Respiratory viral infections research

Virion stripping: A new role for bacterial proteases

This paper shows that Porphyromonas gingivalis proteases reduce viral load and modulate host interferon responses during RSV infection.

Upper Airway Gene Expression in Hospitalized Children with Rhinovirus-induced Respiratory Illnesses

This study compares nasal transcriptomic data from hospitalized children with RV, RSV, and control infections, identifying virus-specific gene expression patterns and immune responses.

Targeting Wnt Signaling and DNAJB6/MRJ-L as a Dual Anti-RSV Strategy: Insights into a Positive Regulatory Loop

This study identifies a positive regulatory loop between Wnt signaling and MRJ-L that promotes RSV replication and suggests dual targeting of this axis as a potential antiviral strategy.

Defining the host dependencies and the transcriptional landscape of RSV infection and bystander activation

This study uses CRISPR screening and single-cell RNA sequencing to analyze host factors and transcriptional changes in RSV-infected and bystander cells, revealing distinct gene expression patterns and host dependencies.

Mechanisms of G-gene heterogeneities and a new method of genotyping of human metapneumovirus

The paper analyzes G-gene heterogeneities in human metapneumovirus (HMPV) and proposes a new genotyping method based on protein length and sequence differences.

Tiled PCR amplification-based Whole Genome Sequencing and Phylogenetic Classification Accelerate the Implementation of Respiratory Syncytial Virus Genomic surveillance in Canada as a Pilot Study

The paper develops tiled PCR assays for RSV whole genome sequencing, enabling high-throughput surveillance and improved phylogenetic analysis with more discriminatory mutations identified.

Temporal High-Resolution Atlas of Human Blood Leukocyte Composition in Response to Respiratory Virus Inoculation

The paper constructs a temporal atlas of human blood leukocyte changes after respiratory virus infection, showing shared immune responses and virus-specific kinetics.

Complete Genomic Characterization of Global Pathogens, Respiratory Syncytial Virus (RSV), and Human Norovirus (HuNoV) Using Probe-based Capture Enrichment.

This paper presents a probe-based capture enrichment method to obtain full-length genomes of RSV and HuNoV from clinical samples, achieving high completeness and improving variant tracking.

SARS-CoV-2 Mediated Inhibition Of Respiratory Syncytial Virus

This study shows SARS-CoV-2 inhibits RSV replication by disrupting the M2-2 protein through interference with ribosomal termination-reinitiation, suggesting potential therapeutic strategies.

ANALYSIS OF RESPIRATORY SYNCYTIAL VIRUS REVEALS CONSERVED RNA SECONDARY STRUCTURAL MOTIFS AND IMPACT VIRAL LIFECYCLE

The paper analyzes RSV RNA structures and finds conserved motifs that may impact viral replication, using bioinformatics and experimental methods.

RESPIRATORY SYNCYTIAL VIRUS NON-STRUCTURAL PROTEIN EXPRESSION ARE LIMITED IN NEUTROPHILS

The paper shows that RSV Ns2 expression is reduced in neutrophils, suggesting RSV infection is functionally non-permissive in vivo.

Exploring respiratory viral pathogens and bacteriome from symptomatic SARS-CoV-2-negative and positive individuals

This study identifies co-infections with other respiratory viruses and bacteria in SARS-CoV-2-positive and negative patients, finding higher viral infections in negatives and specific bacterial phyla in both groups.

The nasopharyngeal virome in adults with acute respiratory infection

This study uses metagenomic sequencing to analyze the nasopharyngeal virome in adults with acute respiratory infection, finding high viral diversity and discrepancies between PCR and sequencing results.

Examining intra-host genetic variation of RSV by short read high-throughput sequencing

The paper analyzes intra-host RSV genetic variation using short-read sequencing, finding low variation but differences between genomic and transcriptomic data.

Understanding the mechanism of the SARS CoV-2 coinfection with other respiratory viruses

The paper evaluates the prevalence of viral coinfections in COVID-19 patients across different geographies and time periods.

Clustered Cases of Human Adenovirus types 4, 7 and 14 Infections during the 2018 - 2019 Season revealed by US Department of Defense Respiratory Pathogen Surveillance and Whole Genome Sequencing

The paper uses genomic surveillance to identify clustered HAdV infections during the 2018-2019 season and detects genetic mutations in circulating strains.

Molecular epidemiology of human respiratory syncytial virus with severe acute respiratory infection in Huzhou from 2016 to 2019

The paper analyzes HRSV circulation in Huzhou, China, from 2016 to 2019, finding co-circulation of subgroups A and B with highest infection rates in infants.

Genomics of Human Respiratory Syncytial Virus Vaccine Attenuation

The paper identifies mutations frequent in HRSV vaccine candidates and rare in wild-type genomes that may contribute to vaccine attenuation.

Respiratory Syncytial Virus Infections Induce Hypermetabolism in Pediatric Upper Airways

This study shows RSV infection increases metabolism in pediatric upper airway cells and fluids, suggesting hypermetabolism as a potential therapeutic target.

Respiratory Syncytial Virus in Infants and Children with Prader-Willi syndrome.

This study examines RSV infection rates, hospitalization, and outcomes in children with Prader-Willi syndrome, finding high infection rates and severe complications, with recommendations for improved vaccination and healthcare access.

Insufficiency in airway interferon activation defines clinical severity to infant RSV infection

The paper identifies a lack of airway interferon activation as a marker of severe infant RSV infection and shows that blocking IFN signaling increases viral infection in vitro.

FilmArray Respiratory Panel Integrated in a field Point Of Care dispositive for the diagnosis of respiratory tract infections in rural areas in Senegal

This study evaluates the use of the FilmArray respiratory panel in a field Point of Care (POC) setting in rural Senegal to diagnose respiratory tract infections, finding higher pathogen prevalence in children under 5 and seasonal variations.