Hepatitis C virus research

Integrated transcriptomic analyses identifies host-targeting repurposing drugs for hepatitis C virus infection and related hepatocellular carcinoma

The paper identifies repurposing drugs targeting host genes for HCV infection and related HCC by analyzing transcriptomic data from human liver tissues.

Phosphatidylinositol Phospholipids Modulate Hepatitis C Virus Core Protein Assembly on Lipid Membranes

This study investigates how phosphatidylinositol phospholipids modulate HCV core protein assembly on lipid membranes, showing that PI(4)P enhances HCC multimerization and capsid formation.

Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein

This study generates bispecific antibodies targeting two distinct HCV E1E2 epitopes, showing enhanced neutralization breadth and potency compared to monospecific antibodies.

Lineage-aware evolutionary analysis of hepatitis C virus within-host dynamics

This study analyzes HCV within-host dynamics post-DAA treatment failure, finding persistent viral subpopulations and lineage-specific evolutionary rates.

The Polymorphisms, Solvent Accessibility and Conservatism of Hepatitis C Virus Nonstructural 5B Protein

The paper analyzes polymorphisms and conservatism in the HCV NS5B protein, finding solvent accessibility predicts polymorphism and purifying selection drives both polymorphism and conservatism.

Temporal dynamics of viral fitness and the adaptive immune response in HCV infection

This study examines how viral fitness and immune responses interact in HCV infection, showing fitness decreases early but rebounds with mutations, and strong CD8+ T-cell responses drive chronic infection.

Defining the multiplex probe panel for detecting mutating viruses with high clinical sensitivity

The paper develops a multiplex probe panel strategy to improve clinical sensitivity for detecting mutating viruses, achieving 89% sensitivity for hepatitis C virus.

The RdRp Thumb-1 Pocket is a Conserved Target for Broad-Spectrum Antiviral Development

The paper identifies the RdRp Thumb-1 pocket as a conserved target for broad-spectrum antivirals, validated through structural and biochemical analyses of multiple viruses.

Structure of the hepatitis C virus E1/E2 envelope proteins in a homodimeric complex

The paper determines the structure of HCV E1/E2 envelope proteins in a homodimeric complex using cryo-electron microscopy, revealing details about the dimer interface and antigenic sites relevant to vaccine design.

The non-structural proteins NS3 and NS5A of Hepatitis C Virus (HCV) are degraded by two host proteolysis systems

The paper quantifies the half-lives of HCV NS3 and NS5A proteins under proteolysis system modulators and shows their polyubiquitination and co-localization with autolysosome and proteasome components.

HCV E1 influences the fitness landscape of E2 and may enhance escape from E2-specific antibodies

The paper investigates how E1-E2 interactions in HCV affect viral fitness and antibody escape, identifying mutations and antibodies with implications for vaccine development.

An Entropic Safety Catch Controls Hepatitis C Virus Entry and Antibody Resistance.

This study identifies HVR-1 as an autoinhibitory region in HCV E1E2 that suppresses viral entry through conformational entropy, which is released upon receptor binding to enhance entry but reduce antibody resistance.

Comparison of simple RNA extraction methods for molecular diagnosis of hepatitis C virus in plasma

The paper compares RNA extraction methods for HCV detection in plasma, finding magnetic beads-based extraction is suitable for on-site testing while boiling methods have limitations.

The cellular poly(rC)-binding protein 2 prevents the early steps of hepatitis C virus virion assembly

This study identifies PCBP2's role in limiting HCV virion assembly and shows that an alternative RNA conformation facilitates assembly independently of PCBP2.

Structural studies of hepatitis C virus non-structural protein-5b of genotype 4a

The paper reports the X-ray structure of HCV genotype 4a NS5b, an RNA-dependent RNA-polymerase, to aid in structure-based drug design.

A genomic variant of ALPK2 is associated with increased liver fibrosis risk in HIV/HCV coinfected women

The paper identifies a genomic variant in ALPK2 associated with increased liver fibrosis risk in HIV/HCV coinfected women using clinical data from the WIHS cohort.

Required concentration index quantifies effective drug combinations against HCV infection

The paper introduces a required concentration index to rank antiviral efficacy of HCV drug combinations and shows multidrug treatments enhance activity but reduce genotype-specific efficacy.

Quantitative differences between intra-host HCV populations from persons with recently established and persistent infections

The paper compares intra-host HCV population characteristics between recent and persistent infections, finding significant differences and developing a machine learning classifier with 95.22% accuracy.

Identification of characteristic genomic markers in human hepatoma Huh7 and Huh7.5.1-8 cell lines

The paper identifies genomic deletions and mutations in Huh7 and Huh7.5.1-8 cell lines that may serve as markers for cell authentication and distinguish between the two lines.

Impact of virus subtype and host IFNL4 genotype on large-scale RNA structure formation in the genome of hepatitis C virus

The paper examines how HCV virus subtype and host IFNL4 genotype influence genome-scale RNA structure formation and compositional features in HCV.

Pervasive adaptation of hepatitis C virus to interferon lambda polymorphism across multiple genotypes

This study identifies associations between IFN-lambda polymorphism and HCV variation across multiple genotypes and ancestries, showing viral adaptation to host immune pressure.

Resistance from Afar: Distal Mutation V36M Allosterically Modulates the Active Site to Accentuate Drug Resistance in HCV NS3/4A Protease

This study investigates how the distal mutation V36M confers drug resistance in HCV NS3/4A protease through allosteric modulation of the active site, in the context of R155K.

Interferon lambda 4 impacts broadly on hepatitis C virus diversity.

The paper examines the impact of IFN-lambda4 on HCV diversity using host and viral genetic data from 485 patients, finding that IFN-lambda4 variants influence viral amino acid diversity and load.