Advanced Glycation End Products research

Decoupling glycation from mortality: glucose, but not methylglyoxal, reduces survival in zebra finches

This study shows glucose, but not methylglyoxal, reduces survival in zebra finches, with increased mortality and albumin glycation observed in glucose-supplemented birds.

Thermodynamic properties and stability of HMGB1 complexes with linear polyelectrolytes elucidated by nano differential scanning fluorimetry

This study uses nanoDSF, CD, and DLS to analyze the stability and interaction behavior of HMGB1 with heparin and lPGS.

Glyoxal induces DNA-Protein Crosslinking in Cells

This study shows glyoxal induces DNA-protein crosslinks in human cells, with SPRTN playing a role in repair and 469 proteins showing increased DNA association.

Galangin and Caffeic acid inhibit Methylglyoxal-induced Advanced Glycation End Product formation in Bovine Serum Albumin

This paper investigates the antiglycation effects of Galangin and Caffeic acid on Methylglyoxal-induced Advanced Glycation End Products in Bovine Serum Albumin.

Contrasting effects of glucose and methylglyoxal supplementation on blood oxidative status, blood cells' telomere dynamics and apoptosis in birds

This study investigates the effects of glucose and methylglyoxal on oxidative stress, telomere dynamics, and apoptosis in zebra finches, finding distinct impacts on health and aging.

Detrimental effects of advanced glycation end-products (AGEs) on a human neuromuscular junction co-culture model

This study examines the effects of AGEs on a human neuromuscular junction co-culture model, revealing structural, metabolic, and functional impairments.

Antiglycation effects of imidazole dipeptides and 2-oxo-imidazole dipeptides on glyceraldehyde-induced intracellular protein glycation and neuronal cell death

This study evaluates the antiglycation effects of imidazole dipeptides and 2-oxo-imidazole dipeptides against glyceraldehyde-induced protein glycation and neuronal cell death, showing that carnosine and balenine are most effective.

Hmgb1 release kinetics shape its extracellular functions during regulated cell death

The paper investigates Hmgb1 release kinetics during regulated cell death and shows that rapid release generates higher local concentrations, influencing its extracellular functions.

Organic Germanium (Ge-132) reduces glycative damage while maintaining cellular stress signaling: evidence of functional dissociation

This study investigates the effects of organic germanium (Ge-132) on glycative damage and cellular stress signaling, finding a dissociation between reduced glycative damage and stress response pathways.

Effects and Mechanisms of Aerobic Exercise on Myocardial AGEs/RAGE-p38 MAPK-NF-κB Pathway in SHR Rats

This study examines how aerobic exercise affects blood pressure, cardiac function, and the AGEs/RAGE-p38 MAPK-NF-κB pathway in SHR rats, finding that exercise reduces blood pressure and cardiac damage by inhibiting this pathway.

The Role of the Receptor for Advanced Glycation End-Products in Cancer: Evidence from a Systematic Review and Meta-Analysis

This study conducts a systematic review and meta-analysis to assess the role of RAGE in cancer, finding it correlates with cancer progression and poor patient survival.

Pathological stiffening by crosslinking glycation of titin

This study shows that glycation of cardiac titin increases in diabetes, leading to protein and cardiomyocyte stiffening through crosslinking advanced glycation end products.

Tannic acid fortifies extracellular matrix against dicarbonyl stress

This study shows tannic acid protects extracellular matrix from methylglyoxal-induced damage by stabilizing its biochemical properties and restoring cell adhesion.

Fructose utilization by GM-CSF-differentiated macrophages aggravates autoimmune inflammation via MG-derived AGE-RAGE signaling

This study shows fructose metabolism in GM-CSF-differentiated macrophages promotes autoimmune inflammation through MG-AGE-RAGE signaling by enhancing glycolysis and Th17 differentiation.

Consumption of processed foods impairs memory function through dietary advanced glycation end-products

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.

Mechanistic Link Between Glyoxalase 1 Expression and Methylglyoxal-Induced Oncogenic Stress in Prostate Cancer

This study links elevated methylglyoxal-adducts and GLO1 genetic variants in African American/Black men with prostate cancer progression through metabolic reprogramming and impaired detoxification.

C2-α-dicarbonyls selectively impair morphodynamic interactions between cells and extracellular matrix

This study examines how three dicarbonyls affect extracellular matrix interactions with human cells, revealing distinct impacts on matrix structure and cellular behavior.

A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-Product

This study identifies a cyclic arginine adduct as the primary glyoxal-derived AGE, challenging prior assumptions about lysine modification and highlighting experimental condition impacts.

HMGB1 B-box domain self-complexes promote protein-polyelectrolyte interactions.

This study shows that HMGB1's B-box domain forms self-associates that enhance interactions with heparin through charge redistribution and conformational changes.

Glo1 reduction in mice results in age- and sex-dependent metabolic dysfunction

This study shows that reducing Glo1 in mice causes age- and sex-dependent metabolic issues like obesity and altered lipid metabolism without significant changes in AGEs.

Implications of diabetes mellitus on pathophysiology of Tuberculosis: Role of AGE-RAGE Axis and Glycated Proteins

This study examines how diabetes-induced AGEs and RAGE contribute to immune dysfunction and worsen tuberculosis severity in comorbid patients.

Glycaemia and albumin glycation rates as fitness mediators in the wild: the case of a long-lived bird

The paper examines how plasma glucose and albumin glycation rates relate to age and fitness in Alpine swifts, finding age-related changes and links to reproductive success and survival.

Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

This study shows that phosphorylation of threonine 107 in Glo1 by CamKIIδ increases its catalytic efficiency and reduces proteasomal degradation, enhancing MG detoxification.

Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue

The paper identifies a nuclear RAGE isoform in kidney tissue that binds to its own gene promoter, suggesting self-regulation of RAGE expression, which is altered in obesity and kidney disease.