Advanced Glycation End Products research

HMGB1 B-box domain self-complexes promote protein-polyelectrolyte interactions.

This study shows that HMGB1's B-box domain forms self-associates that enhance interactions with heparin through charge redistribution and conformational changes.

Glo1 reduction in mice results in age- and sex-dependent metabolic dysfunction

This study shows that reducing Glo1 in mice causes age- and sex-dependent metabolic issues like obesity and altered lipid metabolism without significant changes in AGEs.

The molecular basis of Human FN3K mediated phosphorylation of glycated substrate

This study determines crystal structures of HsFN3K to elucidate its substrate recognition and kinase activity, providing insights for small molecule design targeting FN3K.

AGEing of Collagen: The Effects of Glycation on Collagen's Stability, Mechanics and Assembly

This study examines how glycation affects collagen stability, mechanics, and self-assembly, showing reduced triple helical stability, increased stiffness, and impaired fibril formation.

Implications of diabetes mellitus on pathophysiology of Tuberculosis: Role of AGE-RAGE Axis and Glycated Proteins

This study examines how diabetes-induced AGEs and RAGE contribute to immune dysfunction and worsen tuberculosis severity in comorbid patients.

Increased levels of circulating methylglyoxal have no consequence for cerebral microvascular integrity and cognitive function in young healthy mice

This study shows increased circulating methylglyoxal in healthy mice does not cause cerebral microvascular dysfunction or cognitive impairment.

Glycaemia and albumin glycation rates as fitness mediators in the wild: the case of a long-lived bird

The paper examines how plasma glucose and albumin glycation rates relate to age and fitness in Alpine swifts, finding age-related changes and links to reproductive success and survival.

Study on the influence of G82S RAGE polymorphism on RAGE-Amyloid interaction in AD pathology

This study investigates how the G82S RAGE polymorphism affects RAGE-Amyloid interaction in AD by using molecular dynamics and in vitro binding experiments, finding that the mutant has higher binding affinity for Aβ42.

Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

This study shows that phosphorylation of threonine 107 in Glo1 by CamKIIδ increases its catalytic efficiency and reduces proteasomal degradation, enhancing MG detoxification.

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion.

This study shows that increasing OST48 expression in diabetic mice improves insulin secretion but does not prevent diabetic kidney disease despite enhancing AGE clearance.

Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue

The paper identifies a nuclear RAGE isoform in kidney tissue that binds to its own gene promoter, suggesting self-regulation of RAGE expression, which is altered in obesity and kidney disease.