Lipid metabolism and disorders

The Hunt for Cholesteryl Ester Hydrolases: Identification of Lipoprotein Lipase as a Cholesterylesterase

This study identifies lipoprotein lipase (LPL) as a neutral cholesteryl ester hydrolase in mammals through biochemical and pharmacological analyses.

A Mathematical Model of Dietary Lipid Absorption and Postprandial Chylomicron Dynamics

This paper develops a mathematical model of chylomicron dynamics incorporating the second meal effect, showing it can predict postprandial lipid responses across different BMI values.

Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variant

This study investigates how the GKRP P446L variant affects hepatic lipid and cholesterol metabolism by reducing GCK activity and increasing cholesterol synthesis.

GPR182 is a lipoprotein receptor for dietary fat absorption

This study identifies GPR182 as a lipoprotein receptor that mediates dietary fat absorption and shows its role in obesity resistance.

Directly Measuring Atherogenic Lipoprotein Kinetics in Zebrafish with the Photoconvertible LipoTimer Reporter

The paper develops a zebrafish reporter to measure atherogenic lipoprotein kinetics and finds that lipolysis is suppressed by high-fat meals.

Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice

This study shows that reducing CPT1a in the liver lowers apoB-containing lipoproteins and cholesterol in mice, with increased clearance of these lipoproteins linked to enhanced PPAR signaling.

ANGPTL3 regulates the peroxisomal translocation of SmarcAL1 in response to cell growth states

This study shows that ANGPTL3 regulates SmarcAL1 translocation to peroxisomes, affecting lipid metabolism and TG storage in response to cell growth states.

Effects of Age and Diet on Triglyceride Metabolism in Mice

This study examines how age and diet affect triglyceride metabolism in mice, finding that triglyceride levels do not increase with age and that an omega-3-rich diet improves insulin sensitivity and cardiac triglyceride uptake.

Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry

The paper identifies genetic risk factors for hypertriglyceridemia in African ancestry populations using whole genome sequencing and electronic health records.

Novel zebrafish mutants reveal new roles for Apolipoprotein B during embryonic development and pathological conditions

This study creates zebrafish mutants to study Apolipoprotein B's role in development and disease, finding defects in lipid metabolism and vascular development.

ANGPTL8 protein-truncating variant and the risk of coronary disease, type 2 diabetes and adverse effects

The paper identifies protein-truncating variants in ANGPTL8, ANGPTL4, and LIPG associated with lipid levels and cardiometabolic disease risk, and reports their associations with type 2 diabetes, coronary artery disease, and other adverse effects.

Targeted sequencing of candidate genes of dyslipidemia in Punjabi Sikhs: Population-specific rare variants in GCKR promote ectopic fat deposition

The paper identifies population-specific rare variants in GCKR associated with hypertriglyceridemia and ectopic fat deposition using targeted sequencing and zebrafish models.

Metabolomic signature of angiopoietin-like protein 3 deficiency in fasting and postprandial state

This study examines the metabolic effects of ANGPTL3 deficiency in fasting and postprandial states, finding reduced lipoprotein cholesterol and increased ketone bodies in carriers.

EDEM3 modulates plasma triglyceride level through its regulation of LRP1 expression

The paper identifies a missense variant in EDEM3 associated with lower blood triglyceride levels and shows EDEM3 deficiency increases LRP1 expression, reducing plasma TG through enhanced lipoprotein uptake.