Nuclear Structure and Function

The paper compares single-molecule trajectories with correlation-based measurements to show that nuclear pore transport occurs rapidly through FG-nucleoporin dynamics.

This study shows that prelamin A does not cause vascular smooth muscle loss or atherosclerosis, unlike progerin in HGPS.

The paper shows that wound healing in Drosophila involves reversible chromatin-lamina dewetting triggered by mechanical changes, leading to cellular contraction and tissue repair.

This study identifies a stress response pathway linking nucleolar disruption to cellular quiescence and secretion, revealing its role in cancer progression.

This study identifies and characterizes novel nuclear pore complex components in Toxoplasma gondii, revealing divergence in mRNA export machinery compared to other eukaryotes.

This study shows that chromatin compaction influences T cell spreading and immune synapse formation by modulating actin cytoskeletal organization.

This study uses live-cell imaging to track nuclear and nucleolar changes during γ-irradiation-induced mitotic catastrophe and apoptosis in HeLa cells, revealing distinct stages of nuclear deformation and nucleolar remodeling.

This paper develops a biophysical model to explain how HIV-1 capsids translocate through the nuclear pore complex, showing that competitive binding and geometric changes enable fast and complete nuclear import.

This study shows that nuclear mechanostability arises from satellite DNA condensation into chromocenters, which help dissipate mechanical stress and protect genome integrity.

This study shows that rRNA intermediates influence nucleolar structure in C. elegans by altering protein distribution and causing architectural changes.

The paper determines the sub-nanometer structure of the SUN5-Nesprin3 LINC complex in human sperm cells, revealing its role in nuclear envelope remodelling and male infertility.

This paper introduces a nanobody-based method to detect newly forming nuclear pore complexes in yeast, revealing novel insights into their assembly and localization.

This study identifies Sp100-HMG as a master liquid nucleator that drives 'inside-out' PML-NB assembly, modulating transcription and cell-cycle dynamics through hierarchical condensation.

This study identifies a Sir2-dependent Csa1-Lro1 pathway at the inner nuclear membrane that regulates lipid droplet formation and nuclear shape in budding yeast.

This study shows that asp and Sas4 genes in Drosophila affect nuclear structure, chromatin organization, and genome stability, contributing to microcephaly pathogenesis.

This study identifies the A-type lamin rod domain as the key determinant of nuclear deformability, revealing its unique role in resisting large mechanical forces on the nucleus.

The paper identifies a plant-specific PY-NLS pathway mediated by TRN1, revealing structural features distinguishing plant PY-NLSs from animal and fungal models.

The paper identifies disordered regions in the coiled-coil domain of TPR, showing they form condensates and create a permeability barrier at the nuclear pore basket.

This study shows that the lamin A K97E mutation disrupts PHB2 interaction, causing mitochondrial dysfunction, ROS elevation, and metabolic imbalance, contributing to dilated cardiomyopathy.

The paper uses a yeast model to identify the nuclear import mechanism of SMAD3, showing that the MH1 domain functions as an importin binding surface.

This paper develops a human iPSC-based model of L-CMD to test gene editing strategies for muscle laminopathies, showing partial reversal of disease phenotypes with precise mutation correction.

The paper shows that Nopp140 concentrates intrinsically disordered regions to form the DFC, a phase-separated condensate that enables efficient rRNA modification.

The paper shows the nucleus actively directs mechanical properties of actin cytoskeleton via FHOD-associated LINC complexes, and disruption causes cardiac hypertrophy.

This study identifies a dynamic nuclear-plasma membrane contact mediated by the LINC complex that maintains epithelial architecture through Src signaling.

The paper proposes a wetting-based mechanism for chromatin condensate localization at the nuclear lamina through surface-enriched proteins, showing nonmonotonic density profiles and regulatory effects of non-binding proteins.

This study shows that microtubules drive rapid nuclear movement and extreme deformations in male nuclei of Podospora anserina during sexual reproduction.

The paper investigates how neural crest cells adapt to physical confinement during migration in zebrafish embryos, finding that nuclear deformation occurs without DNA damage.

This study uses elastic network models and molecular dynamics simulations to analyze the conformational dynamics of the nuclear pore complex, revealing mechanisms of its two-state transition and FG repeat behavior.

The paper shows a protein-DNA co-condensate forms a surface hydrogel that mechanically reinforces the nucleus and protects DNA from damage during mechanical stress.

The paper constructs a Rainbow Nucleus cell line to study interactions between nuclear membrane-less organelles, finding structured, transcription-dependent contact networks.