Developmental Biology and Gene Regulation

This study shows that changes in vertebral regionalisation in African cichlids are driven by somite number changes, with homeotic effects as a by-product, and that intraspecific variation is canalised and decoupled from macroevolutionary patterns.

The paper shows how Fgf signaling and mechanical forces affect rosette formation in zebrafish primordium migration.

The paper identifies a rare secretory cell type in the intestine, CHEs, and shows that a second wave of Notch signaling is required for their specification.

This study identifies transcription factor feedback loops that maintain and restore touch sensation in C. elegans by securing interneuron identity and function.

This study identifies ventral cluster cells as electrocyte progenitors in electric eels, showing their transformation into mature electrocytes through dorsal migration and cell fusion.

The paper investigates how signaling pathways regulate stem cell precursor fates and proliferation during Drosophila pupal ovary development, finding similarities to adult stem cell behavior.

The paper identifies two regulatory modules that control the sequential transition between early and late gastrulation modes in mouse gastruloids.

The paper identifies Cse1l as critical for neural crest cell survival, showing that its genetic ablation leads to embryonic lethality and increased apoptosis with p53 expression.

The paper uses ATAC-seq to analyze chromatin accessibility during embryonic development in Hofstenia miamia, identifying regulatory mechanisms and gene networks involved in differentiation.

This paper investigates the role of the gcl gene in germ cell development across three insect species, finding divergent functions in germ cell specification and number.

This study shows Notch2 drives canonical Notch signaling in smooth muscle differentiation, while Notch3 requires higher doses to activate transcription due to weaker RBPJκ interaction, with implications for artery-specific diseases.

The paper tests Oskar variants in vivo to assess their role in germ plasm assembly, finding that the LOTUS domain is critical for mRNA recruitment despite the current model attributing this function to the OSK domain.

The paper identifies Upd2 as a critical factor promoting tumorous growth by converging oncogenic Ras, Yki, and Notch signals in Drosophila imaginal discs.

The paper identifies CMTM4 as a gene regulating PMC migration and skeletal patterning in sea urchin embryos through adhesive mechanisms.

The paper analyzes gene duplication and sub-functionalization in the wing gene regulatory network of pea aphids, finding limited morph-biased expression and functional divergence in duplicated genes.

The paper investigates the role of Kruppel-like factors in regulating pluripotency and neural crest stem cell formation in Xenopus and lamprey, finding that klf17, not klf4, is ancestral in these processes.

This paper analyzes the evolutionary dynamics of FoxQ2 transcription factors across metazoans, identifying three ancient paralogs and revealing conserved and novel expression patterns in chordates.

The paper tests whether scale-invariant morphogen gradients maintain wing patterning in Drosophila under environmental size changes and finds they do not.

This study defines 26 developmental stages of pre-oviposition development in the brown anole, revealing divergence from chicken embryogenesis and providing insights into organ system morphogenesis.

The paper shows that glycolytic activity regulates germ layer proportions by modulating Nodal and Wnt signalling in mouse gastrulation.

This study shows how PAR-3/aPKC cooperativity establishes cell polarity in C. elegans zygotes through multivalent assembly, with PLK-1 regulating its downregulation during polarity maintenance.

This study investigates the evolutionary trends in skeletal cell type emergence, finding that lineage-specific genes drove the diversification of osteoblasts and hypertrophic chondrocytes from an ancestral chondrocyte-like state.

The paper shows that Numb acts alongside BMP signaling to ensure robust intestinal stem cell self-renewal in Drosophila midgut, particularly when BMP signaling is compromised.

The paper characterizes the avascular mesenchyme during digit outgrowth, finding it essential for patterning and revealing a distinct transcriptional identity and unexpected relationship with phalanx formation.

The paper creates a single-cell RNA sequencing atlas of gene expression during mouse cranial neural tube closure, identifying spatially regulated genes and SHH-regulated programs in different brain regions.

The paper shows that tissue spreading during epiboly in chicken embryos reorganizes the extracellular matrix to establish blastoderm architecture and polarity.

The paper examines skin development and metamorphic rearrangement in Arthroleptella villiersi, finding similarities with aquatic anurans and correlations with thyroid gland maturation.

The paper identifies hominoid-specific transposable elements that regulate neural crest migration genes, showing their role in craniofacial evolution.

The paper investigates Notch-induced lineage conversion in mammary basal cells using single-cell transcriptomics and shows that proliferation is essential for the transition to luminal progenitors.