Multiple Sclerosis Research Studies

The paper analyzes genetic susceptibility to multiple sclerosis (MS) using epidemiological data, showing that only a small subset of the population is genetically susceptible, and that environmental factors and stochastic elements also play critical roles.

This study shows that enhancing the integrated stress response (ISR) improves remyelination in inflammatory CNS lesions in mice.

The paper analyzes the transcriptome of an NR1H3 mouse model of multiple sclerosis, identifying dysregulated genes and pathways associated with pro-inflammatory and immune response changes.

This study uses optical coherence tomography to monitor remyelination in MS patients and validates the therapeutic potential of VP3.15 as a remyelinating drug.

This study uses MRI to identify meningeal inflammation in a mouse model of multiple sclerosis and shows that BTK inhibition reduces inflammation.

The paper identifies hsa-miR-106a-5p as a dysregulated miRNA in MS patients, showing its potential as a biomarker for diagnosis.

The paper examines MS patient macrophages and finds they exhibit a pro-inflammatory transcriptomic and metabolic profile, suggesting intrinsic immune cell memory and potential therapeutic targets.

This study uses dual-calibrated fMRI to show reduced oxygen supply and consumption in MS patients without changes in oxygen extraction, suggesting impaired oxygen utilization or transfer.

This study shows that thyroid hormone and thyromimetics reduce disease severity and protect oligodendrocytes in EAE by decreasing myelin and axonal degeneration.

The paper shows that C57BL/6NTac mice are more susceptible to cuprizone-induced demyelination than C57BL/6J mice, highlighting variability between substrains.

The paper shows that neuroinflammation in MS brains causes structural changes at the node of Ranvier, leading to axonal conduction failure.

The paper shows MS-derived oligodendroglia can myelinate axons and form functional connections in a mouse model, suggesting the differentiation block is due to environmental factors, not intrinsic deficits.

This study uses Mendelian randomization to assess if smoking causally affects multiple sclerosis risk, finding no significant association.

This study shows that early postnatal tobacco smoke exposure worsens experimental autoimmune encephalomyelitis in adult rats by reducing regulatory T cells and increasing inflammation.

This study shows that multiple sclerosis alters higher-order BOLD responses in BA 4p but not BA 4a during grip force tasks, beyond the main effect of movement.

This study shows that environmental enrichment reduces relapse incidence and severity in experimental autoimmune encephalomyelitis, counteracting the effects of repeated acute stress.

This paper investigates whether demyelination in multiple sclerosis leads to selective neurodegeneration of inhibitory interneurons and presents a rodent model to study this phenomenon.

This study identifies Gsta4 as a regulator of apoptosis in adult oligodendrocyte differentiation and remyelination, showing its role in modulating the Fas/Casp8/Bid mitochondrial axis.

This study identifies a primed chromatin state in oligodendroglia that facilitates rapid activation of immune gene programs in multiple sclerosis.

The paper examines working memory performance in MS patients and healthy controls, finding altered frontal-to-parietal connectivity in MS patients that correlates with working memory capacity.

The paper compares gene expression profiles of demyelinated white and grey matter in MS patients, finding minimal overlap and distinct glial cell signatures.

The paper develops and validates a 5-minute AI-based cognitive test (ICA) for MS patients, showing high reliability, validity, and accuracy in detecting cognitive impairment.

This study evaluates cerebellar function scores in relation to axonal loss in multiple sclerosis using diffusion MRI and clinical assessments.

The paper links NAT8L mRNA oxidation to reduced NAA levels and neurodegeneration in multiple sclerosis.

This paper performs a coordinate-based meta-analysis to identify consistent grey matter loss in MS and CIS patients, finding significant clusters and correlations with disease duration.

This study compares the effects of vitamin D2 and D3 on gene expression in rat oligodendrocyte precursor cells during differentiation, finding distinct gene expression changes associated with each form.

The paper segments and tracks white matter lesions in MS patients, finding that transformation of diffuse abnormal white matter to focal lesions correlates with clinical progression.

This study shows bile acid metabolism is altered in multiple sclerosis, and supplementation with tauroursodeoxycholic acid reduces neuroinflammation in animal models.

This study investigates complement-dependent synapse loss and microgliosis in EAE mice, finding that C3 knockout reduces synapse loss and microglial activation.

This paper automates the separation of focal white matter lesions and diffusely abnormal white matter in MS using MRI intensity thresholds and finds MTR values are lower in focal lesions compared to diffusely abnormal white matter.