Advanced Glycation End Products research

Decoupling glycation from mortality: glucose, but not methylglyoxal, reduces survival in zebra finches

This study shows glucose, but not methylglyoxal, reduces survival in zebra finches, with increased mortality and albumin glycation observed in glucose-supplemented birds.

Thermodynamic properties and stability of HMGB1 complexes with linear polyelectrolytes elucidated by nano differential scanning fluorimetry

This study uses nanoDSF, CD, and DLS to analyze the stability and interaction behavior of HMGB1 with heparin and lPGS.

Engineered HMGB1 construct with tandem Box B domains promotes tissue regeneration without potential for deleterious inflammation or thrombosis

Glyoxal induces DNA-Protein Crosslinking in Cells

This study shows glyoxal induces DNA-protein crosslinks in human cells, with SPRTN playing a role in repair and 469 proteins showing increased DNA association.

Galangin and Caffeic acid inhibit Methylglyoxal-induced Advanced Glycation End Product formation in Bovine Serum Albumin

This paper investigates the antiglycation effects of Galangin and Caffeic acid on Methylglyoxal-induced Advanced Glycation End Products in Bovine Serum Albumin.

Contrasting effects of glucose and methylglyoxal supplementation on blood oxidative status, blood cells' telomere dynamics and apoptosis in birds

This study investigates the effects of glucose and methylglyoxal on oxidative stress, telomere dynamics, and apoptosis in zebra finches, finding distinct impacts on health and aging.

Detrimental effects of advanced glycation end-products (AGEs) on a human neuromuscular junction co-culture model

This study examines the effects of AGEs on a human neuromuscular junction co-culture model, revealing structural, metabolic, and functional impairments.

Antiglycation effects of imidazole dipeptides and 2-oxo-imidazole dipeptides on glyceraldehyde-induced intracellular protein glycation and neuronal cell death

This study evaluates the antiglycation effects of imidazole dipeptides and 2-oxo-imidazole dipeptides against glyceraldehyde-induced protein glycation and neuronal cell death, showing that carnosine and balenine are most effective.

Hmgb1 release kinetics shape its extracellular functions during regulated cell death

The paper investigates Hmgb1 release kinetics during regulated cell death and shows that rapid release generates higher local concentrations, influencing its extracellular functions.

Organic Germanium (Ge-132) reduces glycative damage while maintaining cellular stress signaling: evidence of functional dissociation

This study investigates the effects of organic germanium (Ge-132) on glycative damage and cellular stress signaling, finding a dissociation between reduced glycative damage and stress response pathways.

Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation.

This study uses ancestral protein reconstruction to uncover the molecular mechanism of substrate specificity in FN3K and KT3K enzymes, revealing an allosteric network that modulates substrate recognition.

Effects and Mechanisms of Aerobic Exercise on Myocardial AGEs/RAGE-p38 MAPK-NF-κB Pathway in SHR Rats

This study examines how aerobic exercise affects blood pressure, cardiac function, and the AGEs/RAGE-p38 MAPK-NF-κB pathway in SHR rats, finding that exercise reduces blood pressure and cardiac damage by inhibiting this pathway.

The Role of the Receptor for Advanced Glycation End-Products in Cancer: Evidence from a Systematic Review and Meta-Analysis

This study conducts a systematic review and meta-analysis to assess the role of RAGE in cancer, finding it correlates with cancer progression and poor patient survival.

Pathological stiffening by crosslinking glycation of titin

This study shows that glycation of cardiac titin increases in diabetes, leading to protein and cardiomyocyte stiffening through crosslinking advanced glycation end products.

Tannic acid fortifies extracellular matrix against dicarbonyl stress

This study shows tannic acid protects extracellular matrix from methylglyoxal-induced damage by stabilizing its biochemical properties and restoring cell adhesion.

Discovery of Glycation-Derived Crosslinks at Arginine

This study discovers a new type of glycation crosslink, MIDAL, formed by methylglyoxal in Arg-Arg sites, and presents a platform for studying crosslinking AGEs.

Fructose utilization by GM-CSF-differentiated macrophages aggravates autoimmune inflammation via MG-derived AGE-RAGE signaling

This study shows fructose metabolism in GM-CSF-differentiated macrophages promotes autoimmune inflammation through MG-AGE-RAGE signaling by enhancing glycolysis and Th17 differentiation.

Consumption of processed foods impairs memory function through dietary advanced glycation end-products

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.

Dicarbonyl stress debilitates mesothelial defense against metastasizing ovarian cancer

This study shows dicarbonyl stress weakens mesothelial barriers, enabling ovarian cancer metastasis, and identifies GLO-1 as a potential therapeutic target.

Mechanistic Link Between Glyoxalase 1 Expression and Methylglyoxal-Induced Oncogenic Stress in Prostate Cancer

This study links elevated methylglyoxal-adducts and GLO1 genetic variants in African American/Black men with prostate cancer progression through metabolic reprogramming and impaired detoxification.

Methylglyoxal-induced glycation stress promotes aortic stiffening: Putative mechanistic roles of oxidative stress and cellular senescence

This study shows that methylglyoxal-induced glycation stress causes aortic stiffening through oxidative stress and cellular senescence, and a glycation-lowering compound mitigates these effects.

Glycation enhances protein association with lipid bilayer membranes

This study shows glycation increases the binding of bovine serum albumin to negatively charged lipid bilayers, altering protein-membrane interactions and potentially affecting biomarker behavior and disease mechanisms.

Histone serves as an eat-me signal to induce RAGE-mediated phagocytosis

The paper identifies histones as RAGE-mediated eat-me signals that enhance phagocytosis of apoptotic cells and show physiological relevance in wound healing.

A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine

This study identifies a chemical mechanism for argpyrimidine formation from methylglyoxal, showing phosphorylated residues promote APY formation and linking glycation to phosphorylation.

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.

Predictable modulation of a spontaneous post-translational modification in living cells

This paper introduces dialAGE, a method to control site-specific glycation in proteins, showing it works in vitro and in living cells.

C2-α-dicarbonyls selectively impair morphodynamic interactions between cells and extracellular matrix

This study examines how three dicarbonyls affect extracellular matrix interactions with human cells, revealing distinct impacts on matrix structure and cellular behavior.

A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-Product

This study identifies a cyclic arginine adduct as the primary glyoxal-derived AGE, challenging prior assumptions about lysine modification and highlighting experimental condition impacts.

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

This study examines glycation rates and glucose levels across 88 bird species to assess their relationship with life history traits, finding resistance to glycation in high glucose species and unexpected patterns in lifespan and diet.

The sex-specific effects of RAGE signaling and Type 2 Diabetes on mouse cortical bone mechanics, structure, and material properties

This study examines how RAGE signaling and Type 2 Diabetes affect cortical bone mechanics, structure, and material properties in mice, showing sex-specific improvements with RAGE ablation.