Developmental Biology and Gene Regulation

This study shows that Cullin3 enhances aPKC activity to localize Numb at the basal cortex, promoting differentiation of Drosophila neural stem cell progeny by downregulating Notch signaling.

The paper proposes a three-component model of the spinal nerve branching pattern based on embryonic compartments and validates it using mouse embryos.

This study examines how external perturbations and genetic variation affect the final position of QR.pax cells during migration in C. elegans.

The paper identifies a fibroblast-to-myoblast conversion driven by BMP signalling at the muscle-tendon interface during limb development.

The paper develops a theoretical model to study the spatiotemporal dynamics of signaling and transcription factor networks in spinal cord neural maturation.

The paper shows Fgf/Ets signalling in ectoderm cells initiates neural induction and patterning autonomously, independent of Bmp signals, and activates position-specific neural genes along the anteroposterior axis.

This study shows that Notch signaling regulates arterialization by suppressing cell cycle and metabolism rather than driving differentiation.

This study identifies hingepoints and neural folds in zebrafish forebrain development, revealing conserved neurulation features previously thought unique to amniotes and amphibians.

The paper critiques previous studies on Drosophila ovary follicle stem cells (FSCs), supporting Reilein et al.'s findings of multiple FSCs per ovariole and challenging earlier claims of only two FSCs.

This study uses Gastruloids to show that endoderm progenitors maintain epithelial identity and develop into distinct gut regions without extraembryonic tissues.

This study identifies Akt's role in dorsal aorta formation by showing it sustains arterial progenitor specification and segregation in zebrafish.

The paper shows C. elegans embryos adjust cell division timing in response to temperature gradients to maintain developmental fidelity.

This study identifies Lmo7a as a regulator of neural crest cell migration and lineage specification by modulating cell adhesion and Wnt signaling.

This study shows Brachyury (Bra) is not a unitary master regulator of notochord fate in Ciona, but functions in a feedforward network with Foxa.a.

This study examines evolutionary changes in left-right visceral asymmetry in Astyanax cavefish, identifying maternal genetic effects and regulatory changes in the lft2 gene.

This study introduces a simple in utero injection method to introduce gene expression vectors into endo- and ectodermal cells of mouse embryos before neural tube closure, enabling tissue-specific labeling and analysis of gene function.

The paper identifies Psi as a repressor of developmental pathways that promotes Drosophila wing growth by both activating Myc and repressing growth inhibitors.

This study identifies partner proteins and interaction domains of Xenopus Sox11 involved in neurogenesis, showing species-specific interactions and functional roles.

The paper shows how the SCF/KIT pathway enables self-organised epithelial patterning through cell movement and interactions in Xenopus embryos.

The paper investigates Pax6 haploinsufficiency in mice and finds increased TSH-producing cells and altered thyroid hormone levels, suggesting a new role for Pax6 in endocrine development.

This study identifies ID4 as a repressor of myoepithelial differentiation in mammary stem cells through its interaction with HEB, using integrated transcriptomic, proteomic, and ChIP-sequencing data.

The paper investigates how abdominal spot rows in three Drosophila species evolved by examining mRNA expression patterns of pigmentation genes during pupal development.

This paper proposes a unified mechanism for spatiotemporal patterns in somitogenesis by integrating Notch-Delta coupling with a morphogen gradient.

The paper shows that epithelial integrity guides neuromast positioning in medaka's posterior lateral line, independent of neuronal wiring.

The paper identifies Hes1 as a marker for early perichondrial skeletal progenitor cells using single-cell RNA-seq and lineage tracing in endochondral bone development.

This paper shows that Groucho/TLE regulates axial and hypaxial motor neuron development through non-canonical WNT signaling and suppresses hypaxial traits.

The paper examines ZNF423 orthologs across vertebrates and invertebrates, finding strong sequence constraint in vertebrates but domain-level plasticity in invertebrates.

The paper shows that innate immune signaling via Relish drives the elimination of losing stem cells during competition in Drosophila testis.

The paper uses single-cell RNA sequencing to analyze branchial arch development in chick embryos, identifying novel cell type markers and a conserved transcriptional signature of invasive neural crest cells.

This study investigates the regulatory functions of Sp8 and Sp6 in limb bud ectoderm development using ChIPmentation-seq and RNA-seq, revealing their distinct and cooperative roles in limb patterning.