Head and Neck Cancer Studies

Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes.

This study identifies differentially expressed genes and microenvironmental changes in oral epithelial dysplasia using spatial transcriptomics, highlighting potential regulators of malignant transformation.

Oncogenic and immunomodulatory functions of SUV420H1 in HPV-negative head and neck squamous cell carcinoma.

This study identifies SUV420H1 as a driver in HPV-negative HNSCC, showing its role in proliferation, invasion, and immune evasion, and suggests targeting it to improve immunotherapy response.

NOTCH1 Acts as a Tumor Suppressor That Induces Early Differentiation in Head and Neck Cancer

This study clarifies that NOTCH1 acts as a tumor suppressor in head and neck cancer, reducing cancer stem cells and improving prognosis, despite conflicting prior reports.

EMT, angiogenesis, and cell-cycle pathways are significantly impacted in oral cancer patients, among whom a large fraction may potentially respond to immune checkpoint therapy

The paper identifies molecular pathways and immune markers in oral cancer, suggesting potential for immune checkpoint therapy in specific patient subtypes.

Spatial transcriptomics unveils landscape of resistance to concurrent chemo-radiotherapy in hypopharyngeal squamous cell carcinoma: the role of SPP1+ macrophages

This study uses spatial transcriptomics to identify SPP1+ macrophages as key contributors to CCRT resistance in hypopharyngeal SCC by modulating the tumor microenvironment.

Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association

This study uses scRNA-seq to analyze HPV-related multiphenotypic sinonasal carcinoma and finds an association between HPV and MYB expression, with potential prognostic implications.

HPV integration in head and neck cancer: downstream splicing events and expression ratios linked with poor outcomes

This study examines HPV integration in HNSCC using RNA-seq data to link splicing events and expression ratios to poor clinical outcomes.

Naltrexone has variable and schedule-dependent effects on oral squamous cell carcinoma cells

This study investigates the effects of naltrexone on oral squamous cell carcinoma cells, finding that it has minimal impact alone but may enhance chemotherapy effectiveness when combined.

Tumor Subtype Classification Tool for HPV-associated Head and Neck Cancers

This paper develops a machine learning classifier to subtype HPV+ HNSCC tumors into IMU or KRT using bulk RNA-seq data and validates its accuracy across multiple cohorts.

Cross-ancestral GWAS identifies 29 novel variants across Head and Neck Cancer subsites

This study conducts a cross-ancestral GWAS and fine mapping of head and neck squamous cell carcinoma subsites, identifying 29 novel variants and highlighting gene-environment interactions.

Analysis of Head and Neck Cancer scRNA-seq Data Identified PRDM6 Promotes Tumor Progression by Modulating Immune Gene Expression

The paper identifies PRDM6 as a promoter of tumor progression in HNSCC by modulating immune gene expression using scRNA-seq data and IRIS3 analysis.

The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity

This paper shows that Dasatinib and glucocorticoids work together to kill tongue squamous cell carcinoma cells by reducing MET kinase activity and inducing cell cycle arrest and senescence.

A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

This paper develops a machine learning model to predict radiosensitivity in nasopharyngeal carcinoma using gene expression data and validates its association with immune characteristics and signaling pathways.

Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma

This study identifies molecular differences between HPV-associated and HPV-independent SNSCC, showing HPV drives tumorigenesis and suggesting YAP/TAZ and PI3K inhibition as therapeutic targets.

Analysis of Divergent Gene Expression between HPV+ and HPV- Head and Neck Squamous Cell Carcinoma Patients

This study compares gene expression profiles between HPV+ and HPV- HNSCC using RNA-seq data from the PanCancer Atlas 2018, identifying distinct molecular features associated with HPV status.

Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma

This study establishes patient-derived tumor organoids (PDOs) from 31 HNSCC patients, faithfully recapitulating tumor characteristics and predicting cisplatin responses, revealing hEMT-driven resistance and AREG as a therapeutic target.

Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer

This study shows cigarette smoke exposure drives aggressive head and neck cancer by altering oxidative stress response and immunity through Nrf2 activation and metabolic reprogramming.

Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability

This study identifies molecular traits distinguishing HPV+ oropharyngeal cancer recurrence, showing reduced genomic instability contributes to tumor progression and immune suppression.

Large-Scale Whole-Exome Sequencing Association Study Implicates Genetic Effects on Viral Oncogenesis and Tumor Microenvironment in Nasopharyngeal Carcinoma

This study identifies three novel germline variants associated with nasopharyngeal carcinoma risk and introduces a refined polygenic risk score linked to EBV infection.

Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Cancers Identifies KMT2C as a Potential Tumor Suppressor

The paper analyzes the mutational profile of hypopharyngeal and laryngeal cancers, identifying KMT2C as a potential tumor suppressor through in vitro experiments.

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

This study uses Mendelian randomization to assess the causal effect of sexual behavior on oropharyngeal cancer risk, finding attenuated associations after adjusting for confounders.

HPV detection and genotyping of FFPE head and neck cancer biopsies by molecular testing to address new oropharyngeal squamous cell carcinoma classification based on HPV status

This study compares two HPV detection assays on FFPE head and neck cancer biopsies, finding good agreement with some discrepancies due to low viral load.

Distinct co-expression networks using multi-omic data reveal novel interventional targets in HPV-positive and negative head-and-neck squamous cell cancer

This study identifies distinct co-expression networks in HPV+ and HPV- HNSCC using multi-omic data, revealing novel therapeutic targets and regulatory mechanisms.

Molecular Mechanisms Of Human Papillomavirus-Related Carcinogenesis In Head And Neck Cancer

This review explores the molecular mechanisms of HPV-related carcinogenesis in head and neck cancer, focusing on dysregulated pathways and genome-wide changes in HPV-positive oropharyngeal squamous cell carcinoma.