Nerve injury and regeneration

This study delivers hyper-IL-6 to spinal cord neurons using retrograde AAV, activating Stat3 but causing severe tremors and weight loss in mice.

This study evaluates motoneuronal regeneration and Wallerian degeneration after sciatic nerve injury at different postnatal stages in mice, finding that regenerative capacity is linked to intrinsic growth state rather than age.

This study identifies a signaling cascade involving IDR-1 and RBM-42 that promotes dendrite regeneration through RNA-binding protein nuclear export and local translation.

The paper compares the spatiotemporal dynamics of TrkA, TrkB, and TrkC using biosensors, finding distinct signaling and trafficking behaviors, particularly for TrkC isoforms.

This paper identifies a small molecule DM04 that mimics retinoic acid's effects on axon growth and motor recovery after spinal cord injury, acting through a non-canonical mechanism.

This study shows that acetylation of G3BP1 by ELP3 promotes axon regeneration and neuronal recovery after injury.

This study identifies CASPR as a novel 'eat-me' signal promoting axonal debris clearance by Schwann cells and macrophages after peripheral nerve injury.

This paper develops a human iPSC-derived motor neuron-myogenic coculture platform to study NMJ innervation after axon injury and in SMA, showing blebbistatin enhances NMJ reinnervation and confirming reduced NMJ function in SMA patient-derived neurons.

The paper shows that axonal mTOR-dependent Rab5 translation is essential for BDNF signaling and retrograde transport to the nucleus.

This study identifies the intracellular domain of LIFR/CD118 as essential for optic nerve regeneration in mature RGCs, independent of LIF and other therapies.

This study shows that ApoE2 overexpression via AAV improves axon regeneration and motor function after spinal cord injury through LRP8 signaling without affecting inflammation or scarring.

This study identifies Mena as a regulator of local protein synthesis in adult axons, showing it controls PI3K-p85 mRNA translation and axon regeneration after injury.

This paper develops a genetic screening platform in Drosophila to identify regulators of axon degeneration by depleting dNmnat, revealing new factors that influence neuronal survival and NAD+ homeostasis.

This study shows that Drosophila tonic motor neurons can reinnervate denervated muscles through structural plasticity, while phasic neurons show minimal remodeling.

This study shows that glutathione-coated Ni(OH)2 nanoparticles form complexes with NGL-1, promoting axon regeneration in Alzheimer's and spinal cord-injured mice under near-infrared light.

This study shows that inhibiting Clarinet/CLA-1 in C. elegans enhances axon regeneration without affecting synapse reformation, suggesting a potential therapeutic target for nerve repair.

This study evaluates RETS nerve transfer in a delayed rat nerve injury model, finding inferior donor nerve regeneration but successful NMJ formation, and highlights the role of regeneration tracks in repair outcomes.

AxoMetric quantifies axon regeneration in tissue sections with speed and accuracy, matching manual methods while enabling high-throughput analysis.

This study uses organotypic slice cultures to show that optogenetic activation of entorhinal neurons does not enhance axon regeneration after injury but alters target recognition and circuit development.

This study identifies NR2F1 and NR2F6 as nuclear receptor transcription factors that promote axon regeneration in the corticospinal tract through chromatin remodeling, enhancer redeployment, and translational reprogramming.

This study maps chromatin accessibility changes in mouse forebrain development and shows that PATZ1 can reverse epigenetic restrictions in adult neurons to enhance axon regeneration after injury.

This study investigates the combined effects of db-cAMP and integrin 9 overexpression on axonal regeneration in spinal cord injury models, finding mixed in vitro and in vivo results.

This paper identifies a signaling pathway in the mouse retina involving Kv2.1, GLT-1, and NOS1 that promotes optic nerve regeneration after injury.

The paper designs TrkA agonists that activate neuronal differentiation and neurite outgrowth without triggering pain-related gene expression.

This study shows that retinal ganglion cell regenerative potential is linked to their developmental maturation timeline, with sON cells showing greater injury-induced regression than tON cells.

This study shows that loss of Sarm1 reduces axonal degeneration and promotes neuronal repair after ischemic stroke by activating a pro-growth molecular program.

This study identifies HIFN, a novel TrkB activator, which improves visual function and retinal neuron survival in a mouse model of ocular trauma.

The paper identifies metabolic reprogramming in zebrafish axonal regeneration and shows its conservation in mammals, suggesting therapeutic potential for CNS regeneration.

The paper investigates the role of lipid metabolism in axon maintenance and regeneration in C. elegans, showing that DIP-2 counterbalances phospholipid synthesis to prevent age-related axonal defects.