Immune responses and vaccinations

Myeloid cell reprogramming drives enhanced defense against Streptococcus pneumoniae lung infection following exposure to commensal Prevotella

The paper shows that exposure to Prevotella melaninogenica reprograms myeloid cells to enhance defense against Streptococcus pneumoniae lung infection.

Perinatal Nicotine Exposure Disrupts Hematopoietic Stem Cell Development and Elevates Influenza Susceptibility in Adulthood

Differential effects of BCG-Russia and BCG-TICE on trained immunity: potential implications for bladder cancer immunotherapy

This study compares the effects of BCG-Russia and BCG-TICE on trained immunity in mice, finding BCG-TICE induces stronger innate immune memory and inflammation-related gene expression.

The C3-C3aR axis modulates trained immunity in alveolar macrophages

This study shows that C3 modulates trained immunity in alveolar macrophages via C3aR signaling, enhancing glycolytic activity and cytokine output.

Comparative analysis of BCG vaccination routes in mice reveals preferential reprogramming of pulmonary macrophages upon mucosal administration

This study compares BCG vaccination routes in mice, showing that mucosal delivery reprograms interstitial macrophages and enhances protection against TB.

Environmental drivers of low vaccine responsiveness in a lab-to-wild rodent model

This study investigates how environmental factors affect vaccine responsiveness in wild and lab wood mice, finding diet and helminth infection significantly impact antibody production.

β-Glucan Modulates Monocyte Plasticity and Differentiation Capacity to Mitigate DSS-Induced Colitis

This study shows that β-glucan reprograms monocytes to reduce DSS-induced colitis severity by enhancing reparative macrophage generation and epithelial regeneration.

Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk

This study shows that repeated cytokine exposure in endothelial cells induces memory-like responses, linking chronic inflammation to vascular disease risk through persistent transcriptional and epigenetic changes.

The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity

The paper identifies an epigenetic mechanism in bronchial epithelial cells that enables trained immunity through chromatin remodeling and gene expression changes following flagellin exposure.

Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism

This study shows Aurora kinase A promotes trained immunity by regulating S-adenosylmethionine metabolism through the mTOR-FOXO3-GNMT axis.

Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

This study shows that malnutrition impairs immune function and myelopoiesis in mice, which partially recovers with refeeding but does not fully restore infection resistance.

Trained Immunity Causes Myeloid Cell Hypercoagulability

This study identifies enhanced myeloid cell prothrombotic activity as a novel consequence of trained immunity, mediated by epigenetic changes and acid sphingomyelinase.

Long-term immune changes after COVID-19 and the effect of BCG vaccination and latent infections on disease severity

This study examines long-term immune changes post-COVID-19 and the impact of BCG vaccination and latent infections on disease severity.

Early and Delayed STAT1-Dependent Responses Drive Local Trained Immunity of Macrophages in the Spleen

This study identifies early and delayed STAT1-dependent responses in splenic macrophages that drive trained immunity, enhancing protection against Salmonella Typhimurium infection.

BCG immunization-induced KLRG1+ NK cells show memory-like responses to mycobacterial and HIV antigens

This study shows BCG vaccination induces KLRG1+ NK cells that produce IFN-gamma in response to both MTB and HIV antigens, suggesting memory-like immunity against these pathogens.

The Immune Signatures Data Resource: A compendium of systems vaccinology datasets

The paper introduces the Immune Signatures Data Resource, a compendium of standardized systems vaccinology datasets for comparative vaccine response analysis.

Epidemiological transcriptomic data supports BCG protection in viral diseases including COVID-19

The paper analyzes transcriptomic data to show BCG vaccination induces long-lasting transcriptomic changes that both mimic and oppose viral infections, offering insights into its potential protection against COVID-19.