Stress Responses and Cortisol

Changing environments reveal innovative genetic variation in children's cortisol responses

The paper shows that environmental changes reveal new genetic influences on cortisol responses in children, challenging the idea that genetic variation only codes for fixed phenotypes.

Ovarian hormone status dictates the neuroinflammatory and behavioural consequences of sub-chronic stress exposure in middle-aged female mice

This study shows that long-term ovariectomy alters neuroinflammatory responses and behavioral outcomes to sub-chronic stress in middle-aged mice, highlighting the role of ovarian hormones in stress-related disorders.

Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

This study shows that early life stress alters transcriptomic patterns in reward circuitry of male and female mice, increasing sensitivity to adult stress.

Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques

This study shows that social status affects gene expression in immune cells of rhesus macaques, with effects modulated by pathogen exposure, type, and social history.

Role of CRF receptor 1 antagonism in the bed nucleus of the stria terminalis of male rats after intermittent social defeat stress

This study investigates the role of CRFR1 antagonism in the BNST of male rats after social defeat stress, finding that low-dose CRFR1 antagonism restores social behavior while high-dose induces social avoidance.

Social Instability is an Effective Chronic Stress Paradigm for both Male and Female Mice

This paper introduces a social stress paradigm, social instability stress (SIS), that induces chronic stress in both male and female mice, with effects reversible by antidepressants.

Chronic paroxetine blunts stress response and normalizes adverse behavioral effects seen acutely in nulliparous rats

This study shows chronic paroxetine reduces stress-induced corticosterone and normalizes behavioral effects in nulliparous rats, unlike acute treatment.

Impact of mothers’ past experience and early-life stress on aggression and cognition in adult male mice

This study investigates how mothers' past stress and early-life stress affect aggression and cognition in adult male mice, finding that combined stress leads to increased aggression and improved spatial memory.

Selective modulation of the glucocorticoid receptor with CORT108297 during chronic adolescent stress evokes sex specific effects in adulthood.

This study examines how adolescent chronic stress affects behavior and physiology differently in male and female rats, with GR signaling playing a role in some outcomes.

The behavioral phenotype of early life adversity: a 3-level meta-analysis of rodent studies

This study conducts a 3-level meta-analysis of rodent studies to assess how early life adversity affects behavioral domains, finding differential impacts on memory, anxiety, and social behavior.

Sex differences in chronic social stress models in mice

This study introduces a female mouse model of chronic social stress and a modified male model to investigate sex differences in stress response and long-term consequences.

Sex and Estrous Cycle Effects on Anxiety- and Depression-related Phenotypes in Two-hit Developmental Stress Model

This study investigates sex and estrous cycle effects on anxiety- and depression-related phenotypes in a two-hit developmental stress model, finding sex-specific impacts of early-life and adolescent stress.

Stress-induced neuronal hypertrophy decreases the intrinsic excitability in stress habituation

The paper shows that repeated stress reduces intrinsic excitability of HPA axis neurons through increased cell size and membrane area, challenging conventional views on excitability plasticity.

Corticotropin-Releasing Hormone Signaling in the Oval Bed Nucleus of the Stria Terminalis Mediates Chronic Stress-Induced Negative Valence Behaviors Associated with Anxiety

This study investigates how chronic stress affects CRH signaling and neuronal activity in the BNST, linking these changes to anxiety-related behaviors in mice.

Chronic unpredictable stress promotes cell-specific plasticity in prefrontal cortex D1 and D2 pyramidal neurons

This study shows that chronic unpredictable stress causes distinct plasticity in D1 and D2 pyramidal neurons in the prefrontal cortex, affecting their excitability and synaptic transmission.

Bioinformatic analysis of long-lasting transcriptional and translational changes in the basolateral amygdala following acute stress

This study identifies long-lasting transcriptional and translational changes in the basolateral amygdala after a single acute stress event using integrative genomic and proteomic approaches.

Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques

This study shows that social status affects chromatin accessibility and gene regulation in response to glucocorticoids in rhesus macaques, with stable effects on chromatin accessibility and reduced gene expression effects after treatment.

Computational psychiatry 2.0 and implications for stress research

This paper explores computational psychiatry 2.0, emphasizing the integration of computational models with stress research and brain-gut interactions to better understand stress-related disorders.

Predator odor increases glutamatergic synaptic transmission in the prelimbic cortex via corticotropin-releasing factor receptor 1 signaling

The paper was retracted due to research misconduct, making its results and conclusions unreliable.

Elimination of vesicular zinc alters the behavioural and neuroanatomical effects of social defeat stress in mice

This study investigates how the absence of vesicular zinc affects stress resilience in mice, finding mixed outcomes in social behavior and fear memory.

Stress-induced alterations of norepinephrine release in the bed nucleus of the stria terminalis of mice

The paper examines how repeated stress affects norepinephrine release in the BNST of mice, finding increased release and reduced autoreceptor sensitivity.

Locomotor response to acute stressors requires hypothalamic-pituitary-interrenal axis activation and glucocorticoid receptor

The paper shows that zebrafish locomotor response to acute stressors requires HPI axis activation via mc2r and nr3c1, but not nr3c2.

Aberrant expression of collagen family genes in the brain regions developing under agonistic interactions in male mice

The paper examines collagen gene expression changes in brain regions of male mice after 20 days of agonistic interactions, finding upregulation in some areas and downregulation in others.

Immediate effects of psychosocial stress on attention depend on subjective experience and not directly on stress-related physiological changes

This study shows that acute psychosocial stress affects attention based on subjective experience rather than direct physiological changes.

Sensory Detection of Aversive and Appetitive Stimuli by CRF neurons

The paper shows that PVN CRF neurons respond rapidly to aversive and appetitive stimuli in mice, suggesting their role in sensory detection and neuroendocrine regulation.