DNA Repair Mechanisms

This paper identifies homoharringtonine as a DDR inhibitor that targets XPC to impair DNA repair and enhance platinum-based chemotherapy efficacy.

This paper investigates how (AAGGG)n repeats in the RFC1 gene cause DNA replication fork stalling and reversal, implicating G4-DNA and SMARCAL1 in the process.

The paper reveals that RPA activates TMEJ by facilitating ssDNA hand-off to Polθ, which initiates microhomology search for DNA repair.

The paper develops a cell-free system using Xenopus egg extracts to study TMEJ, showing that Pol theta and Cyclin B-CDK1 are essential for efficient DNA joining.

This study shows DNA-PK enforces the S/G2 checkpoint in ATM-deficient cells, reducing ATR inhibitor efficacy, and suggests combining ATR and DNA-PK inhibition could enhance treatment in such cancers.

This study identifies AtSUV3 as a mitochondrial RNA helicase involved in DNA repair and shows its role in mitigating DNA damage in Arabidopsis.

This study identifies Kcs1-dependent inositol pyrophosphates as regulators of DNA repair via Pho80-Pho85 in budding yeast, independent of homologous recombination.

This study reconstructs the plant organellar homologous recombination pathway in Arabidopsis, showing that AtRecA1-mediated recombination is enhanced by plant-specific ssDNA-binding proteins, while AtRecA2 and AtRecA3 require these proteins for activity.

This study identifies DHX30 as an R-loop helicase that resolves RNA:DNA hybrids, prevents replication stress, and maintains genome stability in human and zebrafish cells.

This study models human MLH1 and MLH3 variants in mice, revealing MutLγ's roles in meiotic DNA repair and ovarian reserve maintenance through multiple mechanisms.

The paper identifies RPA as a critical factor for polymerase theta-mediated end joining and shows how RPA facilitates this process through a direct interaction with Polθ.

This study shows c-di-AMP binds to Mycobacterium smegmatis RadA at a non-catalytic site, reducing its DNA-stimulated ATPase activity.

This study shows WRN deficiency causes oncogenic rearrangements at TA-rich tandem repeats by destabilizing them, leading to chromosomal breaks and activation of TERT in melanoma.

The paper shows that the replication checkpoint reduces transcription to prevent fork stalling and replication stress in yeast and human cells.

The paper identifies a specific mutation pattern in mismatch-repair-deficient cancers linked to DNA hole delocalization and oxidation, showing enrichment at 5' guanines and depletion at 3' guanines.

The paper shows RecA* structure dynamics predict spontaneous cell death in E. coli by linking SOS response magnitude to DNA repair kinetics.

The paper identifies Firrm as a platform coordinating Mcm8-9-Hrob recruitment and Fignl1-mediated Rad51 unloading during homologous recombination.

The paper shows that constitutive ATR signaling coordinates replication origin firing across domains, and stress disrupts this coordination by sequestering ATR.

This study identifies NEIL2 as a regulator of RNA polymerase II dynamics that suppresses transcription replication conflicts in pancreatic cancer cells.

This study identifies ATR as a master regulator of the oocyte meiotic prophase checkpoint and defines a BRCA1-ATR signaling axis linking chromosome asynapsis to oocyte elimination.

This study reveals the structural mechanism of aphidicolin inhibition of human DNA polymerases Pol δ and Pol ε, showing how it blocks DNA synthesis by altering the polymerase conformation.

The paper identifies a distributed architectural code involving cytoskeletal, membrane, and lipid regulators that governs nuclear reshaping during DNA repair.

This study investigates how ATM, ATR, and DNA-PK signaling differ in their roles during meiotic recombination and postnatal DNA damage response in mouse oocytes, revealing distinct pathways for oocyte elimination.

The paper investigates how regulatory and catalytic domains of ADP-ribosyltransferases co-evolve, showing functional complementarity across species and enzyme classes.

This study shows that NNK induces acute DNA damage and chronic HR repair dysregulation in pancreatic cells, linked to genomic instability and poor prognosis in PDAC.

This study defines the composition and architecture of the synaptonemal complex building block in C. elegans and shows how its subunits assemble into higher-order structures.

The paper shows that nucleosomes enhance DNA polymerase β activity in linker DNA and that PARP1/PARP2 regulate this activity and BER sub-pathway choice.

The paper investigates the role of small non-coding RNAs (diRNAs) in DNA double-strand break (DSB) repair in Arabidopsis thaliana and finds they are not essential for repair but may silence damaged genes post-transcriptionally.

This study shows that replication stress causes genes to detach from nuclear pores, coordinated with fork progression, and that checkpoint kinases Mec1/ATR and Rad53/CHK1 regulate this process in a stepwise manner.

This study uses single-cell proteomics to show that DNA damage causes heterogeneous and bimodal proteome responses in U2 OS cells, revealing cell-to-cell variability obscured by bulk analysis.