Stress Responses and Cortisol

Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress

This study shows that reducing glutamate output in the infralimbic cortex of rats alters neural activity and behavior after chronic stress, highlighting its role in stress-related disorders.

RL-118 and 11β-HSD1 target engagement through TAPS assay: behaviour and molecular analysis

This study investigates the effects of RL-118, an 11β-HSD1 inhibitor, on cognitive and molecular changes induced by chronic mild stress in SAMP8 mice, showing restoration of stress-induced impairments.

What it takes to be at the top: The interrelationship between chronic social stress and social dominance

The paper investigates how chronic social stress affects social dominance and vulnerability in mice, finding that stress susceptibility does not prevent dominance but impacts social behavior in both high- and low-status mice.

Post-weaning social isolation increases ΔFosB/FosB protein expression in the prefrontal cortex and hippocampus in mice

From stress to depression: Development of extracellular matrix-dependent cognitive impairment following social stress

This study investigates how social stress leads to cognitive impairment and affective disturbances in rats, revealing distinct phases of hippocampal extracellular matrix remodeling associated with different aspects of depression.

Sex differences in cortisol and memory following acute social stress in amnestic mild cognitive impairment

Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adults

This study identifies age- and sex-specific mitochondrial and proteomic adaptations in the hippocampus and liver following early-life stress in mice.

Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABA-ergic Parvalbuminpositive Interneurons Attenuates Chronic Stress Adaptions in Male Mice

This study inhibits prefrontal cortex parvalbumin interneurons in mice using DREADDs and shows that it reduces chronic stress-related behaviors and physiological changes.

Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood

The paper investigates the long-term effects of chronic cortisol exposure during zebrafish embryonic development, finding persistent neuroendocrine dysregulation and altered gene expression in adulthood.

Social isolation stress in adolescence, but not adulthood, produces hypersocial behavior in adult male and female C57BL/6J mice

This study shows that adolescent social isolation in mice leads to hypersocial and female-specific anxiolytic behaviors, while adult social isolation only increases anxiety in the light/dark box.

Validation of chronic restraint stress model in rats for the study of depression using longitudinal multimodal MR imaging

This study validates a chronic restraint stress model in rats for depression research using longitudinal MRI and behavioral tests, finding brain connectivity, neurometabolite, and structural changes linked to depression-like behaviors.

Molecular characterization of the stress network in the human brain

The paper identifies 201 differentially expressed genes in stress-sensitive brain regions linked to psychiatric disorders and potential drug targets.

Prelimbic-amygdala overexcitability mediates trait vulnerability in a novel mouse model of acute social defeat stress

This study identifies preexisting structural and functional differences in the prelimbic-amygdala circuit that mediate vulnerability to acute social defeat stress in male mice.

Chronic stress exacerbates acute stress-induced neuronal activation in the anterior cingulate cortex and ventral hippocampus that correlates with behavioral deficits in mice

This study shows that chronic stress increases neuronal activation in specific brain regions in response to acute stress, which correlates with behavioral deficits in mice.

Making Good Choices: Social Interaction in Mice Mitigates Chronic Stress-Induced Adaptive Changes in Decision Making

This study shows that social interaction reduces chronic stress-induced increases in high-risk decision-making in mice.

Prenatal psychosocial stress-induced behavioral and neuroendocrine abnormalities are associated with sex-specific alterations in synaptic transmission and differentially modulated by maternal environment

This study shows prenatal stress causes sex-specific behavioral and neuroendocrine issues in mice, with maternal care reversing some effects.

Regularity extraction under stress: boosted statistical learning but unaffected sequence learning

This study investigates how stress affects the acquisition of statistical and sequential regularities, finding stress enhances statistical learning but not sequential learning.

Traumatic stress history interacts with chronic peripheral inflammation to alter mitochondrial function of synaptosomes in a sex-specific manner

This study investigates how chronic stress and inflammation interact to affect mitochondrial function in synaptosomes, showing sex-specific differences in behavioral and metabolic outcomes.

Elevated plasma cortisol associated with larger ventricles and smaller hippocampal volumes, a study in 2 independent elderly cohorts

The paper investigates the association between elevated plasma cortisol and brain volume changes in elderly cohorts, finding larger ventricles and smaller hippocampal volumes.

Adaptive synaptic plasticity maintains CRH neuron output during chronic glucocorticoid exposure

The paper shows CRH neurons adapt to chronic glucocorticoid exposure by increasing synaptic strength to maintain output stability.

Maturation of lateral habenula and early-life experience-dependent alteration with behavioral disorders in adulthood

This study shows that early-life stress during a specific developmental window disrupts LHb maturation, leading to anxiety/depression-like behaviors in adulthood.

Role of enhanced glucocorticoid receptor sensitivity in inflammation in PTSD: Insights from a computational model for circadian-neuroendocrine-immune interactions

The paper develops a computational model to explore how increased glucocorticoid receptor sensitivity in PTSD contributes to inflammation through HPA-axis and immune system interactions.

Early-life adversity is associated with differential gene expression in response to acute psychological stress: preliminary findings

The paper examines how early-life adversity affects gene expression and physiological responses to acute stress in young adults, finding higher cortisol and lower NR3C1 expression in the ELA group.

Ras-GRF1 in CRF Cells Controls the Early Adolescent Female Response to Repeated Stress

This study shows that GRF1 in CRF cells of the hypothalamus influences the stress response in early adolescent female mice, reducing CORT levels and anxiolytic effects after repeated stress.

Associations of waking cortisol with DHEA and testosterone across the pubertal transition: Effects of threat-related early life stress

The paper examines how threat-related early life stress affects the relationship between cortisol, DHEA, and testosterone during puberty using longitudinal data from adolescents.

Regulation of neuron-specific gene transcription by stress hormone signalling requires synaptic activity in zebrafish

This study identifies two distinct GR-regulated transcription pathways in zebrafish brains, showing synaptic activity's role in GR-mediated transcription of aplp1.

Sexually divergent effects of social dominance on chronic stress outcomes in mice

This study shows that in mice, pre-stress social dominance interacts with sex to influence chronic stress outcomes, with males and females showing opposite behavioral responses to stress.

Acute Stress Desensitizes Hypothalamic CRH Neurons to Norepinephrine and Physiological Stress

The paper shows that acute stress reduces the response of CRH neurons to norepinephrine and physiological stress through glucocorticoid-mediated adrenoreceptor desensitization.

Chronic corticosterone administration induces negative valence and impairs positive valence behaviors in mice

This study shows chronic corticosterone administration in mice increases anxiety-like behaviors and impairs reward-related behaviors, suggesting it models stress-induced mood disorders.

Selective activation of estrogen receptors α and β: Implications for depressive-like phenotypes in female mice exposed to chronic unpredictable stress

This study investigates how estrogen receptor α and β activation affects depressive-like behaviors in female mice under chronic stress and non-stress conditions.