Lipid Membrane Structure and Behavior

Lipid Bilayer Membranes with Asymmetrically Distributed LPC and DAG

This study uses molecular dynamics simulations to show that lipid asymmetry, specifically LPC and PIP2 conversion, affects membrane structure and curvature.

Structural Determinants for the Monomeric and Phospholipid-Transport P4B-ATPase via comprehensive in silico analysis of P4-ATPase structures.

This study identifies structural determinants of P4B-ATPases through in silico analysis, revealing unique features that may underlie their monomeric phospholipid transport mechanism.

Impact of viral membrane oxidation on SARS-CoV-2 spike protein transmembrane anchoring stability

This study uses molecular dynamics simulations to show that partial oxidation of viral membrane lipids reduces SARS-CoV-2 spike protein anchoring stability, with full oxidation lowering the anchoring free energy by 23%.

Light-controlled membrane remodeling in gel-fluid phase-separated giant vesicles using photoswitchable lipids

This study uses photoswitchable lipids to control membrane remodeling in giant vesicles, showing how domain architecture influences light-induced mechanical responses.

Fluorescent peptides for membrane tension and domain structure reporting

This paper introduces fluorescent peptide probes based on GsMTx4 to measure two-dimensional membrane tension and domain structure in biological membranes.

Martini 3 coarse-grained models of azobenzene-based photolipids: Modulation of membranes with light

The paper presents Martini 3 coarse-grained models for azobenzene-based photolipids and demonstrates their ability to accurately simulate membrane properties and photocontrol effects.

Bimodal mechanical response of membrane necks: Implications for the nuclear envelope.

This study investigates how membrane neck size responds to pressure gradients, revealing a two-phase behavior with implications for nuclear envelope mechanics and synthetic membrane design.

Membrane-binding domains define REMORIN phylogeny and provide a predicted structural basis for distinctive membrane nano-environments

This study defines REMORIN phylogeny based on C-terminal domains and predicts structural variations in membrane-binding interfaces that may influence their function and membrane organization.

Boxcar Imaging FCS Reveals Membrane Raft Stabilization Kinetics in Antigen-Stimulated Mast Cells

The paper develops Boxcar Imaging Fluorescence Correlation Spectroscopy to measure raft stabilization kinetics in antigen-stimulated mast cells, revealing distinct diffusion dynamics for Lyn, PM, and Syk proteins.

Pressure-distance curves of identical and dissimilar lipid membrane surfaces in water

The paper measures pressure-distance curves between lipid membranes in water, showing similar hydration repulsion between dissimilar phospholipid-glycolipid surfaces and glycolipid-glycolipid surfaces.

Lipid composition effects on the number and size of liposomes formed by the inverted emulsion method

This study investigates how lipid composition affects liposome production yield and size distribution using the inverted emulsion method.

MAASTY: A (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs

The paper introduces MAASTY, a copolymer for extracting membrane proteins into native nanodiscs, enabling high-resolution structural analysis with cryo-EM while preserving lipids.

Surface morphometrics reveals local membrane thickness variation in organellar subcompartments

The paper uses cryo-ET and a Surface Morphometrics pipeline to measure membrane thickness in organellar subcompartments, revealing variations and correlations with structural features.

Mitochondria-Targeted Peptides and Bilayer Composition Modulate Membrane Electro-poration Under Elevated Electrochemical Stress

The paper uses MD simulations to show that cardiolipin and a mitochondria-targeted peptide reduce electroporation risk by altering membrane capacitance and electrostatics under electrochemical stress.

A Versatile GPMV-Imaging Platform for Quantitative Analysis of Receptor Binding and Membrane Fusion

The paper introduces a GPMV-imaging platform to study receptor binding and membrane fusion in live cells, showing how membrane composition affects fusion efficiency.

Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2

This study shows that PI(4,5)P2 transbilayer asymmetry facilitates FGF2 unconventional secretion by enabling membrane pore formation and GPC1-mediated translocation.

Acylation of the RTX Toxin MbxA stimulates host membrane disruption through a specific interaction with cholesterol

This study investigates how acylation of the RTX toxin MbxA enhances membrane disruption by interacting with cholesterol, showing acylation promotes pore formation but not initial membrane binding.

Anionic Lipid Trafficking and Cell Mechanics RegulateMembrane Electrical Potential in Non-Excitable Tissue Cells

This study shows that non-excitable cells have spatially varying membrane potentials linked to anionic lipid distribution and mechanical factors, challenging the traditional view of membrane potential regulation.

Lipid-Driven Alignment and Binding of p7 Dimers in Early Oligomer Assembly

This study uses molecular dynamics simulations to show that lipid interactions drive the alignment and binding of p7 dimers during oligomer assembly.

Structural Heterogeneity of the Membrane-Interacting Region of the HIV-1 Envelope Glycoprotein

This study investigates the structural dynamics of the HIV-1 gp41 membrane-interacting domain using molecular dynamics simulations and AI-based analysis, revealing diverse conformations of MPER-TMD and interactions with PIP2.

Optimizing the membrane composition of immobilized giant vesicles for effective entrapment and observation of motile bacteria

This study optimizes giant vesicle membrane composition to efficiently entrap motile bacteria, finding that membrane rigidity and DOPS concentration significantly affect entrapment success.

Csf1, a tunnel-like lipid-transfer protein, mediates lipid remodeling and underpins eukaryotic membrane resilience to high hydrostatic pressure and cold

This study identifies Csf1 as a lipid-transfer protein that enables yeast to adapt to high pressure and cold by maintaining membrane lipid unsaturation.

MembraneBuilder: High-speed membrane construction for large molecular dynamics simulations

MembraneBuilder accelerates membrane construction for molecular dynamics simulations by simplifying lipid insertion, enabling faster and larger system generation.

Biomolecular Condensates can Induce Local Membrane Potentials

The paper shows that biomolecular condensates can induce local membrane potentials in Giant Unilamellar Vesicles, with effects influenced by salt concentration and ATP-to-poly-lysine ratios.

TORC2-regulated sterol redistribution mediates recovery from membrane perturbation by small amphipathic molecules.

The paper shows that TORC2 regulates sterol redistribution to recover from membrane perturbation by small amphipathic molecules in yeast and mammalian cells.

Mechanism of Phosphatidylserine Lipid Scrambling by Human SERINC3, an HIV-1Restriction Factor

This study investigates the mechanism of phosphatidylserine scrambling by hSERINC3 using simulations, revealing a novel 'credit card' mechanism distinct from classical models.

Combining Nanoscale Curvature and Polymer Osmotic Pressure for Efficient Giant Vesicle Assembly under Physiological Conditions

This paper introduces a method using polymer-coated nanocellulose paper to efficiently assemble giant unilamellar vesicles under physiological conditions.

Sphingolipid-driven interleaflet coupling orchestrates Rho-GTPase recruitment to nanodomains for signal activation in plants

The paper shows sphingolipid-driven interleaflet coupling organizes nanodomains and activates Rho-GTPase in plants, linking membrane asymmetry to signaling.

Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes

The paper investigates how membrane lipid homeostasis mechanisms adapt to species-specific lipid compositions in fission yeasts using lipidomics and transcriptomics.

Optimizing Coarse-Grained Models for Large-Scale Membrane Protein Simulation

This paper optimizes a coarse-grained lipid model for large-scale membrane protein simulations and demonstrates its application to study PIEZO-induced membrane deformation.