Developmental Biology and Gene Regulation

The paper investigates gene family evolution across Pancrustacea, finding that transitions to metamorphic development are associated with gene family expansions and functional convergence.

This study identifies distinct transcriptional programs in zebrafish cranial motor neurons during development, showing that identity precedes axon targeting and is conserved across species.

The paper investigates craniofacial genetic network evolution in syngnathid fishes using multiomics data, finding conserved core networks with localized changes contributing to morphological diversity.

This study creates a transcriptomic atlas of early Arabian killifish embryo development, identifying transcriptional modules across developmental stages and highlighting a delayed zygotic genome activation.

This paper shows how the spider venom gland evolved by integrating three distinct developmental programs: appendage patterning, secretory epithelium maintenance, and myogenic metabolism.

The paper identifies temporally distinct CDX-driven regionalisation events that preconfigure vagal and trunk neural crest identities in mouse embryos.

This study identifies gluconeogenesis in the epidermis and endoderm of Xenopus tropicalis embryos, showing its role in development and highlighting tissue-specific metabolic diversity.

The paper shows that chromatin accessibility and co-factor availability determine ASCL1's ability to reprogram cells across different tissues in Xenopus embryos.

The paper identifies molecularly distinct cell populations in the zebrafish isthmic region using scMultiome and validates findings in vivo.

The paper shows LIN-66, a cold shock domain protein, works with microRNA pathways to control developmental timing by limiting early fate regulators' persistence.

This study reconstructs the evolutionary history of temporal transcription factor series in insect visual brains, showing conserved patterns and species-specific variations that influence neuronal diversity.

This study identifies Taqpep as a conserved mediator of periodic patterning in mammalian tissues, showing its role in both skin and intestinal development through mutant mouse models.

The paper compares cellular behaviours during insect gastrulation, finding divergent mechanisms between Drosophila and Tribolium, with nuclear crowding influencing internalisation modes.

This study constructs a cross-species spinal interneuron atlas and shows that Hox-dependent regionalization of circuits drives motor output diversity across vertebrate body regions.

The paper identifies late embryonic developmental changes in penguin forelimbs that lead to flattened bone morphology and reduced musculature, driven by molecular programs associated with tendon-attachment sites.

The paper identifies transcriptional programs controlling terminal differentiation of uv1 paraneurons in C. elegans, revealing shared regulatory mechanisms with canonical neurons.

This study investigates the distinct roles of Smad1 and Smad5 in BMP signaling during mouse ESC differentiation into dorsal interneurons, showing they have different impacts on cell fate specification.

The paper shows that PAR-3 proteins form stable clusters during anoxia in C. elegens embryos, preserving polarity information for rapid reactivation after metabolic arrest.

This study reconstructs the evolutionary assembly of a conserved cortical axis across vertebrates using spatial transcriptomics and single-nucleus RNA-seq, revealing conserved molecular programs and convergent evolution in brain circuitry.

The paper shows that the Shh-p27Kip1 pathway in avian ZPAs controls digit number and identity, and demonstrates that manipulating this pathway can transform chick legs into mammalian-like pentadactyl limbs.

The paper uses single-cell transcriptomics to study the zebrafish sox17 lineage during gastrulation, revealing transcriptional changes in endoderm and dorsal forerunner cells.

This study shows that pax6 is critical for dorsoventral patterning and nerve cord development in Platynereis, supporting a conserved role in bilaterian nervous system evolution.

The paper shows that anal fin-ray number in medaka is influenced by two heritable traits: anal fin length and interval between rays, with temperature affecting these traits.

The paper shows that in annual killifish, neutrophils develop before gastrulation, challenging the conserved BMP-driven myeloid lineage model.

This study shows that Pax9 is essential for anterior identity and proper deployment of sclerotome cells in the caudal fin of zebrafish, leading to fusion with the anal fin and altered skeletal development.

The paper shows that cells specify fate within an optimal window of positional information during zebrafish neurulation, where Shh gradient information peaks early and declines despite increasing signal activity.

The paper investigates muscle loss as a key evolutionary step in turtle shell development using multi-modal imaging and histology-based deep learning to analyze turtle embryos.

This study shows Foxa2 maintains floor plate identity and regulates Sonic hedgehog signaling in zebrafish spinal cord development.

The paper shows that mature neurons use a bistable switch to prevent transdifferentiation, with conserved mechanisms in Drosophila and humans.

This study shows how myosin II polarity and tissue-scale forces influence oriented cell division in Drosophila embryos, with distinct mechanisms in ventral mesectoderm and lateral neuroectoderm.