity

The paper shows that variable switching rates of var genes in Plasmodium falciparum provide an evolutionary advantage by optimizing parasite survival under host immune pressure.

A genomic platform for epidemiological surveillance and vaccine antigen discovery using long-read amplicon sequencing

The paper introduces a genomic platform using long-read sequencing to monitor pathogen diversity and identify vaccine antigens in multiclonal infections.

Overexpression and nonsynonymous mutations of UDP-glycosyltransferases potentially associated with pyrethroid resistance in Anopheles funestus

The paper identifies overexpression and nonsynonymous mutations in UGT genes associated with pyrethroid resistance in Anopheles funestus using GWAS-PoolSeq and transcriptomic analysis.

Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells

The paper identifies novel proteins in Plasmodium falciparum gametocyte egress vesicles using imaging and BioID, revealing distinct proteomes for osmiophilic bodies and g-exonemes.

Cost-effectiveness of Precision Guided SIT for Control of Anopheles gambiae in the Upper River Region, The Gambia.

This paper evaluates the cost-effectiveness of precision-guided sterile insect technique (pgSIT) for malaria control in The Gambia, finding it to be a cost-effective and economically beneficial approach.

Epigenetically-regulated RNA-binding proteins signify malaria hypnozoite dormancy

The paper identifies epigenetically silenced RNA-binding proteins in malaria hypnozoites and proposes they regulate dormancy and reactivation.

Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design

This paper identifies a small molecule inhibitor of Plasmodium falciparum myosin A, showing it blocks ATP hydrolysis and parasite growth.

coiaf: directly estimating complexity of infection with allele frequencies

The paper introduces two methods to directly estimate malaria parasite complexity of infection from allele frequency data, showing comparable accuracy to existing methods and identifying continental differences in COI.

A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

The paper introduces a new computational pipeline for var gene expression analysis, showing changes in var gene expression and core transcriptome during in vitro culture of Plasmodium falciparum.

Using a P. falciparum genetic cross to dissect the relative contributions of pfcrt and plasmepsin II/III to piperaquine response-related traits

This study uses a genetic cross of Plasmodium falciparum isolates to analyze the roles of pfcrt and pm2/3 in piperaquine resistance and fitness traits.

The Parasite Intraerythrocytic Cycle and Human Circadian Cycle are Coupled During Malaria Infection

The paper shows that the host circadian cycle and parasite intraerythrocytic cycle are coupled in P. vivax infections, suggesting potential therapeutic targets.

Aeroplane wing, a new recessive autosomal phenotypic marker in malaria vector, Anopheles stephensi Liston

The paper describes a new recessive autosomal mutant in Anopheles stephensi with an aeroplane wing phenotype, characterized by its genetic inheritance and cytogenetic features.

Investigating the ATP binding pocket of CX3CL1 binding protein 2 using in silico approach

This study identifies the ATP binding pocket of CBP2 using in silico methods and characterizes potential interactions and residues involved.

PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages

This study identifies PfAP2-MRP as a master regulator controlling parasite growth, chromatin structure, and var gene expression during malaria parasite blood stages.

The Computational Analysis of Plasmodium falciparum Heat Shock Proteins Reveals an Interplay with Polyamines

This paper investigates the computational interaction between polyamines and heat shock proteins in Plasmodium falciparum to identify potential drug targets for malaria treatment.

Upregulation of steroidogenesis is associated with coma in human cerebral malaria

The paper identifies steroid biosynthesis as a key metabolic pathway associated with coma in cerebral malaria by analyzing metabolite differences between CM and CM-like patients.