Invertebrate Immune Response Mechanisms

Within-species control reveals novel immune response genes in Caenorhabditis elegans

The paper identifies three novel immune response genes in C. elegans by using a more suitable control strain, P. aeruginosa z11, instead of E. coli OP50.

Single-cell perspectives on the function and development of deep-sea mussel bacteriocytes

The paper withdraws due to insufficient data and experimental evidence, acknowledging limitations in single-cell transcriptomics and in situ hybridization.

Meta-analysis of immune induced gene expression changes in diverse Drosophila melanogaster innate immune responses

The paper identifies conserved gene expression changes and transcription factor binding sites in Drosophila melanogaster across diverse immune responses to pathogens.

Wild-type Caenorhabditis elegans Isolates Exhibit Distinct Gene Expression Profiles in Response to Microbial Infection

The paper compares gene expression responses to microbial infection in two C. elegans isolates, finding isolate- and pathogen-specific differences in gene expression.

Injury-induced inflammatory signaling and hematopoiesis in Drosophila

The paper investigates injury-induced inflammatory signaling and hematopoiesis in Drosophila larvae, identifying Toll and JNK signaling activation and the role of Upd3 in lamellocyte differentiation.

SUMOylation of Jun fine-tunes the Drosophila gut immune response

This study shows that SUMOylation of Jra in Drosophila modulates the gut immune response to Pseudomonas entomophila by regulating gene expression and immune signaling.

Balancing selection of the Intracellular Pathogen Response in natural Caenorhabditis elegans populations

The paper examines genetic variation in the Intracellular Pathogen Response (IPR) in C. elegans, finding balancing selection in key regulators and showing haplotype-specific antiviral defense.

Drosophila macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2

This study identifies Pvf2 as a key regulator of macrophage self-renewal in Drosophila by showing its transient expression in blood cells and its role in driving population expansion.

Drosophila hemocytes recognize lymph gland tumors of mxc mutants and activate the Toll pathway in reactive oxygen species-dependent manner

The paper shows Drosophila hemocytes recognize mxc mutant lymph gland tumors, activate the Toll pathway via reactive oxygen species, and induce antimicrobial peptides in the fat body.

Co-option of immune effectors by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster

The paper shows ecdysone regulates antimicrobial peptide expression during Drosophila metamorphosis, linking hormonal signaling to immune function and bacterial control.

Pvr and downstream signaling factors are required for spreading of Drosophila hemocytes at larval wound sites

This study identifies Pvr and Pvf1 as essential for hemocyte spreading at Drosophila larval wound sites and identifies downstream factors involved in wound responses.

Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways

This study shows parasitic nematode fatty acid- and retinol-binding proteins (FARs) suppress host immunity by modulating lipid signaling pathways and reducing antimicrobial peptide production in flies.

Zika virus infection drives epigenetic modulation of immunity by the histone acetyltransferase CBP of Aedes aegypti

This study shows Zika virus infection increases Aedes aegypti histone acetyltransferase CBP activity, enhancing immune gene expression and reducing viral titers.

Haemocytes are critical for Drosophila melanogaster post-embryonic development, independent of control of the microbiota

This study shows that haemocyte ablation in Drosophila melanogaster causes pupal lethality even under axenic conditions, indicating a critical role in post-embryonic development beyond microbiota control.

Characterization of the Drosophila adult hematopoietic system reveals a rare cell population with differentiation and proliferation potential.

The paper characterizes the Drosophila adult hematopoietic system, identifying a rare cell population with differentiation and proliferation potential in response to infection.

The genetic basis of Drosophila melanogaster defense against Beauveria bassiana explored through evolve and resequence and quantitative trait locus mapping

This study investigates the genetic basis of Drosophila melanogaster's defense against Beauveria bassiana using QTL mapping and evolve and resequence approaches, revealing genetic variation and trade-offs in immune defense.

Relish plays a dynamic role in the niche to modulate Drosophila bloodprogenitor homeostasis in development and infection.

This study shows Relish in Drosophila hematopoietic niche modulates blood progenitor homeostasis during development and infection by regulating cytoskeletal architecture and differentiation.

Host-pathogen Immune Feedbacks Can Explain Widely Divergent Outcomes from Similar Infections

The paper uses computational models to show that host-pathogen feedbacks can lead to divergent infection outcomes, even with similar initial conditions.

Immune priming can prevent WNV establishment in Culex quinquefasciatus mosquitoes: evidence for immune priming based reversal of WNV-mediated immune suppression.

The paper shows that immune priming with inactivated WNV reduces transmissible WNV infection in mosquitoes by reversing immune suppression through enhanced gene expression.

Dense time-course gene expression profiling of the Drosophila melanogaster innate immune response

The paper performs high-resolution RNA-seq time course analysis of Drosophila immune response to Imd stimulation, identifying gene expression dynamics and trade-offs with metabolic processes.

Differential activation of JAK-STAT signaling in blood cell progenitors reveals functional compartmentalization of the Drosophila lymph gland.

The paper identifies functional differences in JAK-STAT signaling between anterior and posterior progenitors in the Drosophila lymph gland, showing how compartmentalization affects immune response.

Epithelial infection with Candida albicans elicits a multi-system response in planarians

This study identifies two C. albicans proteins essential for epithelial infection of planarians and describes a multi-system host response involving stem cells and distinct tissues.

Novel Immune Modulators Enhance Caenorhabditis elegans Resistance to Multiple Pathogens

This study identifies five compounds that enhance Caenorhabditis elegans resistance to multiple pathogens by activating host defense pathways.

The vascular niche controls Drosophila hematopoiesis via Fibroblast Growth Factor signaling

This study identifies the vascular niche as a second regulator of Drosophila hematopoiesis, showing that FGF signaling from vascular cells maintains hematopoietic progenitors.

Metabolic control of immune-competency by odors in Drosophila

This study shows that odor exposure in Drosophila larvae increases systemic GABA and blood-progenitor Sima levels, enhancing lamellocyte induction and immune response efficiency.

Widely used mutants of eiger, encoding the Drosophila Tumor Necrosis factor, carry additional mutations in the NimrodC1 phagocytosis receptor

The paper identifies additional mutations in the NimrodC1 phagocytosis receptor in widely used egr3 mutant Drosophila strains, which may affect phagocytic function.

Dscam1 promotes blood cell survival in Drosophila melanogaster through a dual role in blood cells and neurons

This study shows Dscam1 supports blood cell survival in Drosophila by acting in both sensory neurons and hemocytes, with effects mediated through the adapter protein Dock.

Transcriptome profiling of a multiuse model species Lymnaea stagnalis (Gastropoda) for ecoimmunological research

The paper profiles the transcriptome of Lymnaea stagnalis to identify immune-related genes and their expression under various immune and environmental conditions.

Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila

The paper uses single-cell RNA sequencing to analyze myeloid blood cell lineages in Drosophila, identifying novel cell types and lineage dynamics during immune responses.

Developmental retrotransposon activation primes host immunity for future viral-clearance

The paper shows that Gypsy retrotransposon activation during Drosophila metamorphosis primes innate immunity, enhancing viral clearance in adult flies.