Cellular transport and secretion

This study identifies a congenital disorder of glycosylation caused by a missense variant in the second starting methionine of syntaxin-5, leading to loss of the short isoform and multisystem disease.

This study identifies tSNARE1 as a schizophrenia risk gene that regulates endolysosomal trafficking in cortical neurons through its isoforms' effects on endosomal cargo movement.

This study shows N-cadherin modulates endocytosis at physiological temperature by interacting with actin filaments and enhancing vesicle recycling at glutamatergic synapses.

The paper develops a systems biology model to simulate adrenergic stimulation of adiponectin exocytosis in white adipocytes and validates it with experimental data.

The paper shows that the AP-3 complex is required for Vtc5 localization to the vacuole membrane in yeast, and its mislocalization leads to decreased polyP levels.

This study investigates the role of SYT7 in synaptic function by analyzing its localization and effects on vesicle docking and synaptic plasticity in mouse hippocampal neurons.

This study identifies a novel CCK complex involving CLN6, CRMP2, and KLC4 that regulates ER-derived vesicle transport in axons, with implications for neurodegenerative disease therapy.

The paper develops a kinetic model of vesicle fusion transitions that reproduces neuromuscular transmission dynamics, including facilitation and depression.

This study shows that high-fat diet feeding reduces Rab3a, Rab3gap1, and Rab3gap2 gene expression in the hypothalamus, potentially disrupting neuronal exocytosis and receptor recycling.

The paper shows Myosin-1b is essential for intestinal epithelial folding in zebrafish and contributes to villous atrophy when UNC45A is lost.

This study uses smFRET to show that syntaxin-3b's conformational changes regulate SNARE complex assembly in ribbon synapses, with phosphorylation promoting SNARE complex formation.

The paper investigates the conservation and expression of synaptotagmin isoforms in zebrafish retina, identifying their roles in Ca2+-dependent exocytosis.

This study reexamines the roles of Syntaxin-1's N-peptide and Habc-domain in synaptic vesicle fusion using a mouse model, showing the Habc-domain is essential while the N-peptide has regulatory functions.

The paper predicts TMEM106B in humans and Vac7 and Tag1 in yeast as lipid transfer proteins based on structural and sequence analysis.

This study investigates how mutations in the C1C2B region of Munc13-1 affect neurotransmitter release and presynaptic plasticity in murine hippocampal cultures.

This study shows that polybasic patches in both C2A and C2B domains of Synaptotagmin-1 are required for evoked neurotransmitter release, but not for spontaneous release or the readily releasable vesicle pool.

The paper uses molecular dynamics simulations to show that SNAREs and Synaptotagmin work in fixed stoichiometry modules to determine Ca2+ sensitivity of neurotransmitter release.

This study uses simulations to show that Ca2+-triggered unclamping and SNARE-mediated fusion in neurotransmitter release are coupled processes, not sequential steps.

This study identifies MAD2 as a key protein facilitating the internalization of monoamine transporters through interactions with AP2 and SAC proteins.

The paper investigates serotonin release mechanisms from mouse enterochromaffin cells using multiple techniques and finds that serotonin is primarily released from large dense-core vesicles with slow kinetics, similar to other endocrine cells.

The paper shows that 2{delta}-1, but not 2{delta}-3, enhances CaV2.2 membrane expression via Rab11a-dependent recycling, affecting channel localization and function.

This study identifies Rab10 as a regulator of collagen IV secretion through lysyl hydroxylase 3 trafficking, linking Notch signaling to vascular basement membrane formation.

This study shows that myosin V regulates the spatial distribution of neurotransmitter release sites in central synapses, affecting both uni-vesicular and multi-vesicular release.

The paper models endosome maturation using a mathematical framework and applies it to understand Dengue viral escape times from endosomes.

This study shows that synapsin SNN-1 is required for cAMP-dependent neuropeptide release in C. elegans motor neurons by capturing dense core vesicles at synapses.

The paper quantifies Kv4.2 ion channel transport in neurons, revealing higher axonal transport despite dendritic expression, and explains this with mathematical models of intracellular trafficking.

The paper elucidates the structural basis of retromer core trimer assembly with SNX3, showing how it forms tubular carriers and incorporates cargo through conserved interfaces linked to Parkinson's disease mutations.

This study investigates the roles of synaptotagmin-1 and synaptotagmin-7 in Ca2+-dependent vesicle priming and exocytosis in mouse chromaffin cells, showing their synergistic effects.

The paper quantitatively analyzes the kinetic structure of the recycling vesicle pool at the Calyx of Held synapse under physiological conditions, revealing dynamically regulated sub-pools that ensure efficient synaptic transmission.

The paper identifies RAB2's role in presynaptic precursor vesicle biogenesis at the trans-Golgi network, showing its necessity for proper protein transport and neurotransmission.