Cellular Mechanics and Interactions

The paper shows that Dlg1 in flanking cells is essential for epithelial invagination by enabling mechanical coordination during apical constriction.

The paper shows that myosin contractility is critical for early mesoderm invagination but not for the folding step, suggesting mechanical bistability in Drosophila gastrulation.

The paper identifies dynamic cell surface fluctuations as a key factor in early embryonic lineage sorting, showing that increased surface fluctuations in primitive endoderm precursors drive their segregation from epiblast precursors.

The paper shows that degenerating larval epidermal cells generate pull forces that drive thorax closure in Drosophila by contracting and shrinking, facilitating HE migration and zipping.

The paper identifies how the zebrafish posterior lateral line primordium generates forward motion by exerting high stresses at its rear through actin flow coupled to the basement membrane via integrins.

The paper shows that mechanical forces from adjacent eye tissue guide neuronal migration and axon extension in zebrafish olfactory placode development.

The paper shows that hyaluronate pressure, driven by local secretion and anisotropic tissue stiffness, shapes zebrafish semicircular canals without actomyosin contractility.

The paper uses computational modeling and experiments to show that polarized supracellular organization in cardiopharyngeal progenitor cell pairs enhances their migratory persistence and mechanical interactions during morphogenesis.

The paper identifies calcium waves in Drosophila interommatidial cells that coordinate actin stress fiber contraction, contributing to retinal floor morphogenesis.

This study identifies Plexin-B2 as a regulator of cell mechanics during multicellular organization, showing its role in modulating cell stiffness, contractility, and differentiation in human stem and progenitor cells.

The paper identifies conserved adhesion genes involved in glioblastoma invasion by screening Drosophila border cell migration and analyzing their expression in human glioblastoma tumors.

The paper develops a model showing how dynamic self-reinforcement of gene expression leads to cellular mechanical memory, linking mechanical history to long-term phenotypic changes.

The paper shows that mechanical competition influences cell behavior during Drosophila gastrulation, with stretching cells exhibiting non-linear mechanical properties despite sharing the same genetic program as constricting neighbors.

This study identifies the genomic signatures of the unjamming transition in human bronchial epithelial cells using mechanical compression and RNA-Seq.

This paper uses optogenetics to manipulate Rho1 signaling in Drosophila embryos, showing how changes in myosin patterns affect cell behaviors and tissue shape during convergent extension.

This paper investigates how 3D viscoelastic drag forces from tailbud tissue drive cell shape changes in the zebrafish embryo's Kupffer's Vesicle during organogenesis.

This study reports viscoelastic maps of the hippocampus in APP/PS1 Alzheimer's disease mice, showing increased stiffness and viscous dissipation compared to wild-type mice.

The paper explores how cellular rearrangements affect viscoelasticity and jamming state transitions in collective cell migration, identifying five viscoelastic states across three regimes.

The paper characterizes Jbug isoforms in Drosophila, showing their differential expression, maternal contribution, and specific roles in actin structures and Crumbs localization.

The paper shows how cell fate-specific changes in osmotic and actomyosin forces coordinate robust organoid morphogenesis through lumen volume reduction and mechanical tension.

The paper investigates epithelial morphogenesis in mouse embryonic salivary glands, finding that budding is driven by strong cell-matrix adhesion and weak cell-cell adhesion in peripheral epithelial cells.

The paper investigates how patterned cell shape changes during Drosophila embryogenesis are regulated by transcription factors and actomyosin gradients to promote tissue curvature.

The paper shows CYK-1/Formin activation in RhoA foci generates active torque in the actomyosin cortex, driving chiral counter-rotation and left-right symmetry breaking in C. elegans embryos.

The paper shows that the geometry of the hindbrain neuropore in mouse embryos determines asymmetric closure dynamics through cell-mediated mechanisms.

The paper shows fluid flow-induced shear stress drives biased epithelial tube elongation in lung and kidney development, independent of other factors.

This study examines how 3D extracellular matrix scaffolds affect the transcriptome of hepatoma cells, aiming to understand their growth and differentiation potential in 3D cultures.

This study identifies MT- and Rab11-dependent trafficking as essential for apical constriction during Drosophila salivary gland invagination by regulating actomyosin networks and cell junctions.

The paper investigates how tissue-scale patterns of cell shape and mechanical stress emerge in Drosophila wing imaginal discs through self-organized mechanosensitive feedback.

The paper models axon bundle migration in response to rigidity gradients using optic ray theory, showing behavior analogous to Snell's law and demonstrating guidance by stiffness variations.

The paper investigates cytoplasmic transport during Drosophila oogenesis, finding that hydraulic forces, not myosin-II contractility, primarily drive the process.