Invertebrate Immune Response Mechanisms

Heterogeneity in the response of different subtypes of Drosophila melanogaster enteroendocrine cells to viral infections

The paper uses scRNA-seq to compare how two viruses affect enteroendocrine cells in Drosophila, showing subtype-specific replication strategies and gene expression changes.

Insulin-like signalling influences the coordination of Drosophila larval hemocyte number with body size

This study shows that insulin-like signaling coordinates Drosophila larval hemocyte number with body size, with reduced growth rate and impaired signaling leading to fewer hemocytes.

Effect of prolonged captivity on the hemolymph profile of Tachypleus gigas

The paper examines how captivity affects amebocyte cell quality in Tachypleus gigas and finds captivity reduces cell viability, while anticoagulant formulations significantly impact cell density, viability, and morphology.

Regulation of blood cell transdifferentiation by oxygen sensing neurons in Drosophila

The paper identifies a mechanism by which oxygen-sensing neurons in Drosophila larvae promote blood cell transdifferentiation through the activity of the guanylyl cyclase Gyc88E.

Identification of functionally-distinct macrophage subpopulations regulated by efferocytosis in Drosophila

The paper identifies functionally distinct plasmatocyte subpopulations in Drosophila regulated by efferocytosis and shows how their behavior and abundance can be modulated.

Context-specific functions of Notch in Drosophila blood cell progenitors

The paper identifies context-specific roles of Notch signaling in different progenitor populations during Drosophila larval hematopoiesis.

Temporal specificity and heterogeneity of the fly immune cells' transcriptional landscape

The paper uses bulk and single-cell RNA sequencing to study Drosophila hemocyte heterogeneity across developmental stages and immune challenges, identifying novel cell types and functional states.

A comparative analysis of Caenorhabditis and Drosophila transcriptional changes in response to pathogen infection

The paper compares transcriptional responses to bacterial pathogens in Drosophila and Caenorhabditis, finding conserved and divergent gene expression patterns.

Hemocyte-targeted gene expression in the female malaria mosquito using the hemolectin promoter from Drosophila

The paper develops a hemocyte-specific promoter tool in Anopheles gambiae to study immune functions and pathogen interactions in malaria mosquitoes.

The APL1 immune factor is encoded by a single ancestral gene in most Anopheles species and expanded to three paralogs with distinct function in the Anopheles gambiae complex

This study identifies APL1 as a single ancestral gene in most Anopheles species and shows its expansion to three paralogs in the Gambiae complex, with distinct functional roles in immunity and malaria transmission.

C. elegans heritably adapts to P. vranovensis infection via a mechanism that requires the cysteine synthases cysl-1 and cysl-2

The paper shows that parental exposure to P. vranovensis increases offspring survival through upregulation of CYSL-1, CYSL-2, and RHY-1.

Spodoptera frugiperda transcriptional response to infestation by Steinernema carpocapsae

The paper examines the transcriptional responses of Spodoptera frugiperda tissues to Steinernema carpocapsae infestation, identifying gene expression changes and potential immune effectors acquired via horizontal gene transfer.

Anti-tumor effects of antimicrobial peptides, targets of the innate immune system, against hematopoietic tumors in Drosophila mxc mutants

The paper shows that antimicrobial peptides (AMPs) suppress tumor growth in Drosophila mxc mutants by inducing apoptosis in tumor cells.

The genome of Drosophila innubila reveals lineage-specific patterns of selection in immune genes

The paper sequences the genome of Drosophila innubila and finds that antiviral RNAi genes evolve slowly, contrasting with Drosophila melanogaster, suggesting different evolutionary pressures for DNA and RNA virus resistance.

Antagonistic paralogs control a switch between growth and pathogen resistance in C. elegans

This study identifies two C. elegans-specific genes, pals-22 and pals-25, which function as antagonistic regulators controlling the switch between growth and pathogen resistance.

The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner

This study shows that the Toll pathway inhibits tissue growth and enhances cell fitness in an infection-dependent manner by regulating apoptosis and proliferation.

Energetic stress and infection generate immunity-fecundity tradeoffs in Drosophila

The paper shows that genetic variation in energy metabolism in Drosophila leads to immunity-fecundity tradeoffs, particularly in females under resource limitation.

Modulatory upregulation of an insulin peptide gene by different pathogens in C. elegans

This study shows that ins-11, an insulin peptide gene in C. elegans, is upregulated by different pathogens in specific tissues and influences immune responses and longevity.