Head and Neck Cancer Studies

A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

This paper develops a machine learning model to predict radiosensitivity in nasopharyngeal carcinoma using gene expression data and validates its association with immune characteristics and signaling pathways.

Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma

This study identifies molecular differences between HPV-associated and HPV-independent SNSCC, showing HPV drives tumorigenesis and suggesting YAP/TAZ and PI3K inhibition as therapeutic targets.

Analysis of Divergent Gene Expression between HPV+ and HPV- Head and Neck Squamous Cell Carcinoma Patients

This study compares gene expression profiles between HPV+ and HPV- HNSCC using RNA-seq data from the PanCancer Atlas 2018, identifying distinct molecular features associated with HPV status.

Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma

This study establishes patient-derived tumor organoids (PDOs) from 31 HNSCC patients, faithfully recapitulating tumor characteristics and predicting cisplatin responses, revealing hEMT-driven resistance and AREG as a therapeutic target.

Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer

This study shows cigarette smoke exposure drives aggressive head and neck cancer by altering oxidative stress response and immunity through Nrf2 activation and metabolic reprogramming.

Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability

This study identifies molecular traits distinguishing HPV+ oropharyngeal cancer recurrence, showing reduced genomic instability contributes to tumor progression and immune suppression.

Large-Scale Whole-Exome Sequencing Association Study Implicates Genetic Effects on Viral Oncogenesis and Tumor Microenvironment in Nasopharyngeal Carcinoma

This study identifies three novel germline variants associated with nasopharyngeal carcinoma risk and introduces a refined polygenic risk score linked to EBV infection.

Multi-omic profiling identifies malignant subpopulations and a hypoxia-driven angiogenic axis as therapeutic vulnerabilities in sinonasal squamous cell carcinoma

External validation of prognostic and predictive gene signatures in head and neck cancer patients

The paper externally validates five gene signatures in head and neck cancer patients, showing their prognostic and predictive value for treatment outcomes.

Proteogenomic Characterization of Primary Oral Squamous Cell Carcinomas Unveils the Extracellular Matrix Remodeling and Immunosuppressive Microenvironment Linked with Lymph Node Metastasis

This study identifies molecular alterations in oral squamous cell carcinoma linked to lymph node metastasis through multi-omics analysis.

Senataxin modulates resistance to cisplatin through an R-loop mediated mechanism in HPV-associated Head and Neck Squamous Cell Carcinoma

This study shows that senataxin modulates cisplatin resistance in HPV-associated head and neck cancer through R-loop regulation, with higher R-loop burden in HPV+ tumors and metastases.

Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Cancers Identifies KMT2C as a Potential Tumor Suppressor

The paper analyzes the mutational profile of hypopharyngeal and laryngeal cancers, identifying KMT2C as a potential tumor suppressor through in vitro experiments.

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

This study uses Mendelian randomization to assess the causal effect of sexual behavior on oropharyngeal cancer risk, finding attenuated associations after adjusting for confounders.

Clinicopathological characteristics and survival of lymphoepithelial carcinoma of the oral cavity and pharynx: a population-based study

This study analyzes clinicopathological features and survival outcomes of lymphoepithelial carcinoma in the oral cavity and pharynx using SEER data, identifying key prognostic factors and developing a nomogram for survival prediction.

HPV detection and genotyping of FFPE head and neck cancer biopsies by molecular testing to address new oropharyngeal squamous cell carcinoma classification based on HPV status

This study compares two HPV detection assays on FFPE head and neck cancer biopsies, finding good agreement with some discrepancies due to low viral load.

Distinct co-expression networks using multi-omic data reveal novel interventional targets in HPV-positive and negative head-and-neck squamous cell cancer

This study identifies distinct co-expression networks in HPV+ and HPV- HNSCC using multi-omic data, revealing novel therapeutic targets and regulatory mechanisms.

The interplay of immune components and ECM in oral cancer

The paper investigates the role of extracellular matrix (ECM) and immune components in Oral Squamous Cell Carcinoma (OSCC), finding that ECM upregulation and immune cell infiltration are key factors in tumor invasion.

Molecular Mechanisms Of Human Papillomavirus-Related Carcinogenesis In Head And Neck Cancer

This review explores the molecular mechanisms of HPV-related carcinogenesis in head and neck cancer, focusing on dysregulated pathways and genome-wide changes in HPV-positive oropharyngeal squamous cell carcinoma.